Review
Biochemistry & Molecular Biology
Silviu Stanciu, Florentina Ionita-Radu, Constantin Stefani, Daniela Miricescu, Iulia-Ioana Stanescu-Spinu, Maria Greabu, Alexandra Ripszky Totan, Mariana Jinga
Summary: Pancreatic cancer, although relatively rare, is becoming a leading cause of cancer death. Various risk factors, both modifiable and non-modifiable, contribute to its pathogenesis. Chronic inflammation plays a crucial role in the development of pancreatic cancer. The PI3K/AKT/mTOR signaling pathway is important in cell growth, survival, and motility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Junhe Li, Wei Huang, Qing Han, Jianping Xiong, Zhiwang Song
Summary: LDLRAD2 acts as an oncogene in pancreatic cancer by modulating the Akt/mTOR signaling pathway, contributing to cell proliferation, migration, and invasion inhibition, as well as suppressing EMT.
Article
Cell Biology
Yanyi Xiao, Yilong Liu, Zhiwei Gao, Xian Li, Min Weng, Chenghao Shi, Cheng Wang, Linxiao Sun
Summary: Pancreatic cancer is a highly malignant tumor with increasing chemotherapeutic resistance, posing a challenge in clinical treatment. Fisetin, extracted from vegetables and fruits, shows potential as an anti-cancer agent for pancreatic cancer by targeting the PI3K/AKT/mTOR signaling cascade. Further research is needed to better understand the molecular mechanisms underlying fisetin's anti-cancer effects on pancreatic cancer.
Article
Multidisciplinary Sciences
Fuchun Yang, Shiva Kalantari, Banzhan Ruan, Shaogang Sun, Zhaoqun Bian, Jun-Lin Guan
Summary: The study demonstrates that autophagy inhibition can block the progression of lymphatic malformation (LM) to lymphangiosarcoma (LAS) by regulating osteopontin expression and Jak/Stat3 signaling. Additionally, it shows that specifically disrupting FIP200 canonical autophagy function can also block LM progression to LAS.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Hiroki Kajioka, Shunsuke Kagawa, Atene Ito, Masashi Yoshimoto, Shuichi Sakamoto, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Yuzo Umeda, Kazuhiro Noma, Hiroshi Tazawa, Toshiyoshi Fujiwara
Summary: Surgery is the primary curative treatment for pancreatic cancer, but postsurgical recurrence is common. Inflammation caused by surgery, neutrophils, and neutrophil extracellular traps (NETs) play important roles in cancer metastasis. Targeting NETs with thrombomodulin may be a novel strategy to improve surgical outcomes for pancreatic cancer patients.
Article
Biotechnology & Applied Microbiology
Tianyu Dai, Junhui Liang, Wei Liu, Yonghui Zou, Feifei Niu, Mengqing Li, Haomeng Zhang, Changzhong Li, Mingjun Fan, Guoying Cui
Summary: The study found that miRNA miR-582-3p is downregulated in ovarian cancer, and knockdown of miR-582-3p promotes proliferation and migration of OC cells while overexpression inhibits their development. Long non-coding RNA TUG1 binds to miR-582-3p and plays a negative regulatory role in the progression of OC. The AKT/mTOR signaling pathway suppresses the malignant properties of OC through targeting lncRNA TUG1.
Article
Medicine, Research & Experimental
Madhuri Dutta, Biswajit Das, Debasish Mohapatra, Padmanava Behera, Shantibhusan Senapati, Anasuya Roychowdhury
Summary: This study reveals the potential of hsa-miR-217 in inhibiting pancreatic cancer progression by targeting ATAD2 and inactivating the AKT signaling pathway.
Article
Biochemistry & Molecular Biology
Iram Fatima, Susmita Barman, JayaPrakash Uppada, Shailender Chauhan, Sanchita Rauth, Satyanarayana Rachagani, Moorthy Palanimuthu Ponnusamy, Lynette Smith, Geoffrey Talmon, Amar B. Singh, Surinder K. Batra, Punita Dhawan
Summary: This study reveals a critical role of MASTL in promoting pancreatic cancer malignancy and therapy resistance by modulating protein stability and kinase signaling. Combinatorial therapy targeting MASTL enhances the cell-killing effects of Gemcitabine, demonstrating its potential as a novel target to improve sensitivity to anti-pancreatic cancer therapies.
Review
Agriculture, Multidisciplinary
Mengyuan Li, Zuomin Hu, Tianyi Guo, Tiantian Xie, Yanqin Tang, Xiuxiu Wu, Feijun Luo
Summary: Cancer poses a serious public health problem, and traditional treatments often have unavoidable side effects. Natural products with wide sources and low toxicity are gaining attention for their therapeutic effects. Polysaccharides have been shown to have potential in fighting cancer, but the molecular mechanisms are not well understood. Recent studies indicate that dietary polysaccharides play a vital role in cancer prevention and treatment by regulating the mammalian target of rapamycin (mTOR) pathway. This article systematically summarizes the progress in targeting mTOR signaling by dietary polysaccharides in cancer prevention and their molecular mechanisms, providing valuable references for investigators in this cutting-edge field.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Oncology
Kei Takahashi, Shogo Ehata, Kensuke Miyauchi, Yasuyuki Morishita, Keiji Miyazawa, Kohei Miyazono
Summary: The study identified NTSR1 as a potential prognostic marker and molecular target for pancreatic cancer treatment, as its overexpression was associated with poor prognosis and increased tumorigenic and metastatic abilities. Additionally, NTS stimulation activated the MAPK and NF-kappa B signaling pathways in highly malignant cancer sublines and revealed new target genes for NTS in pancreatic cancer cells. Treatment with a selective NTSR1 antagonist suppressed the activation of these pathways and attenuated the tumorigenicity of pancreatic cancer cells.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huang Chen, Aiwu Bian, Lian-fang Yang, Xuan Yin, Jie Wang, Chaowen Ti, Ying Miao, Shihong Peng, Shifen Xu, Mingyao Liu, Wen-Wei Qiu, Zhengfang Yi
Summary: A new small-molecule inhibitor N4 shows potent anti-tumor bioactivity in pancreatic cancer by targeting STAT3, effectively suppressing tumor growth and metastasis, and potentially offering clinical benefits for treatment.
Article
Biochemistry & Molecular Biology
Shixin Chan, Xu Wang, Zhenglin Wang, Youwen Du, Xiaomin Zuo, Jiajie Chen, Rui Sun, Qing Zhang, Li Lin, Yang Yang, Zhen Yu, Hu Zhao, Huabing Zhang, Wei Chen
Summary: This study found that CTSG expression is inhibited in colorectal cancer tissues, and patients with low CTSG expression have poor overall survival. Functional experiments showed that CTSG overexpression suppressed CRC cell progression, while CTSG suppression supported CRC development. Mechanistically, CTSG overexpression suppressed the Akt/mTOR signaling mechanism and elevated apoptotic-associated markers, while CTSG silencing activated the Akt/mTOR signaling mechanism and inhibited apoptotic-associated markers.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biology
Lei Cao, Hongsheng Liu, Cheng Huang, Chao Guo, Luo Zhao, Chao Gao, Yuan Xu, Guige Wang, Naixin Liang, Shanqing Li
Summary: This study aimed to investigate the mechanisms of lung cancer and develop an effective therapeutic approach. The researchers found that USP5 is highly expressed in lung cancer and promotes the proliferation and migration of lung cancer cells through the PARP1-mediated mTOR signaling pathway. Silencing USP5 significantly reduced the volume of subcutaneous tumors, while overexpression of USP5 and shRARP1 treatment led to a significant increase and decrease in tumor size, respectively. These findings suggest that USP5 could be a potential new target for lung cancer treatment.
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Cell Biology
Ming Xu, Xianglan Zhang, Songnan Zhang, Junjie Piao, Yang Yang, Xinyue Wang, Zhenhua Lin
Summary: SPOCK1 plays a crucial role in breast cancer progression by promoting cell proliferation and metastasis, making it a promising clinical therapeutic target for preventing the progression of breast cancer.
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)