Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP 1 and PP 2A

PLK1 plays dual roles in centralspindlin regulation during cytokinesis

(2019) Ingrid E. Adriaans et al.   JOURNAL OF CELL BIOLOGY

The RIF1-PP1 Axis Controls Abscission Timing in Human Cells

(2019) Rahul Bhowmick et al.   CURRENT BIOLOGY

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

(2019) Bert van de Kooij et al.   eLife

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

(2018) Isha Nasa et al.   Science Signaling

iASPP–PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation

(2018) Kun Gao et al.   Cell Death & Disease

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

(2018) Isha Nasa et al.   Science Signaling

Protein phosphatases in the regulation of mitosis

(2018) Jakob Nilsson   JOURNAL OF CELL BIOLOGY

A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase

(2017) Sierra N. Cullati et al.   JOURNAL OF CELL BIOLOGY

Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis

(2017) Jamin B. Hein et al.   NATURE CELL BIOLOGY

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

(2017) Beata E. Mierzwa et al.   NATURE CELL BIOLOGY

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)

(2017) Claudio Alfieri et al.   Open Biology

Two Bistable Switches Govern M Phase Entry

(2016) Satoru Mochida et al.   CURRENT BIOLOGY

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit

(2016) Michael J. Cundell et al.   JOURNAL OF CELL BIOLOGY

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells

(2016) Samuel Rogers et al.   JOURNAL OF CELL SCIENCE

Greatwall dephosphorylation and inactivation upon mitotic exit is triggered by PP1

(2016) Sheng Ma et al.   JOURNAL OF CELL SCIENCE

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

(2016) Emil Peter Thrane Hertz et al.   MOLECULAR CELL

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

(2016) Masaya Yamaguchi et al.   MOLECULAR CELL

Molecular mechanism of APC/C activation by mitotic phosphorylation

(2016) Suyang Zhang et al.   NATURE

Molecular basis of APC/C regulation by the spindle assembly checkpoint

(2016) Claudio Alfieri et al.   NATURE

Mechanism of APC/CCDC20activation by mitotic phosphorylation

(2016) Renping Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding the PP2A Interactome by Defining a B56-Specific SLiM

(2016) Xinru Wang et al.   STRUCTURE

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization

(2016) Jiao Wang et al.   Protein & Cell

The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

(2015) Barbara Di Fiore et al.   DEVELOPMENTAL CELL

Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit

(2015) A. Heim et al.   EMBO REPORTS

The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth

(2015) C. Winkler et al.   JOURNAL OF CELL SCIENCE

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs

(2015) Rachael A. McCloy et al.   MOLECULAR & CELLULAR PROTEOMICS

Spatiotemporal regulation of the anaphase-promoting complex in mitosis

(2015) Sushama Sivakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch

(2015) Junbin Qian et al.   Nature Communications

Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression

(2015) Rosa Della Monica et al.   eLife

Cytokinetic Abscission: Molecular Mechanisms and Temporal Control

(2014) Beata Mierzwa et al.   DEVELOPMENTAL CELL

KIF4A and PP2A–B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle

(2014) Ricardo Nunes Bastos et al.   JOURNAL OF CELL BIOLOGY

A PP1–PP2A phosphatase relay controls mitotic progression

(2014) Agnes Grallert et al.   NATURE

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

(2014) Sigrid B. Thoresen et al.   NATURE CELL BIOLOGY

Feedback control of chromosome separation by a midzone Aurora B gradient

(2014) O. Afonso et al.   SCIENCE

Cdk1 Coordinates Timely Activation of MKlp2 Kinesin with Relocation of the Chromosome Passenger Complex for Cytokinesis

(2014) Mayumi Kitagawa et al.   Cell Reports

PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit

(2014) Nadia Hégarat et al.   PLoS Genetics

Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

(2014) Byron C Williams et al.   eLife

Marking and Measuring Single Microtubules by PRC1 and Kinesin-4

(2013) Radhika Subramanian et al.   CELL

Enclosing Chromatin: Reassembly of the Nucleus after Open Mitosis

(2013) Cornelia Wandke et al.   CELL

Aurora B Defines Its Own Chromosomal Targeting by Opposing the Recruitment of the Phosphatase Scaffold Repo-Man

(2013) Junbin Qian et al.   CURRENT BIOLOGY

CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state

(2013) Karen E. Gascoigne et al.   JOURNAL OF CELL BIOLOGY

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A

(2013) Ricardo Nunes Bastos et al.   JOURNAL OF CELL BIOLOGY

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression

(2013) T. Kruse et al.   JOURNAL OF CELL SCIENCE

The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation

(2013) Michael J. Cundell et al.   MOLECULAR CELL

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

(2013) Jeremiah J Frye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals

(2013) M. Alvarez-Fernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression

(2013) P. Xu et al.   Biology Open

Protein phosphatases and their regulation in the control of mitosis

(2012) Satoru Mochida et al.   EMBO REPORTS

The PP1 binding code: a molecular-lego strategy that governs specificity

(2012) Ewald Heroes et al.   FEBS Journal

Condensins: universal organizers of chromosomes with diverse functions

(2012) T. Hirano   GENES & DEVELOPMENT

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

(2012) Ricardo Nunes Bastos et al.   JOURNAL OF CELL BIOLOGY

Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry

(2012) K. A. Blake-Hodek et al.   MOLECULAR AND CELLULAR BIOLOGY

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis

(2012) Sergey Lekomtsev et al.   NATURE

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C

(2012) J. G. Carlton et al.   SCIENCE

The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis

(2012) L. Capalbo et al.   Open Biology

A Quantitative Model for Ordered Cdk Substrate Dephosphorylation during Mitotic Exit

(2011) Céline Bouchoux et al.   CELL

The nucleolar phosphataseCdc14Bis dispensable for chromosome segregation and mitotic exit in human cells

(2011) Eli Berdougo et al.   CELL CYCLE

PP1/Repo-Man Dephosphorylates Mitotic Histone H3 at T3 and Regulates Chromosomal Aurora B Targeting

(2011) Junbin Qian et al.   CURRENT BIOLOGY

Repo-Man Coordinates Chromosomal Reorganization with Nuclear Envelope Reassembly during Mitotic Exit

(2011) Paola Vagnarelli et al.   DEVELOPMENTAL CELL

Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

(2011) Tamara A. Potapova et al.   MOLECULAR BIOLOGY OF THE CELL

Cortical Constriction During Abscission Involves Helices of ESCRT-III-Dependent Filaments

(2011) J. Guizetti et al.   SCIENCE

A Minimal Midzone Protein Module Controls Formation and Length of Antiparallel Microtubule Overlaps

(2010) Peter Bieling et al.   CELL

Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein

(2010) Radhika Subramanian et al.   CELL

MASTL is the human ortholog of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis

(2010) Erik Voets et al.   CELL CYCLE

Aurora B and 14-3-3 Coordinately Regulate Clustering of Centralspindlin during Cytokinesis

(2010) Max E. Douglas et al.   CURRENT BIOLOGY

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

Human Cdc14A Phosphatase Modulates the G2/M Transition through Cdc25A and Cdc25B

(2010) María D. Vázquez-Novelle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission

(2010) Ricardo Nunes Bastos et al.   JOURNAL OF CELL BIOLOGY

How cyclin A destruction escapes the spindle assembly checkpoint

(2010) Barbara Di Fiore et al.   JOURNAL OF CELL BIOLOGY

Activation of cyclin B1–Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

(2010) Olivier Gavet et al.   JOURNAL OF CELL BIOLOGY

Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair

(2010) Annamaria Mocciaro et al.   JOURNAL OF CELL BIOLOGY

Cdc14: a highly conserved family of phosphatases with non-conserved functions?

(2010) A. Mocciaro et al.   JOURNAL OF CELL SCIENCE

Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle

(2010) T. Lorca et al.   JOURNAL OF CELL SCIENCE

Regulated Degradation of Spindle Assembly Factors by the Anaphase-Promoting Complex

(2010) Ling Song et al.   MOLECULAR CELL

Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei

(2010) Raquel A. Oliveira et al.   NATURE CELL BIOLOGY

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

(2010) Michael H. A. Schmitz et al.   NATURE CELL BIOLOGY

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

(2010) Michael J Ragusa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

(2010) Yuya Yamagishi et al.   SCIENCE

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Cdk1 Negatively Regulates Midzone Localization of the Mitotic Kinesin Mklp2 and the Chromosomal Passenger Complex

(2009) Stefan Hümmer et al.   CURRENT BIOLOGY

Greatwall maintains mitosis through regulation of PP2A

(2009) Suzanne Vigneron et al.   EMBO JOURNAL

Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

(2009) Satoru Mochida et al.   EMBO JOURNAL

The M Phase Kinase Greatwall (Gwl) Promotes Inactivation of PP2A/B55δ, a Phosphatase Directed Against CDK Phosphosites

(2009) Priscila V. Castilho et al.   MOLECULAR BIOLOGY OF THE CELL

PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation

(2009) Judy Qiju Wu et al.   NATURE CELL BIOLOGY

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

(2009) Mark E. Burkard et al.   PLOS BIOLOGY

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation

(2009) Benjamin A. Wolfe et al.   PLOS BIOLOGY

The Hunt for Cyclin

(2008) Peter K. Jackson   CELL

APC/CCdh1 Targets Aurora Kinase to Control Reorganization of the Mitotic Spindle at Anaphase

(2008) Suzanne Floyd et al.   CURRENT BIOLOGY

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APCCdh1 in G1 phase

(2008) Geneviève Rodier et al.   EMBO JOURNAL

Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication

(2008) Jun Wu et al.   JOURNAL OF CELL BIOLOGY

The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase

(2008) Agnidipta Ghosh et al.   MOLECULAR CELL

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A

(2008) Rob Wolthuis et al.   MOLECULAR CELL

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

(2008) Yanhui Xu et al.   MOLECULAR CELL

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

(2008) Brian G. Fuller et al.   NATURE

Spatial and temporal coordination of mitosis by Ran GTPase

(2008) Paul R. Clarke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The 3Ms of central spindle assembly: microtubules, motors and MAPs

(2008) Michael Glotzer   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release

(2008) J. G. Carlton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Rac by the GAP Activity of Centralspindlin Is Essential for Cytokinesis

(2008) J. C. Canman et al.   SCIENCE