MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction

DNA Methylation and Its Implications and Accessibility for Neuropsychiatric Therapeutics

(2015) Jeremy J. Day et al.   Annual Review of Pharmacology and Toxicology

Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges

(2015) Xavier Bofill-De Ros et al.   BMC GENOMICS

Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart FailureNovelty and Significance

(2015) Sandra C. Mayer et al.   CIRCULATION RESEARCH

MECP2 disorders: from the clinic to mice and back

(2015) Laura Marie Lombardi et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of DNA Methylation in the Nucleus Accumbens in Incubation of Cocaine Craving

(2015) R. Massart et al.   JOURNAL OF NEUROSCIENCE

The role of childhood maltreatment in the altered trait and global expression of personality in cocaine addiction

(2015) Lisa K. Brents et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Addiction et régulations épigénétiques

(2015) Jean Zwiller   M S-MEDECINE SCIENCES

Structural Mechanisms of Nucleosome Recognition by Linker Histones

(2015) Bing-Rui Zhou et al.   MOLECULAR CELL

MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA-132 in rats with depression

(2015) MEILEI SU et al.   Molecular Medicine Reports

First robust genetic links to depression emerge

(2015) Heidi Ledford   NATURE

Genetics: No more addictive personality

(2015) Maia Szalavitz   NATURE

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

(2015) Harrison W. Gabel et al.   NATURE

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

(2015) Huimei Yu et al.   NATURE NEUROSCIENCE

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

(2015) Jian Feng et al.   NATURE NEUROSCIENCE

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity

(2015) Ian Maze et al.   NEURON

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

(2015) Lin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis

(2015) Hui Dong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Histone Variants and Epigenetics

(2015) Steven Henikoff et al.   Cold Spring Harbor Perspectives in Biology

MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy

(2015) M. Neupane et al.   Cancer Discovery

At the frontier of epigenetics of brain sex differences

(2015) Margaret M. McCarthy et al.   Frontiers in Behavioral Neuroscience

Circulating microRNA-144-5p is associated with depressive disorders

(2015) Xiao Wang et al.   Clinical Epigenetics

Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes

(2015) Alexia Martínez de Paz et al.   PLoS One

SnapShot: Histone Modifications

(2014) He Huang et al.   CELL

Replication-dependent histone genes are actively transcribed in differentiating and aging retinal neurons

(2014) Abdul Rouf Banday et al.   CELL CYCLE

Early-Life Stress Reduces DNA Methylation of thePomcGene in Male Mice

(2014) Yonghe Wu et al.   ENDOCRINOLOGY

dBigH1, a second histone H1 inDrosophila, and the consequences for histone fold nomenclature

(2014) Rodrigo González-Romero et al.   Epigenetics

Differential regulation of MeCP2 and PP1 in passive or voluntary administration of cocaine or food

(2014) Sarah Pol Bodetto et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

RING Finger Protein 4 (RNF4) Derepresses Gene Expression from DNA Methylation

(2014) Yu Wang   JOURNAL OF BIOLOGICAL CHEMISTRY

A Distinct Switch in Interactions of the Histone H4 Tail Domain upon Salt-dependent Folding of Nucleosome Arrays

(2014) Sharon Pepenella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MeCP2 Phosphorylation Limits Psychostimulant-Induced Behavioral and Neuronal Plasticity

(2014) J. V. Deng et al.   JOURNAL OF NEUROSCIENCE

Histone H2A.Z subunit exchange controls consolidation of recent and remote memory

(2014) Iva B. Zovkic et al.   NATURE

Every amino acid matters: essential contributions of histone variants to mammalian development and disease

(2014) Ian Maze et al.   NATURE REVIEWS GENETICS

MeCP2: the long trip from a chromatin protein to neurological disorders

(2014) Juan Ausió et al.   TRENDS IN MOLECULAR MEDICINE

MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?

(2014) Elisa Bellini et al.   Frontiers in Cellular Neuroscience

The effects of perinatal testosterone exposure on the DNA methylome of the mouse brain are late-emerging

(2014) Negar M Ghahramani et al.   Biology of Sex Differences

Differential methylation of the micro-RNA 7b gene targets postnatal maturation of murine neuronalMecp2gene expression

(2013) Yongjun Chen et al.   Developmental Neurobiology

Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p

(2013) K. Han et al.   GENES & DEVELOPMENT

Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes

(2013) Emmette R. Hutchison et al.   GLIA

Shaping synaptic plasticity: The role of activity-mediated epigenetic regulation on gene transcription

(2013) Javier Cortés-Mendoza et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Epigenetic Mechanisms may Underlie the Aetiology of Sex Differences in Mental Health Risk and Resilience

(2013) S. L. Kigar et al.   JOURNAL OF NEUROENDOCRINOLOGY

“Seq-ing” Insights into the Epigenetics of Neuronal Gene Regulation

(2013) Francesca Telese et al.   NEURON

Stress-induced metaplasticity: From synapses to behavior

(2013) M.V. Schmidt et al.   NEUROSCIENCE

Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain

(2013) D. P. Stuss et al.   NUCLEIC ACIDS RESEARCH

Gender differences in neurodevelopment and epigenetics

(2013) Wilson C. J. Chung et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Understanding Neurological Disease Mechanisms in the Era of Epigenetics

