Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

(2019) Anne Margriet Heijink et al.   Nature Communications

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

(2019) Triparna Sen et al.   Cancer Discovery

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment

(2019) Magnus T. Dillon et al.   CLINICAL CANCER RESEARCH

Exploiting DNA Replication Stress for Cancer Treatment

(2019) Tajinder Ubhi et al.   CANCER RESEARCH

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

(2019) Matthieu Gratia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

(2019) Timo Reisländer et al.   Nature Communications

DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging

(2019) Vinod Tiwari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling and cytotoxicity in BRCA2‐deficient cancer cells

(2019) Pepijn M. Schoonen et al.   Molecular Oncology

DNA damage responses in ageing

(2019) Paulo F. L. da Silva et al.   Open Biology

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability

(2019) Christy Hong et al.   Cells

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways

(2018) Annahita Sallmyr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

(2018) George E. Ronson et al.   Nature Communications

20 Years of Mre11 Biology: No End in Sight

(2018) Tanya T. Paull   MOLECULAR CELL

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

SAMHD1 acts at stalled replication forks to prevent interferon induction

(2018) Flavie Coquel et al.   NATURE

The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

(2018) Jennifer Ma et al.   Nature Communications

Mitochondria, Oxidative Stress and Innate Immunity

(2018) Yuxin Chen et al.   Frontiers in Physiology

PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer

(2018) Roman M. Chabanon et al.   JOURNAL OF CLINICAL INVESTIGATION

SAMHD1 and the innate immune response to cytosolic DNA during DNA replication

(2018) Flavie Coquel et al.   CURRENT OPINION IN IMMUNOLOGY

Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells

(2017) Ayeong So et al.   FEBS Journal

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

(2017) Erkin Erdal et al.   GENES & DEVELOPMENT

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

DNA damage-induced immune response: Micronuclei provide key platform

(2017) Nelson O. Gekara   JOURNAL OF CELL BIOLOGY

Sensing of dangerous DNA

(2017) Stephan Gasser et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair

(2017) Logan R. Myler et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

(2017) Giovanni Germano et al.   NATURE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RAD51 interconnects between DNA replication, DNA repair and immunity

(2017) Souparno Bhattacharya et al.   NUCLEIC ACIDS RESEARCH

Redox-sensitive alteration of replisome architecture safeguards genome integrity

(2017) Kumar Somyajit et al.   SCIENCE

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

(2017) Jarno Drost et al.   SCIENCE

Expanding functions of ADP-ribosylation in the maintenance of genome integrity

(2017) K. Martin-Hernandez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion

(2017) Priya Luthra et al.   mBio

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

(2017) Waaqo Daddacha et al.   Cell Reports

R Loops in the Regulation of Antibody Gene Diversification

(2017) Rushad Pavri   Genes

Fanconi Anemia Proteins Function in Mitophagy and Immunity

(2016) Rhea Sumpter et al.   CELL

The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells

(2016) Samantha S.W. Ho et al.   IMMUNITY

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

The role of neoantigens in response to immune checkpoint blockade

(2016) Nadeem Riaz et al.   INTERNATIONAL IMMUNOLOGY

RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

(2016) Vladislav Pokatayev et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

(2016) Eileen E. Parkes et al.   JNCI-Journal of the National Cancer Institute

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining

(2016) Martijn S. Luijsterburg et al.   MOLECULAR CELL

The nature of mutations induced by replication–transcription collisions

(2016) T. Sabari Sankar et al.   NATURE

NADPH oxidases: new actors in thyroid cancer?

(2016) Rabii Ameziane-El-Hassani et al.   Nature Reviews Endocrinology

Transcription–replication conflicts: how they occur and how they are resolved

(2016) Tatiana García-Muse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

(2016) Christine Wolf et al.   Nature Communications

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis

(2016) Philipp Seidel et al.   Oncotarget

Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents

(2016) Julie Gaston et al.   Oncotarget

Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer

(2016) Kyle C. Strickland et al.   Oncotarget

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

(2016) Tianli Xia et al.   Cell Reports

Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress

(2016) Therese Wilhelm et al.   PLoS Genetics

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

(2016) Eileen E. Parkes et al.   JNCI-Journal of the National Cancer Institute

DNA Damage Response and Immune Defense: Links and Mechanisms

(2016) Rania Nakad et al.   Frontiers in Genetics

Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production

(2016) Christelle Brégnard et al.   EBioMedicine

DNA Replication Stress as a Hallmark of Cancer

(2015) Morgane Macheret et al.   Annual Review of Pathology-Mechanisms of Disease

NBS1 is required for macrophage homeostasis and functional activity in mice

(2015) S. Pereira-Lopes et al.   BLOOD

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Human Disease Phenotypes Associated With Mutations in TREX1

(2015) Gillian I. Rice et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

(2015) Elizabeth E. Gray et al.   JOURNAL OF IMMUNOLOGY

The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation

(2015) Mandar Bawadekar et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells

(2015) Yu J. Shen et al.   Cell Reports

DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function

(2015) Qiujing Yu et al.   Cell Reports

DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation

(2015) Jana Prochazkova et al.   PLoS Genetics

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

(2015) Dipanjan Dutta et al.   PLoS Pathogens

Replication Stress in Mammalian Cells and Its Consequences for Mitosis

(2015) Camille Gelot et al.   Genes

RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma

(2014) Adeline R. Lam et al.   CANCER RESEARCH

Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease

(2014) Jeonghyun Ahn et al.   CURRENT OPINION IN IMMUNOLOGY

The clinical impact of deficiency in DNA non-homologous end-joining

(2014) Lisa Woodbine et al.   DNA REPAIR

The Mre11/Rad50/Nbs1 complex: Recent insights into catalytic activities and ATP-driven conformational changes

(2014) Tanya T. Paull et al.   EXPERIMENTAL CELL RESEARCH

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Apurinic/Apyrimidinic Endonuclease 2 Regulates the Expansion of Germinal Centers by Protecting against Activation-Induced Cytidine Deaminase–Independent DNA Damage in B Cells

(2014) Jeroen E. J. Guikema et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation

(2014) Qifan Zhu et al.   JOURNAL OF IMMUNOLOGY

IgH Chain Class Switch Recombination: Mechanism and Regulation

(2014) Janet Stavnezer et al.   JOURNAL OF IMMUNOLOGY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production

(2014) Susanne Roth et al.   NATURE IMMUNOLOGY

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

The causes of replication stress and their consequences on genome stability and cell fate

(2014) Indiana Magdalou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inflammation-driven carcinogenesis is mediated through STING

(2014) Jeonghyun Ahn et al.   Nature Communications

PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination-Mediated DNA Repair

(2014) Y. Hu et al.   Cancer Discovery

Altered mucosal immune response after acute lung injury in a murine model of Ataxia Telangiectasia

(2014) Olaf Eickmeier et al.   BMC Pulmonary Medicine

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

(2014) Xu Zhang et al.   Cell Reports

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

(2014) Mireille Bétermier et al.   PLoS Genetics

Is homologous recombination really an error-free process?

(2014) Josée Guirouilh-Barbat et al.   Frontiers in Genetics

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases: A Perspective on Reactive Oxygen Species Production in Tumor Biology

(2013) Jennifer L. Meitzler et al.   ANTIOXIDANTS & REDOX SIGNALING

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria

(2013) Ismene Karakasilioti et al.   Cell Metabolism

How unfinished business from S-phase affects mitosis and beyond

(2013) Hocine W Mankouri et al.   EMBO JOURNAL

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

(2013) Nuno Figueiredo et al.   IMMUNITY

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Molecular Basis of DNA Recognition in the Immune System

(2013) M. K. Atianand et al.   JOURNAL OF IMMUNOLOGY

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells

(2013) T. Wilhelm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair

(2013) M. Robu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Postreplicative Mismatch Repair

(2013) J. Jiricny   Cold Spring Harbor Perspectives in Biology

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining

(2013) Anastazja Grabarz et al.   Cell Reports

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1

(2012) S. Ying et al.   CANCER RESEARCH

Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome

(2012) Makoto Goto et al.   EXPERIMENTAL GERONTOLOGY

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis

(2012) Mariko Murata et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

(2012) Alex Pines et al.   JOURNAL OF CELL BIOLOGY

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation–Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group

(2012) Kathryn Alsop et al.   JOURNAL OF CLINICAL ONCOLOGY

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualization of a DNA-PK/PARP1 complex

(2012) Laura Spagnolo et al.   NUCLEIC ACIDS RESEARCH

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation

(2012) Aswin Mangerich et al.   Oxidative Medicine and Cellular Longevity

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Mammalian mismatch repair: error-free or error-prone?

(2012) Javier Peña-Diaz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

Defective DNA double-strand break repair in pediatric systemic lupus erythematosus

(2011) Robert C. Davies et al.   ARTHRITIS AND RHEUMATISM

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity

(2011) B. C. Burnette et al.   CANCER RESEARCH

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Linking RNA Polymerase Backtracking to Genome Instability in E. coli

(2011) Dipak Dutta et al.   CELL

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses

(2011) Ramachander V.N. Turaga et al.   CELL CYCLE

Aicardi-Goutieres syndrome: from patients to genes and beyond

(2011) C Chahwan et al.   CLINICAL GENETICS

Premature aging and cancer in nucleotide excision repair-disorders

(2011) K. Diderich et al.   DNA REPAIR

PARP-1 enhances the mismatch-dependence of 5′-directed excision in human mismatch repair in vitro

(2011) Yiyong Liu et al.   DNA REPAIR

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN

(2011) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Activation of Interferon-Stimulated Genes by  -Ray Irradiation Independently of the Ataxia Telangiectasia Mutated-p53 Pathway

(2011) T. Sugihara et al.   MOLECULAR CANCER RESEARCH

SNPs in DNA repair genes associated to meningitis and host immune response

(2011) Thayse Azevedo da Silva et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis

(2011) Dominique Ziech et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Co-directional replication–transcription conflicts lead to replication restart

(2011) Houra Merrikh et al.   NATURE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin

(2010) Michel Lebel et al.   Annals of the New York Academy of Sciences

Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection

(2010) Tanya T. Paull   DNA REPAIR

The MRN complex in double-strand break repair and telomere maintenance

(2010) Brandon J. Lamarche et al.   FEBS LETTERS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Co-Orientation of Replication and Transcription Preserves Genome Integrity

(2010) Anjana Srivatsan et al.   PLoS Genetics

The structural biochemistry of the superoxide dismutases

(2009) J.J.P. Perry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Aicardi-Goutieres syndrome

(2009) S. Orcesi et al.   BRITISH MEDICAL BULLETIN

DNA Repair in Mammalian Cells

(2009) T. Nouspikel   CELLULAR AND MOLECULAR LIFE SCIENCES

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

(2009) Y. J. Crow et al.   HUMAN MOLECULAR GENETICS

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Multiple functions of MRN in end-joining pathways during isotype class switching

(2009) Maria Dinkelmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

(2009) Anyong Xie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Structural and Functional Relationships of the XPF/MUS81 Family of Proteins

(2008) Alberto Ciccia et al.   Annual Review of Biochemistry

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining

(2008) Mirjam van der Burg et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevalence and clinical associations of anti-Ku antibodies in systemic autoimmune diseases

(2008) I Cavazzana et al.   LUPUS

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A homologous recombination defect affects replication-fork progression in mammalian cells

(2007) F. Daboussi et al.   JOURNAL OF CELL SCIENCE