Review
Pharmacology & Pharmacy
Andrew K. Evans, Erwin Defensor, Mehrdad Shamloo
Summary: This review examines the vulnerability mechanisms of locus coeruleus noradrenergic neurons, the impact of environmental and genetic factors on their risk, and potential interventions to reduce degeneration of these neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott, M. Kerry O'Banion
Summary: Gas6 overexpression reduces plaque burden but increases pro-inflammatory signaling and worsens behavior in an Alzheimer's disease model. Gas6 overexpression appears to have no effect on phagocytic mechanisms in vitro or in vivo.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Cell Biology
Stefania Merighi, Tino Emanuele Poloni, Anna Terrazzan, Eva Moretti, Stefania Gessi, Davide Ferrari
Summary: Alzheimer's disease is a prevalent neurodegenerative pathology, with links to adenosine and extracellular nucleotide activation which correlate to neuroinflammation and neurological damage. By studying the purinergic signaling regulated by P1 and P2, potential strategies for drug development can be explored.
Review
Biochemistry & Molecular Biology
Irene L. Gutierrez, Cinzia Dello Russo, Fabiana Novellino, Javier R. Caso, Borja Garcia-Bueno, Juan C. Leza, Jose L. M. Madrigal
Summary: This article summarizes the role of noradrenaline in Alzheimer's disease and suggests the use of noradrenaline-modulating drugs as a therapeutic option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Song Li, Che Wang, Zhen Wang, Jun Tan
Summary: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly population, characterized by beta-amyloid plaques and neurofibrillary tangles. Evidence suggests that cerebrovascular dysfunctions may play an important role in the development of AD, leading to potential new approaches for diagnosis, prevention, and treatment of the disease.
Review
Biology
Dilek Mercan, Michael Thomas Heneka
Summary: This article summarizes the important contribution of Locus coeruleus degeneration to the pathogenic progression of Alzheimer's disease (AD). Degeneration of LC leads to decreased noradrenaline levels, causing increased neuroinflammation, enhanced amyloid and tau burden, as well as impairment in cognition and synaptic plasticity.
Article
Immunology
Yanaika. S. S. Hok-A-Hin, Marta del Campo, Walter. A. A. Boiten, Erik Stoops, Melanie Vanhooren, Afina. W. W. Lemstra, Wiesje. M. M. van der Flier, Charlotte. E. E. Teunissen
Summary: The proteins MIF and sTREM1 show different levels of expression in different stages of Alzheimer's disease, and they are associated with tau pathology and inflammation. These neuroinflammatory markers could be useful in clinical trials to monitor the dynamics of inflammatory responses or the efficacy of inflammatory modulating drugs.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Benita Wiatrak, Katarzyna Balon, Paulina Jawien, Dominika Bednarz, Izabela Jeskowiak, Adam Szelag
Summary: With the increase in life expectancy, the number of patients with dementia, including Alzheimer's disease (AD), is growing. This review focuses on the potential association of AD with the digestive system, particularly the gut microbiota. The role of diet quality in preventing and alleviating Alzheimer's disease is also discussed, as well as the treatment strategies for changing the microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Stefania Merighi, Manuela Nigro, Alessia Travagli, Stefania Gessi
Summary: Neuroinflammation may be a crucial avenue for treating and preventing Alzheimer's disease, with microglia playing a key role in the disease process but potentially becoming impaired in later stages. It is important to identify new biomarkers to assess microglial activity and develop novel therapies to restore their physiological function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Dieli
Summary: The inflammatory response in Alzheimer's disease has both protective and harmful effects. Microglia initially play a protective role but can become overactivated, leading to impaired clearance of β-amyloid peptides and neurodegeneration. Microglia also contribute to the spread of tau pathology. Elevated levels of soluble TREM2 in cerebrospinal fluid are associated with amyloid plaque burden, neurodegeneration, and cognitive decline. Understanding the relationship between innate immunity and Alzheimer's disease could lead to new diagnostic and therapeutic approaches, but further studies are needed for effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Bartosz Twarowski, Mariola Herbet
Summary: Alzheimer's disease is an incurable form of senile dementia and a leading cause of death. Inflammation, specifically the release of mediators by inflammatory cells, can contribute to neuronal degeneration and disease progression in Alzheimer's. The pathomechanism of neuroinflammation in Alzheimer's disease is still not fully understood, but studying it could lead to the development of early diagnostic methods and new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Gennaro Bruno, Francesco De Logu, Daniel Souza Monteiro de Araujo, Angela Subbiani, Federica Lunardi, Sofia Rettori, Romina Nassini, Claudio Favre, Maura Calvani