(2013) Irfan A. Qureshi et al.   JAMA Neurology

MicroRNAs and Drug Addiction

(2013) Purva Bali et al.   Frontiers in Genetics

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System

(2012) Marian Mellén et al.   CELL

Phosphorylation of Distinct Sites in MeCP2 Modifies Cofactor Associations and the Dynamics of Transcriptional Regulation

(2012) M. L. Gonzales et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic regulation of BDNF expression according to antidepressant response

(2012) J P Lopez et al.   MOLECULAR PSYCHIATRY

Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity

(2012) Ian Maze et al.   NEUROPSYCHOPHARMACOLOGY

The Role of Histone Acetylation in Cocaine-Induced Neural Plasticity and Behavior

(2012) George A Rogge et al.   NEUROPSYCHOPHARMACOLOGY

Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation

(2012) Danay Baker-Andresen et al.   TRENDS IN NEUROSCIENCES

The Role of MeCP2 in the Brain

(2011) Jacky Guy et al.   Annual Review of Cell and Developmental Biology

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase 

(2011) Lorena Taricani et al.   CELL CYCLE

Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond

(2011) Junjie U. Guo et al.   CELL CYCLE

The Chromatin-binding Protein HMGN1 Regulates the Expression of Methyl CpG-binding Protein 2 (MECP2) and Affects the Behavior of Mice

(2011) Liron Abuhatzira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation

(2011) Malaika K. Singleton et al.   NEUROBIOLOGY OF DISEASE

Cocaine increases phosphorylation of MeCP2 in the rat striatum in vivo: A differential role of NMDA receptors

(2011) Li-Min Mao et al.   NEUROCHEMISTRY INTERNATIONAL

MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

(2011) Anita A. Thambirajah et al.   NUCLEIC ACIDS RESEARCH

Linking Molecules to Mood: New Insight Into the Biology of Depression

(2010) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genes learn from stress: How infantile trauma programs us for depression

(2010) Chris Murgatroyd et al.   Epigenetics

Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression

(2010) Markus Zweier et al.   HUMAN MUTATION

Cocaine-Induced Chromatin Remodeling Increases Brain-Derived Neurotrophic Factor Transcription in the Rat Medial Prefrontal Cortex, Which Alters the Reinforcing Efficacy of Cocaine

(2010) G. Sadri-Vakili et al.   JOURNAL OF NEUROSCIENCE

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

(2010) Peter J. Skene et al.   MOLECULAR CELL

Serum levels of brain-derived neurotrophic factor in major depressive disorder: state–trait issues, clinical features and pharmacological treatment

(2010) M L Molendijk et al.   MOLECULAR PSYCHIATRY

MeCP2 and drug addiction

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212

(2010) Heh-In Im et al.   NATURE NEUROSCIENCE

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

CDKL5 is a brain MeCP2 target gene regulated by DNA methylation

(2010) Delphine Carouge et al.   NEUROBIOLOGY OF DISEASE

DNA Methylation Regulates Cocaine-Induced Behavioral Sensitization in Mice

(2010) Kaili Anier et al.   NEUROPSYCHOPHARMACOLOGY

Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome

(2010) H. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2 post-translational regulation through PEST domains: two novel hypotheses

(2009) Anita A. Thambirajah et al.   BIOESSAYS

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

(2009) Giorgia Bracaglia et al.   EMBO REPORTS

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins

(2009) William Renthal et al.   NEURON

The yin and yang of MeCP2 phosphorylation

(2009) H.-T. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

(2009) J. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetics and the nervous system

(2008) Mark F. Mehler   ANNALS OF NEUROLOGY

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

(2008) Steven W. Flavell et al.   Annual Review of Neuroscience

MeCP2 preferentially binds to methylated linker DNA in the absence of the terminal tail of histone H3 and independently of histone acetylation

(2008) Toyotaka Ishibashi et al.   FEBS LETTERS

Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo

(2008) A. Kumar et al.   JOURNAL OF CELL SCIENCE

Epigenetics in the Nervous System

(2008) Y. Jiang et al.   JOURNAL OF NEUROSCIENCE

The H4 Tail Domain Participates in Intra- and Internucleosome Interactions with Protein and DNA during Folding and Oligomerization of Nucleosome Arrays

(2008) P.-Y. Kan et al.   MOLECULAR AND CELLULAR BIOLOGY

MeCP2 Binding to DNA Depends upon Hydration at Methyl-CpG

(2008) Kok Lian Ho et al.   MOLECULAR CELL

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

(2008) William F. Marzluff et al.   NATURE REVIEWS GENETICS

Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins

(2008) L Lopez-Serra et al.   ONCOGENE

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

Sex differences in drug abuse

(2007) Jill B. Becker et al.   FRONTIERS IN NEUROENDOCRINOLOGY