Chemistry of Lipid A: At the Heart of Innate Immunity

Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide

(2013) Daniel Artner et al.   ACS Chemical Biology

Reprint of “New complete structure of Hafnia alvei clinical isolate strain PCM 2670 semi-rough lipopolysaccharide”

(2013) Ewelina Bobko et al.   CARBOHYDRATE RESEARCH

Elucidation of a novel lipid A α-(1,1)-GalA transferase gene (rgtF) from Mesorhizobium loti: Heterologous expression of rgtF causes Rhizobium etli to synthesize lipid A with α-(1,1)-GalA

(2013) Dusty B Brown et al.   GLYCOBIOLOGY

Toll-like receptor agonists: current status and future perspective on their utility as adjuvants in improving antic ancer vaccination strategies

(2013) Constantin N Baxevanis et al.   Immunotherapy

Toll-like Receptor 4 (TLR4) Modulation by Synthetic and Natural Compounds: An Update

(2013) Francesco Peri et al.   JOURNAL OF MEDICINAL CHEMISTRY

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Structure of lipid A from a stem-nodulating bacterium Azorhizobium caulinodans

(2012) Adam Choma et al.   CARBOHYDRATE RESEARCH

Recent Approaches to Novel Antibacterials Designed After LPS Structure and Biochemistry

(2012) Luca Gabrielli et al.   CURRENT DRUG TARGETS

Aminoarabinose is essential for lipopolysaccharide export and intrinsic antimicrobial peptide resistance inBurkholderia cenocepacia†

(2012) Mohamad A. Hamad et al.   MOLECULAR MICROBIOLOGY

Synthetic Toll Like Receptor-4 (TLR-4) Agonist Peptides as a Novel Class of Adjuvants

(2012) Arulkumaran Shanmugam et al.   PLoS One

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist

(2012) W. S. Bowen et al.   Science Signaling

The Lipopolysaccharide Core of Brucella abortus Acts as a Shield Against Innate Immunity Recognition

(2012) Raquel Conde-Álvarez et al.   PLoS Pathogens

Lipid Lateral Organization on Giant Unilamellar Vesicles Containing Lipopolysaccharides

(2011) Jakubs Kubiak et al.   BIOPHYSICAL JOURNAL

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

New Targets for Antibacterial Design: Kdo Biosynthesis and LPS Machinery Transport to the Cell Surface

(2011) L. Cipolla et al.   CURRENT MEDICINAL CHEMISTRY

A variety of novel lipid A structures obtained from Francisella tularensis live vaccine strain

(2011) Ashley S Beasley et al.   Innate Immunity

Reflectron MALDI TOF and MALDI TOF/TOF mass spectrometry reveal novel structural details of native lipooligosaccharides

(2011) Luisa Sturiale et al.   JOURNAL OF MASS SPECTROMETRY

Understanding the molecular interactions of lipopolysaccharides during E. coli initial adhesion with a surface forces apparatus

(2011) Qingye Lu et al.   Soft Matter

Enediol mimics as inhibitors of the d-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis

(2010) Alejandra Yep et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Corrigendum to ‘‘Lipopolysaccharide structures from Agrobacterium and Rhizobiaceae species’’ [Carbohydr. Res. 343 (2009) 1924–1933]

(2010) Cristina De Castro et al.   CARBOHYDRATE RESEARCH

Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design

(2010) Chul-Jin Lee et al.   CHEMISTRY & BIOLOGY

The Structure of a Novel Neutral Lipid A from the Lipopolysaccharide of Bradyrhizobium elkanii Containing Three Mannose Units in the Backbone

(2010) Iwona Komaniecka et al.   CHEMISTRY-A EUROPEAN JOURNAL

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin

(2010) Walter Richter et al.   Innate Immunity

Characterization of liposomes formed by lipopolysaccharides from Burkholderia cenocepacia, Burkholderia multivorans and Agrobacterium tumefaciens: from the molecular structure to the aggregate architecture

