Article
Immunology
Eleni Fella, Revekka Papacharalambous, Demos Kynigopoulos, Maria Ioannou, Rita Derua, Christiana Christodoulou, Myrto Stylianou, Christos Karaiskos, Alexia Kagiava, Gerasimou Petroula, Chryso Pierides, Maria Kyriakou, Laura Koumas, Paul Costeas, Elena Panayiotou
Summary: Research has found that the modified C5a receptor agonist (EP67) can significantly reduce beta-amyloid deposition and gliosis, and improve cognitive impairment in advanced stages of Alzheimer's disease. Proteomic analysis suggests that these effects may be triggered by the upregulation of beta-adrenergic and GABAergic signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elena Tamagno, Michela Guglielmotto, Valeria Vasciaveo, Massimo Tabaton
Summary: The pathogenesis of Alzheimer's disease involves the accumulation of beta amyloid and vulnerability of the brain to oxidative stress, which are linked to each other. It is difficult to determine which comes first, Aβ or oxidative stress. Evidence suggests that oxidative stress occurs early in the development of Alzheimer's disease and plays a crucial role in the manifestation of clinical and pathological symptoms.
Review
Chemistry, Medicinal
Weimin Qiu, Hui Liu, Yijun Liu, Xin Lu, Lei Wang, Yanyu Hu, Feng Feng, Qi Li, Haopeng Sun
Summary: Alzheimer's disease (AD) is a difficult to treat progressive neurodegenerative disease characterized by the accumulation of amyloid beta (A beta) plaques in the brain. A beta interacts with various receptors on the plasma membrane and mediates signaling pathways that contribute to the development of AD. Despite ongoing research, there are currently no effective medications for AD. This review discusses the importance of A beta in the pathogenesis of AD, recent progress in targeting A beta-related receptors and compounds, and the challenges and opportunities in developing effective therapies for AD.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Zhong-Yuan Yu, Xu Yi, Ye-Ran Wang, Gui-Hua Zeng, Cheng-Rong Tan, Yuan Cheng, Pu-Yang Sun, Zhi-Hao Liu, Yan-Jiang Wang, Yu-Hui Liu
Summary: This study investigates the role of alpha 1 adrenergic receptors (alpha 1-ARs) in the pathogenesis of Alzheimer's disease (AD) and suggests that targeting the alpha 1-ARs signaling pathway could be a promising therapeutic strategy for AD. Knockdown of alpha 1-ARs improves behavioral performance and reduces brain amyloid burden in AD mice, while inhibition of alpha 1-ARs with terazosin reduces amyloid beta deposition, attenuates downstream pathologies, and rescues behavioral deficits in AD mice.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Cell Biology
Song Li, Che Wang, Zhen Wang, Jun Tan
Summary: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly population, characterized by beta-amyloid plaques and neurofibrillary tangles. Evidence suggests that cerebrovascular dysfunctions may play an important role in the development of AD, leading to potential new approaches for diagnosis, prevention, and treatment of the disease.
Article
Neurosciences
Danique R. Hutten, Jens H. J. Bos, Stijn de Vos, Eelko Hak
Summary: This retrospective inception cohort study found that exposure to non-selective beta AR antagonists may increase the risk of developing Alzheimer's disease in older adults, while exposure to selective beta 2AR agonists may decrease the risk.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Gillian Bonvicini, Stina Syvanen, Ken G. G. Andersson, Merja Haaparanta-Solin, Francisco Lopez-Picon, Dag Sehlin
Summary: This study investigates the efficacy of using transferrin receptor (TfR) as a targeting strategy to transport amyloid-beta (Aβ) immunoPET ligands across the blood-brain barrier (BBB). The results indicate that the affinity to TfR affects the efficiency of crossing the BBB, and this method shows potential for imaging Aβ pathology in rats.
TRANSLATIONAL NEURODEGENERATION
(2022)
Review
Biochemistry & Molecular Biology
Anne-Cathrine S. Vogt, Gary T. Jennings, Mona O. Mohsen, Monique Vogel, Martin F. Bachmann
Summary: Alzheimer's disease is the most common form of dementia and is responsible for 60-70% of cases. The number of people with dementia is expected to triple by 2050 due to an aging population. Currently, there are only symptomatic treatments available, making it crucial to develop novel therapeutic strategies to prevent or delay the onset of Alzheimer's disease. This mini-review focuses on the understanding of Alzheimer's disease pathobiology and discusses current immunomodulating therapies targeting amyloid-beta protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ratnakar Jadhav, Yogesh A. Kulkarni
Summary: Alzheimer's disease is a neurodegenerative condition characterized by progressive loss of memory and cognitive dysfunction, particularly in older individuals. The prevalence of the disease has increased due to the global aging population. Current treatments for Alzheimer's disease have limited efficacy and adverse effects. Recent research suggests that natural products, such as baicalein, could be potential treatment options for Alzheimer's disease. Baicalein, a flavonoid from the flavone subclass, has shown neuroprotective properties through its antioxidant, anti-inflammatory, AChE enzyme inhibitory, and anti-amyloid protein aggregation activities.
Review
Biochemistry & Molecular Biology
Andrila E. Collins, Tarek M. Saleh, Bettina E. Kalisch
Summary: The prevalence of Alzheimer's disease is estimated to double by 2040. Current treatments do not address the underlying causes of the disease, but research suggests that antioxidants may help mitigate oxidative stress. Recent studies have focused on natural antioxidants as potential preventatives and treatments for neurodegenerative conditions associated with oxidative stress.
Article
Immunology
Liu Yang, Huimin Zhou, Lei Huang, Yong Su, Liangliang Kong, Pengmin Ji, Ran Sun, Chao Wang, Weiping Li, Weizu Li
Summary: Chronic glucocorticoid exposure can accelerate neuronal damage and beta-amyloid production by activating oxidative stress and NLRP1 inflammasome, leading to the deterioration of Alzheimer's disease. Inhibition of NLRP1 inflammasome may be an important strategy in improving chronic glucocorticoid-induced neuronal injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Rana Mabrouk, Maria Gotkiewicz, Tuomas Rauramaa, Heikki Tanila
Summary: DAPI is commonly used as a nuclear stain, but it can also specifically bind to the beta-sheet core of amyloid-beta plaques. Although DAPI staining may give a misleading impression, it is still a convenient and cost-effective method for staining both cell nuclei and amyloid plaques simultaneously.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Ruifeng Zhang, Miao Zeng, Xiaolu Zhang, Yujia Zheng, Nuan Lv, Luming Wang, Jiali Gan, Yawen Li, Xijuan Jiang, Lin Yang
Summary: Saponins, specifically ginsenoside Rg1 and pseudoginsenoside-F11, show the most promise in treating Alzheimer's disease by reducing amyloid beta peptide deposition, inhibiting tau phosphorylation, modulating oxidative stress, reducing inflammation, and antiapoptosis. This review provides a comprehensive summary and classification of common saponins studied for their therapeutic potential in Alzheimer's disease, showcasing their underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Gong Peng, Ming Li, Zhaoli Meng
Summary: Alzheimer's disease is a devastating disease with no disease-modified treatment discovered yet. Recent studies have shown that polysaccharides potentially have benefits in alleviating the pathological damage and improving cognitive symptoms of Alzheimer's disease, but further research is needed.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Xin Chen, Santosh Pandit, Lei Shi, Vaishnavi Ravikumar, Julie Bonne Kohler, Ema Svetlicic, Zhejian Cao, Abhroop Garg, Dina Petranovic, Ivan Mijakovic
Summary: Alzheimer's disease is a common neurodegenerative disease characterized by the aggregation of misfolded amyloid-beta peptides in the brain. Graphene oxide nanoflakes have been found to effectively inhibit A beta aggregation in vitro. In this study using yeast as a model, it is shown that graphene oxide can penetrate yeast cells and reduce A beta 42 toxicity. The findings provide insights for designing graphene oxide-based therapies for attenuating cytotoxicity of A beta 42 and other misfolded proteins involved in neurodegenerative pathology.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ke-Liang Chen, He Wang, Gui-Xian Zhao, Lei Wei, Yu-Yuan Huang, Shi-Dong Chen, Jian Sun, Qiang Dong, Mei Cui, Jin-Tai Yu
Summary: A novel homozygous RNF216 p.E650X mutation causing Gordon Holmes syndrome was identified in this study, expanding the genetic knowledge of GHS and extending the ethnic distribution of RNF216 mutations.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jia-Hui Hou, Ya-Nan Ou, Wei Xu, Peng-Fei Zhang, Lan Tan, Jin-Tai Yu
Summary: This study found that peripheral immune cells and the ratio of these cells were associated with cognitive function, neuroimaging, and AD pathology. These associations may be mediated by beta-amyloid and tau pathology.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Bang-Sheng Wu, Shu-Fen Chen, Shu-Yi Huang, Ya-Nan Ou, Yue-Ting Deng, Shi-Dong Chen, Qiang Dong, Jin-Tai Yu
Summary: By integrating multidimensional data, we identified causal genes in the pathogenesis of small-vessel stroke (SVS), offering hints for future biological and therapeutic studies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Shu-Yu Liang, Zuo-Teng Wang, Lan Tan, Jin-Tai Yu
Summary: This article introduces the function and dysfunction of microtubule-associated protein tau in the central nervous system and discusses its role in neurodegenerative diseases, tau phosphorylation-related enzymes and proteins, and its relationship with cell dysfunction. The study of tau neurotoxicity provides new directions for the treatment of tauopathies.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Yi Zhang, Kai-Min Wu, Liu Yang, Qiang Dong, Jin-Tai Yu
Summary: In this article, emerging knowledge on tauopathies from clinical, pathological, genetic, and experimental studies is synthesized to accelerate the development of therapeutics for these diseases. The focus is on depicting pathological characteristics, identifying biomarkers, elucidating the underlying pathogenesis for early diagnosis, and the development of disease-modifying therapies.
MOLECULAR NEURODEGENERATION
(2022)
Article
Environmental Sciences
He-Ying Hu, Ya-Hui Ma, Yue-Ting Deng, Ya-Nan Ou, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu
Summary: This study found an association between residential greenness and dementia incidence, indicating that increasing greenspace can reduce the risk of dementia. The protective effect of greenness may be mediated through the reduction of particulate air pollution.
ENVIRONMENTAL RESEARCH
(2023)
Review
Clinical Neurology
Na Zhang, Ke-Liang Chen, Yu-Yuan Huang, Shu-Fen Chen, Qiang Dong, Lan Tan, Jin-Tai Yu
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Neurosciences
Zuo-Teng Wang, Yan Fu, Shi-Dong Chen, Yu-Yuan Huang, Ya-Hui Ma, Yan-Jiang Wang, Lan Tan, Jin-Tai Yu
Summary: This study is the first to identify significant associations between TREM1 rs2062323 and AD risk. The rs2062323T may be involved in AD by regulating the expression of TREM1, TREML1, TREM2, and sTREM2. The TREM family is expected to be a potential therapeutic target for AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Yan Fu, Yan Sun, Zhi-Bo Wang, Dan-Dan Zhang, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study used the American Heart Association's Life's Simple 7 (LS7) metric to define cardiovascular and brain health and found that ideal LS7 cardiovascular health factors are associated with both macrostructural and microstructural markers of brain health. The results suggest that better LS7 profiles are linked to better brain health.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yan Sun, Yu Guo, Hong-Qi Li, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: White matter hyperintensities (WMH) are strongly associated with stroke, dementia, and early mortality. This study investigated the relationship between WMH and circulating metabolites in a large sample of individuals from the UK Biobank. The results showed that several metabolites, including high-density lipoprotein (HDL), fatty acids, and glycoprotein acetyls, were associated with WMH. Age and sex also had a significant influence on these associations. The findings suggest that specific metabolomic features accompany WMH and may provide insights into the implications of WMH in different populations.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Yu He, Shu-Yi Huang, Hui-Fu Wang, Wei Zhang, Yue-Ting Deng, Ya-Ru Zhang, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: Cohort studies have shown inconsistent associations between omega-3 polyunsaturated fatty acids (n-3 PUFA) or fish oil and dementia risk. This study included a large number of participants and found that higher plasma levels of PUFA and fish oil supplementation were associated with a lower risk of developing dementia.
Article
Biochemistry & Molecular Biology
Shu-Yi Huang, Ya-Ru Zhang, Liu Yang, Yu-Zhu Li, Bang-Sheng Wu, Shi-Dong Chen, Jian-Feng Feng, Qiang Dong, Wei Cheng, Jin-Tai Yu
Summary: Identifying circulating metabolites associated with dementia, cognition, and brain volume could provide new insights into the pathogenesis of dementia. This cohort study found 26 metabolites associated with incident dementia, including specific associations with Alzheimer's disease (AD) and vascular dementia (VD). Circulating levels of certain lipoproteins were found to be associated with the risk of AD and AD phenotypes, while another lipoprotein was associated with the risk of VD.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ji-Yun Cheng, Yue-Ting Deng, Jin-Tai Yu
Summary: Through a more robust analysis, we found potential associations between circulating levels of amino acids and the risk of neurodegenerative diseases. Increase in circulating levels of Glutamine (Gln) was associated with lower risk of Alzheimer's disease (AD), while increase in circulating levels of Leucine (Leu) was associated with lower risk of Parkinson's disease (PD). Replication tests further confirmed the potential association between circulating Gln levels and AD risk.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Wei-Shi Liu, Ya-Ru Zhang, Yi-Jun Ge, Hui-Fu Wang, Wei Cheng, Jin-Tai Yu
Summary: This study identified the association between TREM2, temporal lobe, and AD using genetic and transcriptomic data, and explored the complex associations among inflammation, brain structure, and neurodegenerative disorders, particularly AD.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Hai-Shan Jiao, Peng Yuan, Jin-Tai Yu
Summary: Mutations in the TMEM106B gene are risk factors for various neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-of-function. However, mutations in TMEM106B increase its expression level, thus the molecular process linking these mutations to the apparent disruption in TMEM106B function remains mysterious.
MOLECULAR NEURODEGENERATION
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
