β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

Complex noradrenergic dysfunction in Alzheimer’s disease: Low norepinephrine input is not always to blame

(2018) Mary Gannon et al.   BRAIN RESEARCH

Amyloid beta peptides, locus coeruleus-norepinephrine system and dense core vesicles

(2018) Jennifer A. Ross et al.   BRAIN RESEARCH

Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers

(2018) Mercedes Novo et al.   Scientific Reports

Treatment with D3 Removes Amyloid Deposits, Reduces Inflammation, and Improves Cognition in Aged AβPP/PS1 Double Transgenic Mice

(2018) Thomas van Groen et al.   JOURNAL OF ALZHEIMERS DISEASE

Advances in developing novel therapeutic strategies for Alzheimer’s disease

(2018) Jiqing Cao et al.   Molecular Neurodegeneration

The amyloid precursor protein modulates α2A-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitment

(2017) Fang Zhang et al.   FASEB JOURNAL

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

(2017) Juan Carlos Polanco et al.   Nature Reviews Neurology

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

(2017) Daniel J. Foster et al.   NEURON

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

(2016) Mudasir Maqbool et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure of ring-shaped Aβ42 oligomers determined by conformational selection

(2016) Linh Tran et al.   Scientific Reports

Noradrenergic dysfunction in Alzheimer's disease

(2015) Mary Gannon et al.   Frontiers in Neuroscience

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

α2Aadrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction

(2014) Yunjia Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice

(2013) Yuelong Liu et al.   HUMAN MOLECULAR GENETICS

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurabin Scaffolding of Adenosine Receptor and RGS4 Regulates Anti-Seizure Effect of Endogenous Adenosine

(2012) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilin

(2012) Christopher Cottingham et al.   NEUROPHARMACOLOGY

Drugs for Allosteric Sites on Receptors

(2011) Cody J. Wenthur et al.   Annual Review of Pharmacology and Toxicology

The Antidepressant Desipramine Is an Arrestin-biased Ligand at the α2A-Adrenergic Receptor Driving Receptor Down-regulationin Vitroandin Vivo

(2011) Christopher Cottingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A web-based normative calculator for the uniform data set (UDS) neuropsychological test battery

(2011) Steven D Shirk et al.   Alzheimers Research & Therapy

Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease

(2010) Terry L. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Hypotensive, Bradycardic, and Hypnotic Responses to  2-Adrenergic Agonists in Spinophilin-Null Mice Are Accompanied by Increased G Protein Coupling to the  2A-Adrenergic Receptor

(2010) R. Lu et al.   MOLECULAR PHARMACOLOGY

Prazosin for the Treatment of Behavioral Symptoms in Patients With Alzheimer Disease With Agitation and Aggression

(2009) Lucy Y. Wang et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome

(2009) Christopher J. Yuskaitis et al.   BIOCHEMICAL PHARMACOLOGY

Epitope-tagged Receptor Knock-in Mice Reveal That Differential Desensitization of α2-Adrenergic Responses Is because of Ligand-selective Internalization

(2009) Roujian Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

(2008) Alex E. Roher et al.   Alzheimers & Dementia

DARS (Decoys As the Reference State) Potentials for Protein-Protein Docking

(2008) Gwo-Yu Chuang et al.   BIOPHYSICAL JOURNAL

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis

(2008) Scott A. Small et al.   NEURON