标题
Autophagy in the liver: functions in health and disease
作者
关键词
-
出版物
Nature Reviews Gastroenterology & Hepatology
Volume 14, Issue 3, Pages 170-184
出版商
Springer Nature
发表日期
2017-01-05
DOI
10.1038/nrgastro.2016.185
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury
- (2016) Shaogui Wang et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells
- (2016) Atsushi Umemura et al. CANCER CELL
- The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
- (2016) Lynne Chantranupong et al. CELL
- Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver
- (2016) Nuria Martinez-Lopez et al. Cell Metabolism
- The peroxisome as a cell signaling organelle
- (2016) Durga Nand Tripathi et al. CURRENT OPINION IN CELL BIOLOGY
- Starch Binding Domain-containing Protein 1 Plays a Dominant Role in Glycogen Transport to Lysosomes in Liver
- (2016) Tao Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
- (2016) Fiorenza Fumagalli et al. NATURE CELL BIOLOGY
- Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
- (2016) Benjamin Richter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ubiquitin-Dependent And Independent Signals In Selective Autophagy
- (2016) Aliaksandr Khaminets et al. TRENDS IN CELL BIOLOGY
- p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
- (2016) Tetsuya Saito et al. Nature Communications
- Autophagy and Lipid Droplets in the Liver
- (2015) Nuria Martinez-Lopez et al. Annual Review of Nutrition
- ROS-dependent signal transduction
- (2015) Colleen R Reczek et al. CURRENT OPINION IN CELL BIOLOGY
- Autophagy Mediates HBx-Induced Nuclear Factor-κB Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes
- (2015) Millore X.M. Luo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The role for autophagy in cancer
- (2015) Eileen White JOURNAL OF CLINICAL INVESTIGATION
- Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
- (2015) Jennifer Jung et al. MOLECULAR AND CELLULAR BIOLOGY
- PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins
- (2015) David G. McEwan et al. MOLECULAR CELL
- The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
- (2015) Jin-Mi Heo et al. MOLECULAR CELL
- ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes
- (2015) Jiajie Diao et al. NATURE
- Regulation of endoplasmic reticulum turnover by selective autophagy
- (2015) Aliaksandr Khaminets et al. NATURE
- Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
- (2015) Keisuke Mochida et al. NATURE
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
- (2015) Manuele Rebsamen et al. NATURE
- ATM functions at the peroxisome to induce pexophagy in response to ROS
- (2015) Jiangwei Zhang et al. NATURE CELL BIOLOGY
- Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
- (2015) Susmita Kaushik et al. NATURE CELL BIOLOGY
- Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
- (2015) S. Wang et al. SCIENCE
- Sestrin2 is a leucine sensor for the mTORC1 pathway
- (2015) R. L. Wolfson et al. SCIENCE
- Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation
- (2015) B Liu et al. Cell Death & Disease
- Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt
- (2015) Heidi L. Kenerson et al. PLoS One
- The role of autophagy in neonatal tissues: Just a response to amino acid starvation?
- (2014) Stefano Schiaffino et al. Autophagy
- Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation
- (2014) Bo Liu et al. Autophagy
- The carbohydrate-binding domain of overexpressed STBD1 is important for its stability and protein–protein interactions
- (2014) Yuanqi Zhu et al. BIOSCIENCE REPORTS
- Hif-2α Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy
- (2014) Katharina M. Walter et al. Cell Metabolism
- Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1
- (2014) Seung-Hyun Ro et al. FEBS Journal
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
- (2014) Lesley A. Kane et al. JOURNAL OF CELL BIOLOGY
- Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy
- (2014) Hong-Min Ni et al. JOURNAL OF HEPATOLOGY
- Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently Infected Endothelial Cells through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1
- (2014) Olsi Gjyshi et al. JOURNAL OF VIROLOGY
- Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy
- (2014) Vladimir Rogov et al. MOLECULAR CELL
- Ubiquitin is phosphorylated by PINK1 to activate parkin
- (2014) Fumika Koyano et al. NATURE
- Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
- (2014) Yasushi Totoki et al. NATURE GENETICS
- Fluphenazine Reduces Proteotoxicity in C. elegans and Mammalian Models of Alpha-1-Antitrypsin Deficiency
- (2014) Jie Li et al. PLoS One
- Regulation of mTORC1 by amino acids
- (2014) Liron Bar-Peled et al. TRENDS IN CELL BIOLOGY
- Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
- (2014) Á González-Rodríguez et al. Cell Death & Disease
- A dual role for autophagy in a murine model of lung cancer
- (2014) Shuan Rao et al. Nature Communications
- Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers
- (2014) Hwan-Woo Park et al. Nature Communications
- SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer
- (2013) Lianjie Li et al. CANCER CELL
- Autophagy and human diseases
- (2013) Peidu Jiang et al. CELL RESEARCH
- Autophagy regulation by nutrient signaling
- (2013) Ryan C Russell et al. CELL RESEARCH
- Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency
- (2013) Nunzia Pastore et al. EMBO Molecular Medicine
- Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice
- (2013) Heidi L. Kenerson et al. GASTROENTEROLOGY
- Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
- (2013) J. Y. Guo et al. GENES & DEVELOPMENT
- Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice
- (2013) Rohit A. Sinha et al. HEPATOLOGY
- Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease
- (2013) Yuka Fukuo et al. HEPATOLOGY RESEARCH
- Differential Contribution of Insulin and Amino Acids to the mTORC1-Autophagy Pathway in the Liver and Muscle
- (2013) Takako Naito et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin
- (2013) Naonobu Fujita et al. JOURNAL OF CELL BIOLOGY
- Decoding cell death signals in liver inflammation
- (2013) Catherine Brenner et al. JOURNAL OF HEPATOLOGY
- Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice
- (2013) Chih-Wen Lin et al. JOURNAL OF HEPATOLOGY
- Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-treated rats: an immunohistochemical and electron microscopic study
- (2013) Nabil Eid et al. JOURNAL OF MOLECULAR HISTOLOGY
- Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
- (2013) Yoshinobu Ichimura et al. MOLECULAR CELL
- p53 status determines the role of autophagy in pancreatic tumour development
- (2013) Mathias T. Rosenfeldt et al. NATURE
- Autophagosomes form at ER–mitochondria contact sites
- (2013) Maho Hamasaki et al. NATURE
- TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
- (2013) Carmine Settembre et al. NATURE CELL BIOLOGY
- MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
- (2013) Eyleen J. O’Rourke et al. NATURE CELL BIOLOGY
- Liver autophagy: much more than just taking out the trash
- (2013) Jaime L. Schneider et al. Nature Reviews Gastroenterology & Hepatology
- Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1
- (2013) D. N. Tripathi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
- (2013) Louis R. Lapierre et al. Nature Communications
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma
- (2012) Jianhua Ling et al. CANCER CELL
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes
- (2012) Eisuke Itakura et al. CELL
- Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
- (2012) Jung Min Han et al. CELL
- Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation
- (2012) Bérengère Coupé et al. Cell Metabolism
- Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage
- (2012) Soo Han Bae et al. Cell Metabolism
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues
- (2012) Virginia Hernández–Gea et al. GASTROENTEROLOGY
- The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism
- (2012) Xiwen Xiong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Replication of Hepatitis C Virus RNA on Autophagosomal Membranes
- (2012) Donna Sir et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NBR1 acts as an autophagy receptor for peroxisomes
- (2012) E. Deosaran et al. JOURNAL OF CELL SCIENCE
- Redox implications of AMPK-mediated signal transduction beyond energetic clues
- (2012) S. Cardaci et al. JOURNAL OF CELL SCIENCE
- Glutaminolysis Activates Rag-mTORC1 Signaling
- (2012) Raúl V. Durán et al. MOLECULAR CELL
- Keap1 degradation by autophagy for the maintenance of redox homeostasis
- (2012) K. Taguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
- Autophagic activity in thymus and liver during aging
- (2011) Mohammad Nizam Uddin et al. AGE
- Changes in Autophagic Response in Patients with Chronic Hepatitis C Virus Infection
- (2011) Pierre-Emmanuel Rautou et al. AMERICAN JOURNAL OF PATHOLOGY
- A Review of α1-Antitrypsin Deficiency
- (2011) James K. Stoller et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- The Role of Atg Proteins in Autophagosome Formation
- (2011) Noboru Mizushima et al. Annual Review of Cell and Developmental Biology
- Liver autophagy contributes to the maintenance of blood glucose and amino acid levels
- (2011) Junji Ezaki et al. Autophagy
- Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1
- (2011) Sixin Jiang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
- (2011) Aikseng Ooi et al. CANCER CELL
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
- (2011) Julie Adam et al. CANCER CELL
- Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance
- (2011) Susmita Kaushik et al. Cell Metabolism
- Autophagy-deficient mice develop multiple liver tumors
- (2011) A. Takamura et al. GENES & DEVELOPMENT
- Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
- (2011) Keiko Taguchi et al. GENES TO CELLS
- Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
- (2011) Yoshihiro Inami et al. JOURNAL OF CELL BIOLOGY
- Autophagy Required for Hepatitis B Virus Replication in Transgenic Mice
- (2011) Y. Tian et al. JOURNAL OF VIROLOGY
- Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment
- (2011) J. Li et al. JOURNAL OF VIROLOGY
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Starvation Induced Cell Death in Autophagy-Defective Yeast Mutants Is Caused by Mitochondria Dysfunction
- (2011) Sho W. Suzuki et al. PLoS One
- Ammonia-induced autophagy is independent of ULK1/ULK2 kinases
- (2011) H. Cheong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- p62+ Hyaline Inclusions in Intrahepatic Cholangiocarcinoma Associated With Viral Hepatitis or Alcoholic Liver Disease
- (2010) Shinichi Aishima et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- Under the ROS: Thiol network is the principal suspect for autophagy commitment
- (2010) Giuseppe Filomeni et al. Autophagy
- Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
- (2010) Ling Yang et al. Cell Metabolism
- Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice
- (2010) Wen–Xing Ding et al. GASTROENTEROLOGY
- Starch Binding Domain-containing Protein 1/Genethonin 1 Is a Novel Participant in Glycogen Metabolism
- (2010) Sixin Jiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
- (2010) Ashish Jain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy
- (2010) Wei-Lien Yen et al. JOURNAL OF CELL BIOLOGY
- Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes
- (2010) P. Ferraris et al. JOURNAL OF GENERAL VIROLOGY
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- (2010) A. Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
- (2010) Shomit Sengupta et al. NATURE
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Plasma membrane contributes to the formation of pre-autophagosomal structures
- (2010) Brinda Ravikumar et al. NATURE CELL BIOLOGY
- Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
- (2010) Ying Zhao et al. NATURE CELL BIOLOGY
- The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
- (2010) D. Sir et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Autophagy-Enhancing Drug Promotes Degradation of Mutant 1-Antitrypsin Z and Reduces Hepatic Fibrosis
- (2010) T. Hidvegi et al. SCIENCE
- Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy
- (2010) C. H. Eng et al. Science Signaling
- Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection
- (2010) Carl Guévin et al. VIROLOGY
- 3D tomography reveals connections between the phagophore and endoplasmic reticulum
- (2009) Päivi Ylä-Anttila et al. Autophagy
- Knockdown of autophagy-related gene decreases the production of infectious Hepatitis C virus particles
- (2009) Isei Tanida et al. Autophagy
- Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
- (2009) Paul Nicklin et al. CELL
- Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia
- (2009) Hui-Yu Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
- (2009) Nao Hosokawa et al. MOLECULAR BIOLOGY OF THE CELL
- ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
- (2009) Chang Hwa Jung et al. MOLECULAR BIOLOGY OF THE CELL
- Mantle skewness and ridge segmentation
- (2009) Satish C. Singh et al. NATURE
- A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
- (2009) Mitsuko Hayashi-Nishino et al. NATURE CELL BIOLOGY
- Dynamics and diversity in autophagy mechanisms: lessons from yeast
- (2009) Hitoshi Nakatogawa et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The autophagy machinery is required to initiate hepatitis C virus replication
- (2009) M. Dreux et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
- (2009) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis
- (2008) Angeles Duran et al. CANCER CELL
- Mechanisms of Hepatic Fibrogenesis
- (2008) Scott L. Friedman GASTROENTEROLOGY
- Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation
- (2008) Masaru Harada et al. HEPATOLOGY
- A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
- (2008) Yi Liu et al. NATURE
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
- (2008) I. H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes
- (2008) P. K. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy Is Essential for Preimplantation Development of Mouse Embryos
- (2008) S. Tsukamoto et al. SCIENCE
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