MeCP2: The Genetic Driver of Rett Syndrome Epigenetics

Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with bone disease severity in Rett syndrome

(2020) Carla Caffarelli et al.   BMC Medical Genetics

Rett syndrome-causing mutations compromise MeCP2-mediated liquid–liquid phase separation of chromatin

(2020) Liang Wang et al.   CELL RESEARCH

MECP2 mutation spectrum and its clinical characteristics in a Chinese cohort

(2020) Yongxin Wen et al.   CLINICAL GENETICS

MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders

(2020) Angelisa Frasca et al.   EMBO Molecular Medicine

Pharmacological readthrough of R294X Mecp2 in a novel mouse model of Rett Syndrome

(2020) Jonathan K Merritt et al.   HUMAN MOLECULAR GENETICS

Metabolism and the Epigenome: A Dynamic Relationship

(2020) Spencer A. Haws et al.   TRENDS IN BIOCHEMICAL SCIENCES

Detection of Rare Methyl-CpG Binding Protein 2 Gene Missense Mutations in Patients With Schizophrenia

(2020) Chia-Hsiang Chen et al.   Frontiers in Genetics

Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder

(2020) Sang Hoon Yoon et al.   Journal of Clinical Medicine

Regulation, Diversity and Function of MECP2 Exon and 3’UTR Isoforms

(2020) Deivid Carvalho Rodrigues et al.   HUMAN MOLECULAR GENETICS

MeCP2 links heterochromatin condensates and neurodevelopmental disease

(2020) Charles H. Li et al.   NATURE

In Vivo Repair of a Protein Underlying a Neurological Disorder by Programmable RNA Editing

(2020) John R. Sinnamon et al.   Cell Reports

Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing

(2020) Kashyap Chhatbar et al.   PLoS Genetics

The MeCP2E1/E2-BDNF-miR132 Homeostasis Regulatory Network Is Region-Dependent in the Human Brain and Is Impaired in Rett Syndrome Patients

(2020) Shervin Pejhan et al.   Frontiers in Cell and Developmental Biology

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus

(2020) David V. C. Brito et al.   Molecular Brain

MeCP2 and Major Satellite Forward RNA Cooperate for Pericentric Heterochromatin Organization

(2020) Salvatore Fioriniello et al.   Stem Cell Reports

Post-translational modification control of RNA-binding protein hnRNPK function

(2019) Yongjie Xu et al.   Open Biology

Regression in Rett syndrome: Developmental pathways to its onset

(2019) Christa Einspieler et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Treating Rett syndrome: from mouse models to human therapies

(2019) Neeti Vashi et al.   MAMMALIAN GENOME

DNA Methylation Contributes to the Differential Expression Levels of Mecp2 in Male Mice Neurons and Astrocytes

(2019) Vichithra R.B. Liyanage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senescence Phenomena and Metabolic Alteration in Mesenchymal Stromal Cells from a Mouse Model of Rett Syndrome

(2019) Tiziana Squillaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation

(2019) Maiwen Caudron-Herger et al.   MOLECULAR CELL

The importance of long non-coding RNAs in neuropsychiatric disorders

(2019) Ebrahim Hosseini et al.   MOLECULAR ASPECTS OF MEDICINE

Brain-enriched microRNAs circulating in plasma as novel biomarkers for Rett syndrome

(2019) Kira Sheinerman et al.   PLoS One

Long noncoding RNA NEAT1 mediates neuronal histone methylation and age-related memory impairment

(2019) Anderson A. Butler et al.   Science Signaling

Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice

(2019) Xin Tang et al.   Science Translational Medicine

The diverse roles of DNA methylation in mammalian development and disease

(2019) Maxim V. C. Greenberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels

(2019) Xiaopei Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATRX Contributes to MeCP2-Mediated Pericentric Heterochromatin Organization during Neural Differentiation

(2019) Domenico Marano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

(2019) Alexia Martínez de Paz et al.   Epigenetics & Chromatin

The distinct methylation landscape of maturing neurons and its role in Rett syndrome pathogenesis

(2019) Laura A Lavery et al.   CURRENT OPINION IN NEUROBIOLOGY

Genomic insights into MeCP2 function: A role for the maintenance of chromatin architecture

(2019) Daniel R Connolly et al.   CURRENT OPINION IN NEUROBIOLOGY

DNA methylation directs microRNA biogenesis in mammalian cells

(2019) Ohad Glaich et al.   Nature Communications

MeCP2_e2 partially compensates for lack of MeCP2_e1: A male case of Rett syndrome

(2019) Ryo Takeguchi et al.   Molecular Genetics & Genomic Medicine

Current clinical evidence does not support a link between TBL1XR1 and Rett syndrome: Description of one patient with Rett features and a novel mutation in TBL1XR1 , and a review of TBL1XR1 phenotypes

(2018) Manar Zaghlula et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Intestinal Candida parapsilosis isolates from Rett syndrome subjects bear potential virulent traits and capacity to persist within the host

(2018) Francesco Strati et al.   BMC GASTROENTEROLOGY

The Effect of Mecp2 on Heart Failure

(2018) Chunli Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MeCP2 AT-Hook1 mutations in patients with intellectual disability and/or schizophrenia disrupt DNA binding and chromatin compaction in vitro

(2018) Taimoor I. Sheikh et al.   HUMAN MUTATION

RGG/RG Motif Regions in RNA Binding and Phase Separation

(2018) P. Andrew Chong et al.   JOURNAL OF MOLECULAR BIOLOGY

A user's guide to the ambiguous word 'epigenetics'

(2018) John M. Greally   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activity-dependent aberrations in gene expression and alternative splicing in a mouse model of Rett syndrome

(2018) Sivan Osenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of MeCP2 in neurological disorders: current status and future perspectives

(2018) Juan Ausió   Epigenomics

Precise temporal regulation of alternative splicing during neural development

(2018) Sebastien M. Weyn-Vanhentenryck et al.   Nature Communications

Rett syndrome: a neurological disorder with metabolic components

(2018) Stephanie M. Kyle et al.   Open Biology

Mouse models as a tool for discovering new neurological diseases

(2018) Qiumin Tan et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Tsix–Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function

(2018) Lieselot L. G. Carrette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2

(2018) Matthew J. Lyst et al.   Cell Reports

Haploinsufficiency of NCOR1 associated with autism spectrum disorder, scoliosis, and abnormal palatogenesis

(2018) Yuri Sakaguchi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Towards a better diagnosis and treatment of Rett syndrome: a model synaptic disorder

(2018) Abhishek Banerjee et al.   BRAIN

The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest

(2018) Jakob Trendel et al.   CELL

FOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus

(2018) Stefan C. Weise et al.   MOLECULAR NEUROBIOLOGY

Impaired Visual Search in Children with Rett Syndrome

(2018) Susan A. Rose et al.   PEDIATRIC NEUROLOGY

MECP2 Mutation Interrupts Nucleolin–mTOR–P70S6K Signaling in Rett Syndrome Patients

(2018) Carl O. Olson et al.   Frontiers in Genetics

MeCP2 interacts with chromosomal microRNAs in brain

(2017) Abdul Waheed Khan et al.   Epigenetics

MeCP2_E1 N-terminal modifications affect its degradation rate and are disrupted by the Ala2Val Rett mutation

(2017) Taimoor I Sheikh et al.   HUMAN MOLECULAR GENETICS

RettBASE: Rett syndrome database update

(2017) Rahul Krishnaraj et al.   HUMAN MUTATION

Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome–like phenotypes

(2017) Janine M. Lamonica et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Basis of MeCP2 Distribution on Non-CpG Methylated and Hydroxymethylated DNA

(2017) M. Jeannette Sperlazza et al.   JOURNAL OF MOLECULAR BIOLOGY

Radically truncated MeCP2 rescues Rett syndrome-like neurological defects

(2017) Rebekah Tillotson et al.   NATURE

NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

(2017) Li Jiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders

(2017) Lieselot L. G. Carrette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression

(2017) Smitha Sripathy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the MeCP2–TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders

(2017) Valdeko Kruusvee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant

(2017) Aurore Curie et al.   PSYCHIATRIC GENETICS

Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

(2017) Justin J. -L. Wong et al.   Nature Communications

NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

(2017) Li Jiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock

(2017) Lucia Mendoza-Viveros et al.   Cell Reports

MeCP2 mutations: progress towards understanding and treating Rett syndrome

(2017) Ruth R. Shah et al.   Genome Medicine

Binding Analysis of Methyl-CpG Binding Domain of MeCP2 and Rett Syndrome Mutations

(2016) Ye Yang et al.   ACS Chemical Biology

Pervasive lncRNA binding by epigenetic modifying complexes — The challenges ahead

(2016) Juan G. Betancur   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The new (dis)order in RNA regulation

(2016) Aino I. Järvelin et al.   Cell Communication and Signaling

High-Resolution Mapping of RNA-Binding Regions in the Nuclear Proteome of Embryonic Stem Cells

(2016) Chongsheng He et al.   MOLECULAR CELL

Comprehensive Identification of RNA-Binding Domains in Human Cells

(2016) Alfredo Castello et al.   MOLECULAR CELL

Unexpected cellular players in Rett syndrome pathology

(2016) James C. Cronk et al.   NEUROBIOLOGY OF DISEASE

Rett syndrome – biological pathways leading from MECP2 to disorder phenotypes

(2016) Friederike Ehrhart et al.   Orphanet Journal of Rare Diseases

A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation

(2016) Derek Lessing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Determinants of Cancer

(2016) Stephen B. Baylin et al.   Cold Spring Harbor Perspectives in Biology

Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

(2016) Noriyuki Kishi et al.   Nature Communications

MECP2 Is Post-transcriptionally Regulated during Human Neurodevelopment by Combinatorial Action of RNA-Binding Proteins and miRNAs

(2016) Deivid C. Rodrigues et al.   Cell Reports

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome

(2016) Ronghui Li et al.   PLoS Genetics

MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction

(2016) Juan Ausió   Clinical Epigenetics

Altered gut microbiota in Rett syndrome

(2016) Francesco Strati et al.   Microbiome

From Function to Phenotype: Impaired DNA Binding and Clustering Correlates with Clinical Severity in Males with Missense Mutations in MECP2

(2016) Taimoor I. Sheikh et al.   Scientific Reports

Impact of Rett Syndrome Mutations on MeCP2 MBD Stability

(2015) Tugba G. Kucukkal et al.   BIOCHEMISTRY

Evf2lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling

(2015) Ivelisse Cajigas et al.   DEVELOPMENT

Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse

(2015) Yoshiki Tsuchiya et al.   GENES TO CELLS

A Novel Mutation p.A59P in N-Terminal Domain of Methyl-CpG–Binding Protein 2 Confers Phenotypic Variability in 3 Cases of Tunisian Rett Patients

(2015) Marwa Kharrat et al.   JOURNAL OF CHILD NEUROLOGY

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

(2015) Harrison W. Gabel et al.   NATURE

Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT

(2015) Quan Li et al.   NEUROBIOLOGY OF DISEASE

Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2

(2015) Benyam Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The extended AT-hook is a novel RNA binding motif

(2015) Michael Filarsky et al.   RNA Biology

A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2′-dC upon inhibition of ribonucleotide reductase

(2015) Alissa Minkovsky et al.   Epigenetics & Chromatin

MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy

(2015) M. Neupane et al.   Cancer Discovery

miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes

(2015) Keita Tsujimura et al.   Cell Reports

The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation

(2015) Fan Yang et al.   GENOME BIOLOGY

Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes

(2015) Alexia Martínez de Paz et al.   PLoS One

MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex

(2014) Tian-Lin Cheng et al.   DEVELOPMENTAL CELL

Methyl-CpG-binding protein 2(MECP2) mutation type is associated with disease severity in Rett syndrome

(2014) Vishnu Anand Cuddapah et al.   JOURNAL OF MEDICAL GENETICS

MeCP2 deficiency is associated with reduced levels of tubulin acetylation and can be restored using HDAC6 inhibitors

(2014) W. A. Gold et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability

(2014) S E McCarthy et al.   MOLECULAR PSYCHIATRY

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The structure, function and evolution of proteins that bind DNA and RNA

(2014) William H. Hudson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rett Syndrome and MeCP2

(2014) Vichithra R. B. Liyanage et al.   NEUROMOLECULAR MEDICINE

The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease

(2014) T. C. Roberts et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements

(2014) Carl O. Olson et al.   PLoS One

MeCP2 enforces Foxp3 expression to promote regulatory T cells’ resilience to inflammation

(2014) Chaoran Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2: the long trip from a chromatin protein to neurological disorders

(2014) Juan Ausió et al.   TRENDS IN MOLECULAR MEDICINE

MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?

(2014) Elisa Bellini et al.   Frontiers in Cellular Neuroscience

Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition

(2014) R. Marmorstein et al.   Cold Spring Harbor Perspectives in Biology

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Microprocessor Activity Controls Differential miRNA Biogenesis In Vivo

(2014) Thomas Conrad et al.   Cell Reports

Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice

(2014) Laura Dean Heckman et al.   eLife

Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain

(2014) Lu Wen et al.   GENOME BIOLOGY

The MicroRNA Biology of the Mammalian Nucleus

(2014) Thomas C Roberts   Molecular Therapy-Nucleic Acids

Increased Binding of Stroke-Induced Long Non-Coding RNAs to the Transcriptional Corepressors Sin3A and coREST

(2013) Ashutosh Dharap et al.   ASN Neuro

An AT-Hook Domain in MeCP2 Determines the Clinical Course of Rett Syndrome and Related Disorders

(2013) Steven Andrew Baker et al.   CELL

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

(2013) Alika K Maunakea et al.   CELL RESEARCH

Evf2 (Dlx6as) lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes

(2013) E. G. Berghoff et al.   DEVELOPMENT

Novel alterations in the epigenetic signature of MeCP2-targeted promoters in lymphocytes of Rett syndrome patients

(2013) Tobias Lilja et al.   Epigenetics

Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats

(2013) Jing Xue et al.   Epigenetics

Genes Related to Mitochondrial Functions, Protein Degradation, and Chromatin Folding Are Differentially Expressed in Lymphomonocytes of Rett Syndrome Patients

(2013) Alessandra Pecorelli et al.   MEDIATORS OF INFLAMMATION

Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation

(2013) Ailan Guo et al.   MOLECULAR & CELLULAR PROTEOMICS

Defining the RGG/RG Motif

(2013) Palaniraja Thandapani et al.   MOLECULAR CELL

Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR

(2013) Daniel H. Ebert et al.   NATURE

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

(2013) Matthew J Lyst et al.   NATURE NEUROSCIENCE

Chromatin regulators of neural development

(2013) K. Tyssowski et al.   NEUROSCIENCE

Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice

(2013) S. Subbanna et al.   NEUROSCIENCE

Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain

(2013) D. P. Stuss et al.   NUCLEIC ACIDS RESEARCH

A synonymous change, p.Gly16Gly in MECP2 Exon 1, causes a cryptic splice event in a Rett Syndrome patient

(2013) Taimoor I Sheikh et al.   Orphanet Journal of Rare Diseases

Chromatin context and ncRNA highlight targets of MeCP2 in brain

(2013) Scott S Maxwell et al.   RNA Biology

Dysregulation of the long non-coding RNA transcriptome in a Rett syndrome mouse model

(2013) Paolo Petazzi et al.   RNA Biology

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Phosphorylation of DGCR8 Increases Its Intracellular Stability and Induces a Progrowth miRNA Profile

(2013) Kristina M. Herbert et al.   Cell Reports

New advances of DNA methylation and histone modifications in rheumatoid arthritis, with special emphasis on MeCP2

(2012) Cheng-gui Miao et al.   CELLULAR SIGNALLING

SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression

(2012) Loredana Zocchi et al.   Epigenetics

MeCP2 deficiency is associated with impaired microtubule stability

(2012) Chloé Delépine et al.   FEBS LETTERS

Methyl CpG-binding Protein Isoform MeCP2_e2 Is Dispensable for Rett Syndrome Phenotypes but Essential for Embryo Viability and Placenta Development

(2012) Masayuki Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gastrointestinal and Nutritional Problems Occur Frequently Throughout Life in Girls and Women With Rett Syndrome

(2012) Kathleen J. Motil et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Phosphorylation of Distinct Sites in MeCP2 Modifies Cofactor Associations and the Dynamics of Transcriptional Regulation

(2012) M. L. Gonzales et al.   MOLECULAR AND CELLULAR BIOLOGY

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

(2012) Tarang Khare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes

(2012) Robby M. Zachariah et al.   PLoS One

Coil-to-helix transitions in intrinsically disordered methyl CpG binding protein 2 and its isolated domains

(2012) Kristopher C. Hite et al.   PROTEIN SCIENCE

Mutations in MECP2 exon 1 in classical rett patients disrupt MECP2_e1 transcription, but not transcription of MECP2_e2

(2011) Peter J. Gianakopoulos et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

MeCP2 Rett mutations affect large scale chromatin organization

(2011) Noopur Agarwal et al.   HUMAN MOLECULAR GENETICS

Arginine methylation of RNA-binding proteins regulates cell function and differentiation

(2011) Ernest Blackwell et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression

(2011) Rikako Sanuki et al.   NATURE NEUROSCIENCE

MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

(2011) Anita A. Thambirajah et al.   NUCLEIC ACIDS RESEARCH

Unique Physical Properties and Interactions of the Domains of Methylated DNA Binding Protein 2

(2010) Rajarshi P. Ghosh et al.   BIOCHEMISTRY

A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing

(2010) Steven W. Long et al.   BIOSCIENCE REPORTS

Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment

(2010) Angela J McArthur et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome

(2010) H. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin proteasome system in neuropathology

(2009) Norman L. Lehman   ACTA NEUROPATHOLOGICA

Novel exon 1 mutations in MECP2 implicate isoform MeCP2_e1 in classical Rett syndrome

(2009) Carol J. Saunders et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

MeCP2 post-translational regulation through PEST domains: two novel hypotheses

(2009) Anita A. Thambirajah et al.   BIOESSAYS

Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome

(2009) R.D. O'Connor et al.   BONE

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Updating the profile of C-terminal MECP2 deletions in Rett syndrome

(2009) A. Bebbington et al.   JOURNAL OF MEDICAL GENETICS

A short motif in Drosophila SECIS Binding Protein 2 provides differential binding affinity to SECIS RNA hairpins

(2009) Akiko Takeuchi et al.   NUCLEIC ACIDS RESEARCH

Rett Syndrome-causing Mutations in Human MeCP2 Result in Diverse Structural Changes That Impact Folding and DNA Interactions

(2008) Rajarshi P. Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG

(2008) Kok Lian Ho et al.   MOLECULAR CELL

The first missense mutation causing Rett syndrome specifically affecting the MeCP2_e1 isoform

(2008) Yann Fichou et al.   NEUROGENETICS

Specific mutations in Methyl-CpG-Binding Protein 2 confer different severity in Rett syndrome

(2008) J. L. Neul et al.   NEUROLOGY

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE