Consequences of mitotic failure – The penalties and the rewards

Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

(2021) Yael Cohen-Sharir et al.   NATURE

Whole-genome doubling confers unique genetic vulnerabilities on tumour cells

(2021) Ryan J. Quinton et al.   NATURE

Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer

(2020) Anand Vasudevan et al.   DEVELOPMENTAL CELL

Chromosome arm aneuploidies shape tumour evolution and drug response

(2020) Ankit Shukla et al.   Nature Communications

Transcriptional effects of copy number alterations in a large set of human cancers

(2020) Arkajyoti Bhattacharya et al.   Nature Communications

A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity

(2020) Louisa Nelson et al.   Nature Communications

Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability

(2020) Noam Auslander et al.   Nature Communications

Keeping the Proportions of Protein Complex Components in Check

(2020) James Christopher Taggart et al.   Cell Systems

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

The landscape of chromothripsis across adult cancer types

(2020) Natalia Voronina et al.   Nature Communications

Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response

(2020) Sandrine Ragu et al.   Genes

Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

(2020) Shruti Singla et al.   Nature Communications

Pervasive chromosomal instability and karyotype order in tumour evolution

(2020) Thomas B. K. Watkins et al.   NATURE

P53 induces senescence in the unstable progeny of aneuploid cells

(2020) Maybelline Giam et al.   CELL CYCLE

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

(2020) John Michael Replogle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

(2019) Ana C. F. Bolhaqueiro et al.   NATURE GENETICS

Aneuploidy drives lethal progression in prostate cancer

(2019) Konrad H. Stopsack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

(2019) Christopher M. Brennan et al.   GENES & DEVELOPMENT

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Overdosage of Balanced Protein Complexes Reduces Proliferation Rate in Aneuploid Cells

(2019) Ying Chen et al.   Cell Systems

Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP 1 and PP 2A

(2019) James Holder et al.   FEBS LETTERS

Context is everything: aneuploidy in cancer

(2019) Uri Ben-David et al.   NATURE REVIEWS GENETICS

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

(2019) Emma Laks et al.   CELL

Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells

(2019) Maddalena Nano et al.   CURRENT BIOLOGY

Pan-cancer whole-genome analyses of metastatic solid tumours

(2019) Peter Priestley et al.   NATURE

Genetic predisposition to mosaic Y chromosome loss in blood

(2019) Deborah J. Thompson et al.   NATURE

Tetraploidy causes chromosomal instability in acentriolar mouse embryos

(2019) Lia Mara Gomes Paim et al.   Nature Communications

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

(2019) Maja Kneissig et al.   eLife

The enigma of monosomy 7

(2018) Toshiya Inaba et al.   BLOOD

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Cellular Stress Associated with Aneuploidy

(2018) Jin Zhu et al.   DEVELOPMENTAL CELL

Near-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness

(2018) Darawalee Wangsa et al.   FASEB JOURNAL

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability

(2018) Cristina Viganó et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Genome doubling shapes the evolution and prognosis of advanced cancers

(2018) Craig M. Bielski et al.   NATURE GENETICS

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

(2018) Joana Catarina Macedo et al.   Nature Communications

Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation

(2018) Yumi Uetake et al.   MOLECULAR BIOLOGY OF THE CELL

Human blastocysts of normal and abnormal karyotypes display distinct transcriptome profiles

(2018) Frederick Licciardi et al.   Scientific Reports

Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects

(2018) Qianqian He et al.   Oncogenesis

Genetic interactions between specific chromosome copy number alterations dictate complex aneuploidy patterns

(2018) Madhwesh C. Ravichandran et al.   GENES & DEVELOPMENT

The diverse consequences of aneuploidy

(2018) Narendra Kumar Chunduri et al.   NATURE CELL BIOLOGY

The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α

(2018) Susana Simões-Sousa et al.   Cell Reports

The PIDDosome activates p53 in response to supernumerary centrosomes

(2017) Luca L. Fava et al.   GENES & DEVELOPMENT

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures

(2017) Nicholas A Graham et al.   Molecular Systems Biology

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Mitotic spindle assembly in animal cells: a fine balancing act

