Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

NK cells and type 1 innate lymphoid cells: partners in host defense

(2016) Hergen Spits et al.   NATURE IMMUNOLOGY

Long-term immunogenicity and safety of an investigational herpes zoster subunit vaccine in older adults

(2016) Roman Chlibek et al.   VACCINE

The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for TH1 Induction

(2016) Natasha Dubois Cauwelaert et al.   PLoS One

Central Role of CD169+ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01

(2016) Sophie Detienne et al.   Scientific Reports

Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

(2015) Helder I. Nakaya et al.   IMMUNITY

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

(2015) Robyn Marty-Roix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Not Just a Sum? Identifying Different Types of Interplay between Constituents in Combined Interventions

(2015) Katrijn Van Deun et al.   PLoS One

The role of lymph node sinus macrophages in host defense

(2014) Mirela Kuka et al.   Annals of the New York Academy of Sciences

Memory-T-Cell-Derived Interferon-γ Instructs Potent Innate Cell Activation for Protective Immunity

(2014) Saïdi M’Homa Soudja et al.   IMMUNITY

Homeostasis and Effector Function of Lymphopenia-Induced "Memory-Like" T Cells in Constitutively T Cell-Depleted Mice

(2014) D. Voehringer et al.   JOURNAL OF IMMUNOLOGY

Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells

(2014) Arnaud M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

In Vivo IFN-γ Secretion by NK Cells in Response to Salmonella Typhimurium Requires NLRC4 Inflammasomes

(2014) Andreas Kupz et al.   PLoS One

Transgenic Parasites Stably Expressing Full-Length Plasmodium falciparum Circumsporozoite Protein as a Model for Vaccine Down-Selection in Mice Using Sterile Protection as an Endpoint

(2013) Michael D. Porter et al.   Clinical and Vaccine Immunology

Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8+ T Cell Responses in the Lymph Node

(2013) Wolfgang Kastenmüller et al.   IMMUNITY

Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines

(2013) Gerlinde Obermoser et al.   IMMUNITY

Analysis of T Cell Responses during Active Varicella-Zoster Virus Reactivation in Human Ganglia

(2013) M. Steain et al.   JOURNAL OF VIROLOGY

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

(2012) Wolfgang Kastenmüller et al.   CELL

NK Cell-Derived Interferon-γ Orchestrates Cellular Dynamics and the Differentiation of Monocytes into Dendritic Cells at the Site of Infection

(2012) Romina S. Goldszmid et al.   IMMUNITY

NK Cells Regulate CD8+ T Cell Priming and Dendritic Cell Migration during Influenza A Infection by IFN-  and Perforin-Dependent Mechanisms

(2012) M. Q. Ge et al.   JOURNAL OF IMMUNOLOGY

Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice

(2012) Najoua Dendouga et al.   VACCINE

Improved CD4+ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: A randomized trial

(2012) Isabel Leroux-Roels et al.   VACCINE

An Adjuvanted Polyprotein HIV-1 Vaccine Induces Polyfunctional Cross-Reactive CD4+ T Cell Responses in Seronegative Volunteers

(2011) Eva Van Braeckel et al.   CLINICAL INFECTIOUS DISEASES

Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

(2011) Govind Ragupathi et al.   Expert Review of Vaccines

Early Patterns of Gene Expression Correlate With the Humoral Immune Response to Influenza Vaccination in Humans

(2011) Kristine L. Bucasas et al.   JOURNAL OF INFECTIOUS DISEASES

Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor

(2011) E. Narni-Mancinelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination adjuvants: the next generation of adjuvants?

(2010) George Mutwiri et al.   Expert Review of Vaccines

Cross-Talk between T Cells and NK Cells Generates Rapid Effector Responses to Plasmodium falciparum-Infected Erythrocytes

(2010) A. Horowitz et al.   JOURNAL OF IMMUNOLOGY

NK Cells as Effectors of Acquired Immune Responses: Effector CD4+ T Cell-Dependent Activation of NK Cells Following Vaccination

(2010) A. Horowitz et al.   JOURNAL OF IMMUNOLOGY

Drug delivery to the lymphatic system: importance in future cancer diagnosis and therapies

(2009) Yumei Xie et al.   Expert Opinion on Drug Delivery

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular and cellular signatures of human vaccine adjuvants

(2008) F. Mosca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen

(2008) Pascal Mettens et al.   VACCINE