Summary: The study found that beta-ARs play a role in cancer pain, with antagonists for beta 2-and beta 3-ARs slowing down mechanical allodynia and the development of macrophages, while also reducing the accumulation of oxidative stress byproducts.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Danique R. Hutten, Jens H. J. Bos, Stijn de Vos, Eelko Hak
Summary: This retrospective inception cohort study found that exposure to non-selective beta AR antagonists may increase the risk of developing Alzheimer's disease in older adults, while exposure to selective beta 2AR agonists may decrease the risk.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Pharmacology & Pharmacy
Rebecca F. Budgett, Geor Bakker, Eugenia Sergeev, Kirstie A. Bennett, Sophie J. Bradley
Summary: This article discusses the potential of mGlu(5) as a therapeutic target for neurodegenerative diseases and its role in neuroinflammatory responses, providing new possibilities for the treatment of neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Tao Ye, Shushu Yuan, Yu Kong, Huiqun Yang, Hongming Wei, Yuhe Zhang, Hangqi Jin, Qingxia Yu, Jiaming Liu, Songfang Chen, Jing Sun
Summary: This study found that the probiotic fungus Saccharomyces boulardii improves cognitive impairment in an Alzheimer's disease (AD) mouse model by regulating microglia-induced neuroinflammation. The results also showed fungal microbiota dysbiosis in APP/PS1 mice, which may be associated with neuroinflammation in AD.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Neurosciences
Carmen Lage, Andrea Gonzalez-Suarez, Maria Puerto Alcalde-Hierro, Maria Isabel Sampedro-Gonzalez, Maria Angeles Villanueva-Eguaras, Manuel Ruben Sanchez-Crespo, Catherine Widmann, Frederic Brosseron, Ana Pozueta, Sara Lopez-Garcia, Maria Garcia-Martinez, Martha Kazimierczak, Maria Bravo-Gonzalez, Andrea Fernandez-Rodriguez, Marta Drake-Perez, Juan Irure-Ventura, Marcos Lopez-Hoyos, Eloy Rodriguez-Rodriguez, Michael T. Heneka, Pascual Sanchez-Juan
Summary: Surgery may accelerate memory decline in cognitively asymptomatic individuals with preclinical Alzheimer's disease, especially in those with abnormal levels of amyloid-beta, while the presence of amyloid-beta does not seem to impact the overall incidence of perioperative neurocognitive disorders.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, Research & Experimental
Lily Keane, Ignazio Antignano, Sean-Patrick Riechers, Raphael Zollinger, Anaelle A. Dumas, Nina Offermann, Maria E. Bernis, Jenny Russ, Frederike Graelmann, Patrick Neil McCormick, Julia Esser, Dario Tejera, Ai Nagano, Jun Wang, Claude Chelala, Yvonne Biederbick, Annett Halle, Paolo Salomoni, Michael T. Heneka, Melania Capasso
Summary: Microglia in aged individuals show increased mTOR signaling and upregulation of inflammatory mediators, resulting in stronger responses to inflammatory stimuli. Genetic ablation of mTOR signaling can reduce microglia activation and inflammation response, alleviating sickness behavior in aged mice.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Correction
Immunology
Mihai G. Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y. Donath, Evangelos J. Giamarellos-Bourboulis, Douglas Golenbock, Mark S. Gresnigt, Michael T. Heneka, Hal M. Hoffman, Richard Hotchkiss, Leo A. B. Joosten, Daniel L. Kastner, Martin Korte, Eicke Latz, Peter Libby, Thomas Mandrup-Poulsen, Alberto Mantovani, Kingston H. G. Mills, Kristen L. Nowak, Luke A. O'Neill, Peter Pickkers, Tom van der Poll, Paul M. Ridker, Joost Schalkwijk, David A. Schwartz, Britta Siegmund, Clifford J. Steer, Herbert Tilg, Jos W. M. van der Meer, Frank L. van de Veerdonk, Charles A. Dinarello
Article
Immunology
Karin Odoj, Bianca Brawek, Nithi Asavapanumas, Nima Mojtahedi, Michael T. Heneka, Olga Garaschuk
Summary: Peripheral inflammation induces transient increase in neuronal activity in the early phase, while visual processing impairment occurs in the late phase. The specific cortical hyperactivity in the frontal/motor cortex may be caused by reduced cortical inhibition, and the impairment of sensory processing during resolution phase may be due to activated microglia.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Boris-Stephan Rauchmann, Ersin Ersoezlue, Sophia Stoecklein, Daniel Keeser, Frederic Brosseron, Katharina Buerger, Peter Dehent, Laura Dobisch, Birgit Ertl-Wagner, Klaus Fliessbach, John Dylan Haynes, Michael T. Heneka, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laake, Coraline D. Metzger, Matthias H. Munk, Oliver Peters, Josef Priller, Alfredo Ramirez, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan Teipl, Maike Tscheuschler, Ruth Vukovich, Michael Wagner, Jens Wiltfang, Renat Yakupov, Emrah Duezel, Frank Jessen, Robert Pernczky
Summary: By analyzing the brain network properties of various AD atrophy subtypes, we identified distinct differences in functional connectivity networks accompanied by CSF biomarker and cognitive differences.
Article
Biochemistry & Molecular Biology
Tatsuya Manabe, Ildiko Racz, Stephanie Schwartz, Linda Oberle, Francesco Santarelli, Julius Emmrich, Jonas J. Neher, Michael T. Heneka
Summary: Sepsis-associated encephalopathy (SAE) involves diverse cerebral dysfunctions in response to pathogen-induced systemic inflammation. Injection of LPS from different bacterial strains in aged mice resulted in short-term neuroinflammation with subsequent normalization, showing more pronounced inflammatory responses with E. coli LPS compared to Salmonella LPS. Reduction in excitatory synaptic puncta in the hippocampus was observed at a later time point, possibly attributed to microglia-mediated elimination of C3-tagged synapses.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris E. Jansen, Nancy L. Pedersen, Najada Stringa, Anna Zettergren, Isabel Hernandez, Laura Montrreal, Carmen Antunez, Anna Antonell, Rick M. Tankard, Joshua C. Bis, Rebecca Sims, Celine Bellenguez, Ines Quintela, Antonio Gonzalez-Perez, Miguel Calero, Emilio Franco-Macias, Juan Macias, Rafael Blesa, Laura Cervera-Carles, Manuel Menendez-Gonzalez, Ana Frank-Garcia, Jose Luis Royo, Fermin Moreno, Raquel Huerto Vilas, Miquel Baquero, Monica Diez-Fairen, Carmen Lage, Sebastian Garcia-Madrona, Pablo Garcia-Gonzalez, Emilio Alarcon-Martin, Sergi Valero, Oscar Sotolongo-Grau, Abbe Ullgren, Adam C. Naj, Afina W. Lemstra, Alba Benaque, Alba Perez-Cordon, Alberto Benussi, Alberto Rabano, Alessandro Padovani, Alessio Squassina, Alexandre de Mendonca, Alfonso Arias Pastor, Almar A. L. Kok, Alun Meggy, Ana Belen Pastor, Ana Espinosa, Anais Corma-Gomez, Angel Martin Montes, Angela Sanabria, Anita L. DeStefano, Anja Schneider, Annakaisa Haapasalo, Anne Kinhult Stahlbom, Anne Tybjaerg-Hansen, Annette M. Hartmann, Annika Spottke, Arturo Corbaton-Anchuelo, Arvid Rongve, Barbara Borroni, Beatrice Arosio, Benedetta Nacmias, Borge G. Nordestgaard, Brian W. Kunkle, Camille Charbonnier, Carla Abdelnour, Carlo Masullo, Carmen Martinez Rodriguez, Carmen Munoz-Fernandez, Carole Dufouil, Caroline Graff, Catarina B. Ferreira, Caterina Chillotti, Chandra A. Reynolds, Chiara Fenoglio, Christine Van Broeckhoven, Christopher Clark, Claudia Pisanu, Claudia L. Satizabal, Clive Holmes, Dolores Buiza-Rueda, Dag Aarsland, Dan Rujescu, Daniel Alcolea, Daniela Galimberti, David Wallon, Davide Seripa, Edna Gruenblatt, Efthimios Dardiotis, Emrah Duezel, Elio Scarpini, Elisa Conti, Elisa Rubino, Ellen Gelpi, Eloy Rodriguez-Rodriguez, Emmanuelle Duron, Eric Boerwinkle, Evelyn Ferri, Fabrizio Tagliavini, Fahri Kucukali, Florence Pasquier, Florentino Sanchez-Garcia, Francesca Mangialasche, Frank Jessen, Gael Nicolas, Geir Selbaek, Gemma Ortega, Genevieve Chene, Georgios Hadjigeorgiou, Giacomina Rossi, Gianfranco Spalletta, Giorgio Giaccone, Giulia Grande, Giuliano Binetti, Goran Papenberg, Harald Hampel, Henri Bailly, Henrik Zetterberg, Hilkka Soininen, Ida K. Karlsson, Ignacio Alvarez, Ildebrando Appollonio, Ina Giegling, Ingmar Skoog, Ingvild Saltvedt, Innocenzo Rainero, Irene Rosas Allende, Jakub Hort, Janine Diehl-Schmid, Jasper Van Dongen, Jean-Sebastien Vidal, Jenni Lehtisalo, Jens Wiltfang, Jesper Qvist Thomassen, Johannes Kornhuber, Jonathan L. Haines, Jonathan Vogelgsang, Juan A. Pineda, Juan Fortea, Julius Popp, Juergen Deckert, Katharina Buerger, Kevin Morgan, Klaus Fliessbach, Kristel Sleegers, Laura Molina-Porcel, Lena Kilander, Leonie Weinhold, Lindsay A. Farrer, Li-San Wang, Luca Kleineidam, Lucia Farotti, Lucilla Parnetti, Lucio Tremolizzo, Lucrezia Hausner, Luisa Benussi, Lutz Froelich, M. Arfan Ikram, M. Candida Deniz-Naranjo, Magda Tsolaki, Maitee Rosende-Roca, Malin Lowenmark, Marc Hulsman, Marco Spallazzi, Margaret A. Pericak-Vance, Margaret Esiri, Maria Bernal Sanchez-Arjona, Maria Carolina Dalmasso, Maria Teresa Martinez-Larrad, Marina Arcaro, Markus M. Noethen, Marta Fernandez-Fuertes, Martin Dichgans, Martin Ingelsson, Martin J. Herrmann, Martin Scherer, Martin Vyhnalek, Mary H. Kosmidis, Mary Yannakoulia, Matthias Schmid, Michael Ewers, Michael T. Heneka, Michael Wagner, Michela Scamosci, Miia Kivipelto, Mikko Hiltunen, Miren Zulaica, Montserrat Alegret, Myriam Fornage, Natalia Roberto, Natasja M. van Schoor, Nazib M. Seidu, Nerisa Banaj, Nicola J. Armstrong, Nikolaos Scarmeas, Norbert Scherbaum, Oliver Goldhardt, Oliver Hanon, Oliver Peters, Olivia Anna Skrobot, Olivier Quenez, Ondrej Lerch, Paola Bossu, Paolo Caffarra, Paolo Dionigi Rossi, Paraskevi Sakka, Per Hoffmann, Peter A. Holmans, Peter Fischer, Peter Riederer, Qiong Yang, Rachel Marshall, Rajesh N. Kalaria, Richard Mayeux, Rik Vandenberghe, Roberta Cecchetti, Roberta Ghidoni, Ruth Frikke-Schmidt, Sandro Sorbi, Sara Hagg, Sebastiaan Engelborghs, Seppo Helisalmi, Sigrid Botne Sando, Silke Kern, Silvana Archetti, Silvia Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Simon Mead, Simona Ciccone, Srdjan Djurovic, Stefanie Heilmann-Heimbach, Steffi Riedel-Heller, Teemu Kuulasmaa, Teodoro del Ser, Thibaud Lebouvier, Thomas Polak, Tiia Ngandu, Timo Grimmer, Valentina Bessi, Valentina Escott-Price, Vilmantas Giedraitis, Vincent Deramecourt, Wolfgang Maier, Xueqiu Jian, Yolande A. L. Pijnenburg, A. David Smith, C. Abdelnour, A. D. Adarmes-Gomez, C. Macleod, Iris E. Jansen, Patrick Gavin Kehoe, Guillermo Garcia-Ribas, Pascual Sanchez-Juan, Pau Pastor, Jordi Perez-Tur, Gerard Pinol-Ripoll, Adolfo Lopez de Munain, Jose Maria Garcia-Alberca, Maria J. Bullido, Victoria Alvarez, Alberto Lleo, Luis M. Real, Pablo Mir, Miguel Medina, Philip Scheltens, Henne Holstege, Marta Marquie, Maria Eugenia Saez, Angel Carracedo, Philippe Amouyel, Gerard D. Schellenberg, Julie Williams, Sudha Seshadri, Cornelia M. van Duijn, Karen A. Mather, Raquel Sanchez-Valle, Manuel Serrano-Rios, Adelina Orellana, Lluis Tarraga, Kaj Blennow, Martijn Huisman, Ole A. Andreassen, Danielle Posthuma, Jordi Clarimon, Merce Boada, Wiesje M. van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. van der Lee, Agustin Ruiz
Summary: This study identified 6 new genetic variants associated with Alzheimer's disease risk through a large-scale genetic association study. It also demonstrated the efficacy of a polygenic risk score in stratifying individuals at high risk of Alzheimer's disease, providing important data support for further research and preventive treatment of the disease.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Sofia Bergstrom, Julia Remnestal, Jamil Yousef, Jennie Olofsson, Ioanna Markaki, Stephanie Carvalho, Jean-Christophe Corvol, Kim Kultima, Lena Kilander, Malin Lowenmark, Martin Ingelsson, Kaj Blennow, Henrik Zetterberg, Bengt Nellgard, Frederic Brosseron, Michael T. Heneka, Beatriz Bosch, Raquel Sanchez-Valle, Anna Manberg, Per Svenningsson, Peter Nilsson
Summary: This study identified six proteins significantly increased in the CSF of AD patients and showed strong to moderate correlations with tau levels, suggesting their potential as candidate biomarkers for AD progression.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Environmental Sciences
Benjamin Aretz, Fanny Janssen, Judith M. Vonk, Michael T. Heneka, H. Marike Boezen, Gabriele Doblhammer
Summary: Exposure to PM2.5 was found to slow cognitive processing speed, especially weakly associated with respiratory function impairment, while the impact of BC was less significant. Lung function plays a certain mediating role in the relationship between PM2.5 and BC exposure and cognitive performance.
ENVIRONMENTAL RESEARCH
(2021)
Article
Neurosciences
Juan R. Perea, Marta Bolos, Raquel Cuadros, Esther Garcia, Vega Garcia-Escudero, Felix Hernandez, Roisin M. McManus, Michael T. Heneka, Jesus Avila
Summary: This study demonstrates that inhibiting p38 can attenuate the toxic effect of tau in microglia and enhance microglia-mediated tau phagocytosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Charlotte Braatz, Max P. Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Roisin M. McManus, Michael T. Heneka
Summary: Alzheimer's disease (AD) is characterized by the deposition of Amyloid-beta (Aβ) peptide, which leads to NLRP3 inflammasome activation and the release of interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). NLRP3-directed antisense oligonucleotides (ASOs) have been found to suppress NLRP3 inflammasome activity and IL-1β release in primary murine microglia and human THP-1 cells.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T. Heneka, Christina Ising
Summary: The highest risk factor for the development of tauopathies is aging. Senescent microglia have been identified in the brains of tau-transgenic mice and patients suffering from tauopathies. Exposure to tau can lead to microglial senescence, suggesting the presence of a vicious circle.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Shilauni Dadwal, Michael T. Heneka
Summary: Microglia, as the resident immune cells of the central nervous system, play critical roles in maintaining brain homeostasis, mediating cerebral immune responses, and neuroinflammation. Recent studies have shown that microglia consist of multiple subpopulations with unique properties, suggesting their specialized roles in different environments and diseases. Understanding microglial heterogeneity and their interactions with other cell types in the central nervous system offers promising therapeutic strategies for microglia-related pathologies.
Article
Clinical Neurology
Tommaso Ballarini, Debora Melo van Lent, Julia Brunner, Alina Schroeder, Steffen Wolfsgruber, Slawek Altenstein, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Emrah Duezel, Birgit Ertl-Wagner, Klaus Fliessbach, Silka Dawn Freiesleben, Ingo Frommann, Wenzel Glanz, Dietmar Hauser, John Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline Danielle Metzger, Matthias Munk, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Boris Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan J. Teipel, Ruth Vukovich, Jens Wiltfang, Frank Jessen, Michael Wagner
Summary: The study found a positive association between adherence to a Mediterranean-like diet and brain structure, cognitive function, and Alzheimer's disease-related biomarkers. Greater adherence to MeDi was linked to better memory, reduced AD pathology, and larger gray matter volume in the brain.
Article
Geriatrics & Gerontology
Francesca Mantile, Angelo Capasso, Nadia Villacampa, Maria Donnini, Giovanna L. Liguori, Gabriela Constantin, Piergiuseppe De Berardinis, Michael T. Heneka, Antonella Prisco
Summary: Immunization against Aβ is being explored for AD prevention, but current vaccines face challenges in safety and immunogenicity. While immunization with (1-11)E2 can induce antibody response, it does not protect against Aβ accumulation and neuroinflammation, highlighting the need for further research into the immune response against Aβ that could prevent accumulation.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