(2010) Gerardino D'Errico et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Identification of Undecaprenyl Phosphate-β-d-Galactosamine inFrancisella novicidaand Its Function in Lipid A Modification†

(2009) Xiaoyuan Wang et al.   BIOCHEMISTRY

Evidence of a Specific Interaction between New Synthetic Antisepsis Agents and CD14

(2009) Matteo Piazza et al.   BIOCHEMISTRY

The potential use of toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents

(2009) Amani Makkouk et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

(2009) Nuša Resman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation

(2009) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis and Structure of theBurkholderia cenocepaciaK56-2 Lipopolysaccharide Core Oligosaccharide

(2009) Ximena Ortega et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural analysis of the lipid A isolated fromHafnia alvei32 and PCM 1192 lipopolysaccharides

(2009) Jolanta Lukasiewicz et al.   JOURNAL OF LIPID RESEARCH

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

(2009) L. A. J. O'Neill et al.   PHARMACOLOGICAL REVIEWS

Mesoscopic and microstructural characterization of liposomes formed by the lipooligosaccharide from Salmonella minnesota strain 595 (Re mutant)

(2009) Gerardino D’Errico et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mechanical properties of interacting lipopolysaccharide membranes from bacteria mutants studied by specular and off-specular neutron scattering

(2009) Emanuel Schneck et al.   PHYSICAL REVIEW E

Interactions of a designed peptide with lipopolysaccharide: Bound conformation and anti-endotoxic activity

(2008) Anirban Bhunia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NMR spectral mapping of Lipid A molecular patterns affected by interaction with the innate immune receptor CD14

(2008) Seth Albright et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interaction of Lipopolysaccharide and Phospholipid in Mixed Membranes: Solid-State 31P-NMR Spectroscopic and Microscopic Investigations

(2008) Kaoru Nomura et al.   BIOPHYSICAL JOURNAL

Characterization of a novel lipid A structure isolated from Azospirillum lipoferum lipopolysaccharide

(2008) Adam Choma et al.   CARBOHYDRATE RESEARCH

Lipopolysaccharide structures from Agrobacterium and Rhizobiaceae species

(2008) Cristina De Castro et al.   CARBOHYDRATE RESEARCH

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Acylation and Phosphorylation Pattern of Lipid A fromXanthomonas Campestris Strongly Influence its Ability to Trigger the Innate Immune Response in Arabidopsis

(2008) Alba Silipo et al.   CHEMBIOCHEM

Structures of TLR–ligand complexes

(2008) Mi Sun Jin et al.   CURRENT OPINION IN IMMUNOLOGY

Synthetic TLR4-active Glycolipids as Vaccine Adjuvants and Stand-alone Immunotherapeutics

(2008) David Johnson   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure of a novel lipid A obtained from the lipopolysaccharide of Caulobacter crescentus

(2008) John Smit et al.   Innate Immunity

Acyl Chain Specificity of the Acyltransferases LpxA and LpxD and Substrate Availability Contribute to Lipid A Fatty Acid Heterogeneity in Porphyromonas gingivalis

(2008) B. W. Bainbridge et al.   JOURNAL OF BACTERIOLOGY

Glucosamine Found as a Substituent of Both Phosphate Groups in Bordetella Lipid A Backbones: Role of a BvgAS-Activated ArnT Ortholog

(2008) N. Marr et al.   JOURNAL OF BACTERIOLOGY

The Fine Structure ofNeisseria meningitidisLipooligosaccharide from the M986 Strain and Three of Its Variants

(2008) Chao-Ming Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity

(2008) Duangjit Kanistanon et al.   PLoS Pathogens

Structural characterizations of lipids A by MS/MS of doubly charged ions on a hybrid linear ion trap/orbitrap mass spectrometer

(2007) Alba Silipo et al.   JOURNAL OF MASS SPECTROMETRY