Design and synthesis of galactose-6-OH-modified α-galactosyl ceramide analogues with Th2-biased immune responses

RCAI-61 and related 6′-modified analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce interferon-γ in vivo

(2013) Takuya Tashiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of Hydroxylated Analogues of α-Galactosyl Ceramide (KRN7000) with Varying Stereochemistry

(2013) Ratnnadeep C. Sawant et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Biological Evaluation of α-Galactosylceramide Analogues with Heteroaromatic Rings and Varying Positions of a Phenyl Group in the Sphingosine Backbone

(2013) Yongju Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amide Analogues of CD1d Agonists Modulate iNKT-Cell-Mediated Cytokine Production

(2012) Justyna Wojno et al.   ACS Chemical Biology

RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines

(2012) Takuya Tashiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides

(2012) Peter J. Jervis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

(2012) Peter J. Jervis et al.   CARBOHYDRATE RESEARCH

Concise synthesis of α-galactosyl ceramide from d-galactosyl iodide and d-lyxose

(2012) Yu-Fen Yen et al.   CARBOHYDRATE RESEARCH

Synthesis and Evaluation of Acyl-Chain- and Galactose-6′′-Modified Analogues of α-GalCer for NKT Cell Activation

(2012) Ming-Han Hsieh et al.   CHEMBIOCHEM

3-Fluoro- and 3,3-Difluoro-3,4-dideoxy-KRN7000 Analogues as New Potent Immunostimulator Agents: Total Synthesis and Biological Evaluation in Human Invariant Natural Killer T Cells and Mice

(2012) Julie Hunault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

(2011) Sandrine Aspeslagh et al.   EMBO JOURNAL

Iminosugar Analogues of Phosphatidyl Inositol as Potential Inhibitors of Protein Kinase B (Akt)

(2011) Alexandre Orsato et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Divergent synthetic approach to 6′′-modified α-GalCer analogues

(2011) Nora Pauwels et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The stimulating adventure of KRN 7000

(2011) Aline Banchet-Cadeddu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy

(2011) T.-N. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

One-Pot Syntheses of Immunostimulatory Glycolipids

(2010) Matthew Schombs et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of a Versatile Building Block for the Preparation of 6-N-Derivatized α-Galactosyl Ceramides: Rapid Access to Biologically Active Glycolipids

(2010) Peter J. Jervis et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and evaluation of 3″- and 4″-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000

(2009) Ravinder Raju et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Focus on the Controversial Activation of Human iNKT Cells by 4-Deoxy Analogue of KRN7000

(2009) Vivien Lacône et al.   JOURNAL OF MEDICINAL CHEMISTRY

RCAI-17, 22, 24–26, 29, 31, 34–36, 38–40, and 88, the analogs of KRN7000 with a sulfonamide linkage: Their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines

(2008) Takuya Tashiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preparation of partially benzylated mono-, di-, and trisaccharides by selective cleavage of the β-fructofuranosidic linkage in fully benzylated sucrose and sucrose-related oligosaccharides under acidic conditions

(2008) Takashi Yamanoi et al.   CARBOHYDRATE RESEARCH

Structural establishment of polygalatenosides A and B by total synthesis

(2008) Chih-Ming Huang et al.   TETRAHEDRON LETTERS

RCAI-61, the 6′-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-γ in vivo

(2008) Takuya Tashiro et al.   TETRAHEDRON LETTERS

Glycolipids as immunostimulating agents

(2007) Douglass Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

RCAI-8, 9, 18, 19, and 49–52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines

(2007) Ken-ichi Fuhshuku et al.   BIOORGANIC & MEDICINAL CHEMISTRY