(2017) Suzanna L. Prosser et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

(2017) Teresa Davoli et al.   SCIENCE

Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells

(2017) Yansheng Liu et al.   Nature Communications

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

(2017) Alexis R. Barr et al.   Nature Communications

Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation

(2017) Kelly D. Sullivan et al.   Scientific Reports

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

(2017) Mar Soto et al.   Cell Reports

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

(2017) Floris Foijer et al.   eLife

The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

(2017) Stefanos Aivazidis et al.   PLoS One

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

(2016) Erik McShane et al.   CELL

Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential

(2016) Meili Zhang et al.   EMBO JOURNAL

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

(2016) Sarah J. Pfau et al.   GENES & DEVELOPMENT

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

Profiling DNA damage response following mitotic perturbations

(2016) Ronni S. Pedersen et al.   Nature Communications

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

(2016) Tianli Xia et al.   Cell Reports

Trisomy 21 consistently activates the interferon response

(2016) Kelly D Sullivan et al.   eLife

Selective advantage of trisomic human cells cultured in non-standard conditions

(2016) Samuel D. Rutledge et al.   Scientific Reports

Whole Chromosome Instability induces senescence and promotes SASP

(2016) Grasiella Angelina Andriani et al.   Scientific Reports

Aneuploidy triggers a TFEB-mediated lysosomal stress response

(2015) Stefano Santaguida et al.   Autophagy

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells

(2015) Anastasia Y Kuznetsova et al.   CELL CYCLE

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion

(2015) J. K. Meena et al.   EMBO JOURNAL

The spindle checkpoint and chromosome segregation in meiosis

(2015) Gary J. Gorbsky   FEBS Journal

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Cell populations can use aneuploidy to survive telomerase insufficiency

(2015) Caroline Millet et al.   Nature Communications

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

(2015) Akihiro Ohashi et al.   Nature Communications

Chromosome mis-segregation and cytokinesis failure in trisomic human cells

(2015) Joshua M Nicholson et al.   eLife

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

Unique features of the transcriptional response to model aneuploidy in human cells

(2014) Milena Dürrbaum et al.   BMC GENOMICS

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells

(2014) N. Donnelly et al.   EMBO JOURNAL

The centrosome duplication cycle in health and disease

(2014) Erich A. Nigg et al.   FEBS LETTERS

Chromosomal instability causes sensitivity to metabolic stress

(2014) Z Shaukat et al.   ONCOGENE

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress

(2014) Floris Foijer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells

(2014) Uri Ben-David et al.   Nature Communications

Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

(2014) S. M. Dewhurst et al.   Cancer Discovery

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Gene Copy-Number Alterations: A Cost-Benefit Analysis

(2013) Yun-Chi Tang et al.   CELL

Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells

(2013) Christian Kuffer et al.   CHROMOSOMA

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements

(2013) C.-Z. Zhang et al.   GENES & DEVELOPMENT

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

(2013) A. D. Silk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

The in vitro survival of human monosomies and trisomies as embryonic stem cells

(2012) Juan Carlos Biancotti et al.   Stem Cell Research

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Repeated cleavage failure does not establish centrosome amplification in untransformed human cells

(2011) Anna Krzywicka-Racka et al.   JOURNAL OF CELL BIOLOGY

Timing of centrosome separation is important for accurate chromosome segregation

(2011) William T. Silkworth et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy

(2011) Michal Ozery-Flato et al.   GENOME BIOLOGY

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Illicit survival of cancer cells during polyploidization and depolyploidization

(2010) I Vitale et al.   CELL DEATH AND DIFFERENTIATION

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

(2010) K. A. Geiler-Samerotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Buffering of Segmental and Chromosomal Aneuploidies in Drosophila melanogaster

(2009) Per Stenberg et al.   PLoS Genetics

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

The consequences of tetraploidy and aneuploidy

(2008) Z. Storchova et al.   JOURNAL OF CELL SCIENCE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Effects of Aneuploidy on Genome Structure, Expression, and Interphase Organization in Arabidopsis thaliana

(2008) Bruno Huettel et al.   PLoS Genetics