Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells

Causes and consequences of protein folding stress in aneuploid cells

(2015) Neysan Donnelly et al.   CELL CYCLE

Unique features of the transcriptional response to model aneuploidy in human cells

(2014) Milena Dürrbaum et al.   BMC GENOMICS

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

Proteogenomic characterization of human colon and rectal cancer

(2014) Bing Zhang et al.   NATURE

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

(2014) Norman Ertych et al.   NATURE CELL BIOLOGY

Comparison of the Cancer Gene Targeting and Biochemical Selectivities of All Targeted Kinase Inhibitors Approved for Clinical Use

(2014) Joost C. M. Uitdehaag et al.   PLoS One

Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

(2014) S. M. Dewhurst et al.   Cancer Discovery

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells

(2012) Lei Lv et al.   CELL CYCLE

Cancer chromosomal instability: therapeutic and diagnostic challenges

(2012) Nicholas McGranahan et al.   EMBO REPORTS

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast

(2012) Jin Zhu et al.   PLoS Genetics

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

(2011) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Repeated cleavage failure does not establish centrosome amplification in untransformed human cells

(2011) Anna Krzywicka-Racka et al.   JOURNAL OF CELL BIOLOGY

The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications

(2010) Veerle Melotte et al.   FASEB JOURNAL

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

(2009) Samuel F. Bakhoum et al.   CURRENT BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

The consequences of tetraploidy and aneuploidy

(2008) Z. Storchova et al.   JOURNAL OF CELL SCIENCE

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE