Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?

The Pathology of “Vascular Dementia”: A Critical Update

(2017) Kurt A. Jellinger   JOURNAL OF ALZHEIMERS DISEASE

Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

(2017) Laura B. Jaeger et al.   JOURNAL OF ALZHEIMERS DISEASE

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Immunotherapy for Alzheimer's Disease: Rational Basis in Ongoing Clinical Trials

(2011) Manuel Menendez-Gonzalez et al.   CURRENT PHARMACEUTICAL DESIGN

A perfect storm: Converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation

(2011) Jeffrey Noebels   EPILEPSIA

Evidence for a role of dystroglycan regulating the membrane architecture of astroglial endfeet

(2011) Susan Noell et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neurovascular function in Alzheimer's disease patients and experimental models

(2011) Nektaria Nicolakakis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of Anti-Inflammatory Therapy in a Model of Acute Seizures and in a Population of Pediatric Drug Resistant Epileptics

(2011) Nicola Marchi et al.   PLoS One

Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus

(2011) Kyung-Seok Han et al.   Molecular Brain

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

(2010) Costantino Iadecola   ACTA NEUROPATHOLOGICA

The neurovascular unit, matrix proteases, and innate inflammation

(2010) Gregory J. Del Zoppo   Annals of the New York Academy of Sciences

Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies

(2010) U Iqbal et al.   BRITISH JOURNAL OF CANCER

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Intact Memory in TGF-β1 Transgenic Mice Featuring Chronic Cerebrovascular Deficit: Recovery with Pioglitazone

(2010) Nektaria Nicolakakis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

(2010) Martin Lauritzen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CADASIL

(2010) D. Hervé et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Migraine aura pathophysiology: the role of blood vessels and microembolisation

(2010) Turgay Dalkara et al.   LANCET NEUROLOGY

Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-  in a Mouse Model of Alzheimer's Disease

(2010) A. M. S. Hartz et al.   MOLECULAR PHARMACOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Neurodegeneration and the neurovascular unit

(2010) Berislav V Zlokovic   NATURE MEDICINE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Review: Molecular genetics and pathology of hereditary small vessel diseases of the brain

(2010) Y. Yamamoto et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

(2010) J. Greenwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Introduction

(2010) C. Iadecola et al.   STROKE

Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain

(2009) Marie Monet-Leprêtre et al.   BRAIN

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage

(2009) J. P. Dreier et al.   BRAIN

Migraine and Genetic and Acquired Vasculopathies

(2009) AH Stam et al.   CEPHALALGIA

Cortical Spreading Depression—New Insights and Persistent Questions

(2009) A Charles et al.   CEPHALALGIA

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Blood–brain barrier breakdown-inducing astrocytic transformation: Novel targets for the prevention of epilepsy

(2009) Alon Friedman et al.   EPILEPSY RESEARCH

Blood-based biomarkers of microvascular pathology in Alzheimer’s disease

(2009) Michael Ewers et al.   EXPERIMENTAL GERONTOLOGY

Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke

(2009) Ken Arai et al.   FEBS Journal

Endothelial signaling in paracellular and transcellular leukocyte transmigration

(2009) Erika et al.   Frontiers in Bioscience-Landmark

Blood–brain barrier breakdown as a novel mechanism underlying cerebral hyperperfusion syndrome

(2009) Sebastian Ivens et al.   JOURNAL OF NEUROLOGY

ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood-Brain Barrier for A 1-40 Peptides

(2009) H. Xiong et al.   JOURNAL OF NEUROSCIENCE

Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?

(2009) Y. David et al.   JOURNAL OF NEUROSCIENCE

CADASIL

(2009) Hugues Chabriat et al.   LANCET NEUROLOGY

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

(2009) Vanja Vukic et al.   NEUROBIOLOGY OF DISEASE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical changes in cerebral small vessel diseases: a 3D MRI study of cortical morphology in CADASIL

(2008) E. Jouvent et al.   BRAIN

Targeting Extracellular Matrix Proteolysis for Hemorrhagic Complications of tPA Stroke Therapy

(2008) Xiaoying Wang et al.   CNS & Neurological Disorders-Drug Targets

Functional Role of Lipoprotein Receptors in Alzheimers Disease

(2008) Claus Pietrzik et al.   Current Alzheimer Research

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Thrombin Induces Long-Term Potentiation of Reactivity to Afferent Stimulation and Facilitates Epileptic Seizures in Rat Hippocampal Slices: Toward Understanding the Functional Consequences of Cerebrovascular Insults

(2008) N. Maggio et al.   JOURNAL OF NEUROSCIENCE

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

(2008) E. Candelario-Jalil et al.   NEUROSCIENCE

Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease

(2008) E. P. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE