MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity

(2017) Katrina V. Good et al.   Epigenetics

MeCP2_E1 N-terminal modifications affect its degradation rate and are disrupted by the Ala2Val Rett mutation

(2017) Taimoor I Sheikh et al.   HUMAN MOLECULAR GENETICS

EB1 and EB3 regulate microtubule minus end organization and Golgi morphology

(2017) Chao Yang et al.   JOURNAL OF CELL BIOLOGY

Structure of the MeCP2–TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders

(2017) Valdeko Kruusvee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain

(2017) Sabine Lagger et al.   PLoS Genetics

The Crucial Role of DNA Methylation and MeCP2 in Neuronal Function

(2017) et al.   Genes

Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations

(2017) Nicholas I. Brodie et al.   Science Advances

The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site

(2017) Rafael Claveria-Gimeno et al.   Scientific Reports

Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications

(2016) Alaji Bah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease

(2016) Isidro Ferrer et al.   Frontiers in Aging Neuroscience

PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges

(2016) Libin Liu et al.   eLife

Using combined evidence from replicates to evaluate ChIP-seq peaks

(2015) Vahid Jalili et al.   BIOINFORMATICS

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization

(2015) Guangchuang Yu et al.   BIOINFORMATICS

Defects DuringMecp2Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms

(2015) Francesco Bedogni et al.   CEREBRAL CORTEX

Karyopherin α 3 and Karyopherin α 4 Proteins Mediate the Nuclear Import of Methyl-CpG Binding Protein 2

(2015) Steven Andrew Baker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Borna Disease Virus Phosphoprotein Modulates Epigenetic Signaling in Neurons To Control Viral Replication

(2015) Emilie M. Bonnaud et al.   JOURNAL OF VIROLOGY

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

(2015) Harrison W. Gabel et al.   NATURE

From the genetic architecture to synaptic plasticity in autism spectrum disorder

(2015) Thomas Bourgeron   NATURE REVIEWS NEUROSCIENCE

miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes

(2015) Keita Tsujimura et al.   Cell Reports

Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes

(2015) Alexia Martínez de Paz et al.   PLoS One

Replication-dependent histone genes are actively transcribed in differentiating and aging retinal neurons

(2014) Abdul Rouf Banday et al.   CELL CYCLE

Methyl-CpG Binding Protein 2 (MeCP2) Localizes at the Centrosome and Is Required for Proper Mitotic Spindle Organization

(2014) Anna Bergo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

deepTools: a flexible platform for exploring deep-sequencing data

(2014) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements

(2014) Carl O. Olson et al.   PLoS One

MeCP2: the long trip from a chromatin protein to neurological disorders

(2014) Juan Ausió et al.   TRENDS IN MOLECULAR MEDICINE

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

(2013) Alika K Maunakea et al.   CELL RESEARCH

Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome

(2013) Dag H. Yasui et al.   HUMAN MOLECULAR GENETICS

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

MeCP2 deficiency is associated with impaired microtubule stability

(2012) Chloé Delépine et al.   FEBS LETTERS

Methyl CpG-binding Protein Isoform MeCP2_e2 Is Dispensable for Rett Syndrome Phenotypes but Essential for Embryo Viability and Placenta Development

(2012) Masayuki Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements

(2012) A. Y. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coil-to-helix transitions in intrinsically disordered methyl CpG binding protein 2 and its isolated domains

(2012) Kristopher C. Hite et al.   PROTEIN SCIENCE

A Combination of H2A.Z and H4 Acetylation Recruits Brd2 to Chromatin during Transcriptional Activation

(2012) Ryan Draker et al.   PLoS Genetics

Intrinsically disordered proteins: regulation and disease

(2011) M Madan Babu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes

(2011) Bredford Kerr et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

The nucleoskeleton as a genome-associated dynamic 'network of networks'

(2011) Dan N. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation

(2011) Malaika K. Singleton et al.   NEUROBIOLOGY OF DISEASE

RSAT peak-motifs: motif analysis in full-size ChIP-seq datasets

(2011) Morgane Thomas-Chollier et al.   NUCLEIC ACIDS RESEARCH

Context-dependent resistance to proteolysis of intrinsically disordered proteins

(2011) Marcin J. Suskiewicz et al.   PROTEIN SCIENCE

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes

(2010) Chantelle F. Sephton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites

(2010) R. P. Ghosh et al.   MOLECULAR AND CELLULAR BIOLOGY

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

(2010) Peter J. Skene et al.   MOLECULAR CELL

Novel exon 1 mutations in MECP2 implicate isoform MeCP2_e1 in classical Rett syndrome

(2009) Carol J. Saunders et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data

(2009) Chongzhi Zang et al.   BIOINFORMATICS

The Latency-Associated Nuclear Antigen Interacts with MeCP2 and Nucleosomes through Separate Domains

(2009) S. Matsumura et al.   JOURNAL OF VIROLOGY

Epigenetic regulation of TTF-I-mediated promoter–terminator interactions of rRNA genes

(2008) Attila Németh et al.   EMBO JOURNAL

The first missense mutation causing Rett syndrome specifically affecting the MeCP2_e1 isoform

(2008) Yann Fichou et al.   NEUROGENETICS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH