Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression

Metformin monotherapy in melanoma: a pilot, open-label, prospective, and multicentric study indicates no benefit

(2017) Henri Montaudié et al.   Pigment Cell & Melanoma Research

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

(2017) Patrick A. Eyers et al.   TRENDS IN CELL BIOLOGY

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

(2017) Patrick Ming-Kuen Tang et al.   Nature Communications

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

(2016) Lianfeng Wu et al.   CELL

Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer

(2016) Reema Wahdan-Alaswad et al.   CELL CYCLE

Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial

(2016) Takuma Higurashi et al.   LANCET ONCOLOGY

The real role of pseudokinase: linking diabetes to cancers

(2016) Ke Li et al.   Cancer Medicine

Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis

(2015) Michal Tomcik et al.   ANNALS OF THE RHEUMATIC DISEASES

Metformin in Cancer Treatment and Prevention

(2015) Daniel R. Morales et al.   Annual Review of Medicine

Metformin Addition to Chemotherapy in Stage IV Non-Small Cell Lung Cancer: an Open Label Randomized Controlled Study

(2015) Rana Sayed et al.   Asian Pacific Journal of Cancer Prevention

The TRIB3-SQSTM1 interaction mediates metabolic stress-promoted tumorigenesis and progression via suppressing autophagic and proteasomal degradation

(2015) Fang Hua et al.   Autophagy

Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway

(2015) Takahisa Takino et al.   CLINICAL & EXPERIMENTAL METASTASIS

Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial

(2015) Sil Kordes et al.   LANCET ONCOLOGY

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality

(2015) Emily Jane Gallagher et al.   PHYSIOLOGICAL REVIEWS

Metformin upregulates E-cadherin and inhibits B16F10 cell motility, invasion and migration

(2015) GUANZHAO LIANG et al.   Oncology Letters

Metformin Use and Prostate Cancer Risk

(2014) Mark A. Preston et al.   EUROPEAN UROLOGY

Structural Basis for Phosphorylation and Lysine Acetylation Cross-talk in a Kinase Motif Associated with Myocardial Ischemia and Cardioprotection

(2014) Benjamin L. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is it time to test biguanide metformin in the treatment of melanoma?

(2014) Michael Cerezo et al.   Pigment Cell & Melanoma Research

Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force

(2013) F. Polet et al.   JOURNAL OF INTERNAL MEDICINE

Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

(2013) M. Cerezo et al.   MOLECULAR CANCER THERAPEUTICS

Knockdown of TRB3 induces apoptosis in human lung adenocarcinoma cells through regulation of Notch 1 expression

(2013) HUI ZHOU et al.   Molecular Medicine Reports

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

(2013) H. A. Hirsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGF  pathways as fundamental Notch regulators in breast cancer

(2013) J. Izrailit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repositioning metformin for cancer prevention and treatment

(2013) Brendan J. Quinn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival

(2012) Guangdi Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

ASEB: a web server for KAT-specific acetylation site prediction

(2012) L. Wang et al.   NUCLEIC ACIDS RESEARCH

Metformin Accelerates the Growth of BRAF V600E -Driven Melanoma by Upregulating VEGF-A

(2012) Matthew J. Martin et al.   Cancer Discovery

In vitro and in vivo anti-melanoma action of metformin

(2011) Kristina Janjetovic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRB3 interacts with SMAD3 promoting tumor cell migration and invasion

(2011) F. Hua et al.   JOURNAL OF CELL SCIENCE

Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

(2011) Franziska Niehr et al.   Journal of Translational Medicine

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

(2011) T Tomic et al.   Cell Death & Disease

Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathway

(2010) Han Xiao et al.   CARDIOVASCULAR RESEARCH

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Metformin: Taking away the candy for cancer?

(2010) Mathilde Jalving et al.   EUROPEAN JOURNAL OF CANCER