Article
Cell Biology
Lin Xu, Xinge Zhang, Yue Xin, Jie Ma, Chenyan Yang, Xi Zhang, Guoqing Hou, Xiaocheng Charlie Dong, Zhaoli Sun, Xiwen Xiong, Xuan Cao
Summary: The reduction of DEPDC5 in the livers of ethanol-fed mice or ALD patients leads to aberrant activation of mTORC1. Elimination of DEPDC5 results in liver injury and steatosis, but protects against diet-induced liver steatosis.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Maria Jesus Valero-Aracama, Antonio Reboreda, Alberto Arboit, Magdalena Sauvage, Motoharu Yoshida
Summary: Persistent firing is considered a cellular correlate of working memory, where it is shown to be supported by cholinergic receptor activation in hippocampal CA1 pyramidal cells and suppressed by noradrenaline (NA). The inhibitory effect of NA on persistent firing is mediated through the cAMP-PKA pathway and activation of beta 1 and/or beta 3 adrenergic receptors, with high levels of NA and cAMP implicated in working memory decline under conditions such as high stress, aging, and schizophrenia.
Article
Cell Biology
Lufei Wang, Lichi Han, Peng Xue, Xiangxiang Hu, Sing-Wai Wong, Meng Deng, Henry C. Tseng, Bo-Wen Huang, Ching-Chang Ko
Summary: The study found that dopamine inhibits osteoclast differentiation through the D2R/cAMP/PKA/CREB pathway. This reveals a potential mechanism for how the nervous system impacts bone remodeling and suggests future research directions for understanding bone development, repair, aging, and degenerative diseases.
CELLULAR SIGNALLING
(2021)
Article
Chemistry, Medicinal
Sang-Hyun Ahn, Jung-Soo Suh, Yoon-Kwan Jang, Heon-Su Kim, Gyu-Ho Choi, Eunhye Kim, Tae-Jin Kim
Summary: This study demonstrates that the ethanol extract from Rhynchosia volubilis can protect cells against apoptosis by activating the cAMP-PKA/ERK-CREB pathway.
Article
Pharmacology & Pharmacy
Xiahenazi Aiyasiding, Hai-Han Liao, Hong Feng, Nan Zhang, Zheng Lin, Wen Ding, Han Yan, Zi-Ying Zhou, Qi-Zhu Tang
Summary: This study revealed that LQ alleviates pressure overload-induced cardiac hypertrophy in vivo and inhibits Ang II-induced cardiomyocyte hypertrophy in vitro via activating cAMP/PKA/LKB1/AMPKα2 signaling. These findings suggest that LQ might be a valuable adjunct to therapeutic approaches for treating pathological cardiac remodeling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Havva Afshari, Shokoofe Noori, Afshin Zarghi
Summary: Resveratrol and metformin combination therapy reduces hepatic steatosis by inducing autophagy via the cAMP/AMPK/SIRT1 signaling pathway.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sadiq Nasrah, Aline Radi, Johanna K. Daberkow, Helmut Hummler, Stefanie Weber, Elie Seaayfan, Martin Koemhoff
Summary: Melanoma-associated antigen D2 (MAGED2) activates the cAMP/PKA pathway under hypoxic conditions, stimulating renal salt reabsorption and explaining the transient variant of Bartter's syndrome. MAGED2 depletion leads to upregulation of autophagy-related genes and accumulation of autophagosome marker LC3II, indicating an inhibitory role of MAGED2 in autophagy under stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qifu He, Feng Gao, Shenghui Wu, Shaowen Wang, Zhiming Xu, Xuerui Xu, Tianyang Lan, Kang Zhang, Fusheng Quan
Summary: In dairy goat farming, increasing the female kid rate is economically beneficial. Alkaline incubation enriches the concentration of X-chromosome-bearing sperm, but the mechanism by which pH affects this sperm's motility remains unclear. This study revealed that the sAC/cAMP/PKA signaling pathway plays a role in influencing sperm motility, as inhibiting its protease activity resulted in decreased motility. The results suggest that alkaline dilution incubation slows down the motility of X-sperm through reduced Ca2+ entry, providing a theoretical foundation for further optimization of sex control methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Beibei Guo, Mengwei Qi, Shuai Huang, Run Zhuo, Wenxue Zhang, Yufang Zhang, Man Xu, Mei Liu, Tuchen Guan, Yan Liu
Summary: The study identified Cadherin-12 (CDH12) as a gene that promotes neurite outgrowth by affecting Rac1/Cdc42 phosphorylation. This research provides a preliminary explanation for the mechanism of CDH12 in promoting axonal extension in vitro and in vivo.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guillaume Bastin, Lemieux Luu, Battsetseg Batchuluun, Alexandra Mighiu, Stephanie Beadman, Hangjung Zhang, Changhao He, Dana Al Rijjal, Michael B. Wheeler, Scott P. Heximer
Summary: RGS4 protein plays a crucial role in regulating insulin secretion in response to glucose stimulation, with its deficiency leading to impaired insulin secretion, reduced cAMP/PKA activity, and abnormal calcium oscillations in pancreatic beta-cells. These findings highlight the significance of maintaining normal levels of RGS4 function for proper insulin secretion in healthy pancreatic tissues.
Article
Nutrition & Dietetics
Jeong-Hyun Yoon, Kumju Youn, Mira Jun
Summary: Melanogenic effects of pinostrobin, a flavanone found in honey, were evaluated in this study. Pinostrobin was found to increase melanin levels and tyrosinase activity by stimulating the expression of melanogenic regulatory factors. Computational simulations also revealed the potential pharmacokinetic properties of pinostrobin. The study suggests that pinostrobin could be a potent and safe melanogenic agent for depigmentation disorders.
Article
Multidisciplinary Sciences
Di Xie, Fan Chen, Yuanyuan Zhang, Bei Shi, Jiahui Song, Kiran Chaudhari, Shao-Hua Yang, Gary J. Zhang, Xiaoli Sun, Hugh S. Taylor, Da Li, Yingqun Huang
Summary: This study investigates the mechanism of action of metformin, a frontline antidiabetic drug, in inhibiting glucose production in hepatocytes. The researchers found that metformin up-regulates microRNA let-7, which in turn down-regulates TET3, leading to a change in the ratio of hepatocyte nuclear factor 4 alpha (HNF4 alpha) isoforms and subsequent inhibition of gluconeogenic genes. They also demonstrated that let-7-mediated mechanism is faithfully recapitulated in mice with type 2 diabetes treated with therapeutic doses of metformin. The findings suggest that reactivation of the let-7-dependent pathway could be a major mechanism of metformin action and liver-specific delivery of let-7 may represent a potential therapeutic for type 2 diabetes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
Ranran Wang, Lulu Wei, Junaid Wazir, Li Li, Shiyu Song, Kai Lin, Wenyuan Pu, Chen Zhao, Zhonglan Su, Quan Zhao, Hongwei Wang
Summary: Curcumin improves adipose atrophy in cancer cachexia by inhibiting the cAMP/PKA/CREB signaling pathway. The study shows that curcumin protects mice with C26 tumors and cachexia from weight loss and adipose atrophy, reducing levels of free fatty acids and increasing triglyceride levels. Curcumin also ameliorates CL316243-induced adipose atrophy and inhibits hormone-mediated PKA and CREB activation.
Article
Agriculture, Multidisciplinary
Qin Li, Yunqin Shen, Xingyue Guo, Yixuan Xu, Yuheng Mao, Yinfan Wu, Fang He, Caixia Wang, Yanqiu Chen, Yan Yang
Summary: Betanin can dose-dependently alleviate allergic asthma and upregulate the cAMP-PKA-CREB pathway. This study provides a novel nutritional strategy for the treatment of allergic asthma.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
An Pan, Xiao-Meng Sun, Feng-Qing Huang, Jin-Feng Liu, Yuan-Yuan Cai, Xin Wu, Raphael N. Alolga, Ping Li, Bao-Lin Liu, Qun Liu, Lian-Wen Qi
Summary: Disordered hepatic glucagon response is a contributing factor to hyperglycemia in diabetes. This study reveals that the mitochondrial beta-oxidation enzyme HADHA promotes the production of beta-hydroxybutyrate, which negatively regulates hepatic gluconeogenesis during glucagon challenge by targeting HDAC7. Activation of HADHA or elevation of beta-hydroxybutyrate levels through pharmacological intervention may hold promise in the treatment of diabetes.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Iris R. Hartley, Julia Costa Beber Nunes, Maya Lodish, Constantine A. Stratakis
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2019)
Article
Peripheral Vascular Disease
Andrea G. Maria, Mari Suzuki, Annabel Berthon, Crystal Kamilaris, Andrew Demidowich, Justin Lack, Mihail Zilbermint, Fady Hannah-Shmouni, Fabio R. Faucz, Constantine A. Stratakis
AMERICAN JOURNAL OF HYPERTENSION
(2020)
Editorial Material
Pediatrics
Constantine A. Stratakis, Scott A. Rivkees
PEDIATRIC RESEARCH
(2020)
Editorial Material
Endocrinology & Metabolism
Constantine A. Stratakis
HORMONE AND METABOLIC RESEARCH
(2020)
Article
Oncology
Ivana Jochmanova, April Melody T. Abcede, Ruby Jane S. Guerrero, Chandy Lou P. Malong, Robert Wesley, Huynh Thanh, Melissa K. Gonzales, Katherine I. Wolf, Abhishek Jha, Marianne Knue, Tamara Prodanov, Naris Nilubol, Leilani B. Mercado-Asis, Constantine A. Stratakis, Karel Pacak
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Article
Endocrinology & Metabolism
Amit Tirosh, Harish RaviPrakash, Georgios Z. Papadakis, Christina Tatsi, Elena Belyavskaya, Lyssikatos Charalampos, Maya B. Lodish, Ulas Bagci, Constantine A. Stratakis
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Cell Biology
Marie Helene Schernthaner-Reiter, Giampaolo Trivellin, Constantine A. Stratakis
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Afrouz Anderson, Andrea Gropman, Cynthia Le Mons, Constantine Stratakis, Amir Gandjbakhche
MOLECULAR GENETICS AND METABOLISM
(2020)
Review
Medicine, General & Internal
Christina Tatsi, Constantine A. Stratakis
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Emilia Modolo Pinto, Fabio R. Faucz, Luana Z. Paza, Gang Wu, Elizabeth S. Fernandes, Jerome Bertherat, Constantine A. Stratakis, Enzo Lalli, Raul C. Ribeiro, Carlos Rodriguez-Galindo, Bonald C. Figueiredo, Gerard P. Zambetti
Review
Endocrinology & Metabolism
Fady Hannah-Shmouni, Constantine A. Stratakis
HORMONE AND METABOLIC RESEARCH
(2020)
Article
Pediatrics
Amanda C. Swart, Therina du Toit, Evgenia Gourgari, Martin Kidd, Meg Keil, Fabio R. Faucz, Constantine A. Stratakis
Summary: Using UPC2-MS/MS technology, a distinct subgroup of PCOS patients with adrenal abnormalities has been successfully identified, showing significant changes in steroid ratios. The newly discovered steroid metabolites may serve as novel biomarkers for diagnosing PCOS patients with adrenal abnormalities.
PEDIATRIC RESEARCH
(2021)
Editorial Material
Endocrinology & Metabolism
Sarantis Livadas, Constantine A. Stratakis, Djuro Macut
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Rachel Wurth, Crystal Kamilaris, Naris Nilubol, Samira M. Sadowski, Annabel Berthon, Martha M. Quezado, Fabio R. Faucz, Constantine A. Stratakis, Fady Hannah-Shmouni
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2020)
Meeting Abstract
Medicine, General & Internal
M. Rescigno, C. Tatsi, C. Lyssikatos, E. Belyavskaya, M. Keil, G. Papadakis, C. Stratakis
JOURNAL OF INVESTIGATIVE MEDICINE
(2020)