标题
Targeting tumor cell senescence and polyploidy as potential therapeutic strategies
作者
关键词
Cancer, Senescence, Polyploidy, Chemotherapy, Senolytic
出版物
SEMINARS IN CANCER BIOLOGY
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2020-12-20
DOI
10.1016/j.semcancer.2020.12.010
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Therapy-Induced Senescence Drives Bone Loss
- (2020) Zhangting Yao et al. CANCER RESEARCH
- Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy
- (2020) Tareq Saleh et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Polypoidal giant cancer cells in metastatic castration-resistant prostate cancer: observations from the Michigan Legacy Tissue Program
- (2020) Rahul Mannan et al. MEDICAL ONCOLOGY
- Tamoxifen is a candidate first‐in‐class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells—Unrecognized players in tumorigenesis
- (2020) Shai White‐Gilbertson et al. Cancer Medicine
- BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer
- (2020) Ashkan Shahbandi et al. CELL DEATH AND DIFFERENTIATION
- Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy
- (2020) Tareq Saleh et al. Cancers
- Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells
- (2020) Agnieszka Bojko et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
- (2019) Jamie N. Justice et al. EBioMedicine
- Senolytics and senostatics as adjuvant tumour therapy
- (2019) Susan Short et al. EBioMedicine
- High doses of synthetic antioxidants induce premature senescence in cultivated mesenchymal stem cells
- (2019) Ju. S. Kornienko et al. Scientific Reports
- Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy
- (2019) Tareq Saleh et al. CANCER RESEARCH
- Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer
- (2019) Junsong Chen et al. CURRENT CANCER DRUG TARGETS
- Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
- (2019) Hubert Fleury et al. Nature Communications
- AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
- (2019) Jordi Bertran-Alamillo et al. Nature Communications
- Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
- (2019) Branca I. Pereira et al. Nature Communications
- Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival
- (2019) Crystal A. Tonnessen-Murray et al. JOURNAL OF CELL BIOLOGY
- EMT-related protein expression in polyploid giant cancer cells and their daughter cells with different passages after triptolide treatment
- (2019) Xinlu Wang et al. MEDICAL ONCOLOGY
- A unique morphological phenotype in chemoresistant triple negative breast cancer reveals metabolic reprogramming and PLIN4 expression as a molecular vulnerability
- (2019) Isabelle Sirois et al. MOLECULAR CANCER RESEARCH
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Formation of Polyploid Giant Cancer Cells Involves in the Prognostic Value of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer
- (2019) Fei Fei et al. Journal of Oncology
- Cellular Senescence: Defining a Path Forward
- (2019) Vassilis Gorgoulis et al. CELL
- Inducing and exploiting vulnerabilities for the treatment of liver cancer
- (2019) Cun Wang et al. NATURE
- Identification and characterization of Cardiac Glycosides as senolytic compounds
- (2019) Francisco Triana-Martínez et al. Nature Communications
- Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents
- (2019) Agnieszka Bojko et al. Cells
- NAMPT Inhibition Suppresses Cancer Stem-like Cells Associated with Therapy-Induced Senescence in Ovarian Cancer
- (2019) Timothy Nacarelli et al. CANCER RESEARCH
- A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
- (2019) Sajid Khan et al. NATURE MEDICINE
- A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity
- (2018) David Díaz-Carballo et al. CANCER RESEARCH
- Anti‐cancer therapy: senescence is the new black
- (2018) Rodrigo Leite de Oliveira et al. EMBO JOURNAL
- Chromatin Architectural Changes during Cellular Senescence and Aging
- (2018) Luyang Sun et al. Genes
- Correction to: Comparison of multiple transcriptomes exposes unified and divergent features of quiescent and activated skeletal muscle stem cells
- (2018) Natalia Pietrosemoli et al. Skeletal Muscle
- Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy
- (2018) Tareq Saleh et al. Frontiers in Oncology
- Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
- (2018) Bela Ozsvari et al. Aging-US
- Tumor cell escape from therapy-induced senescence
- (2018) Tareq Saleh et al. BIOCHEMICAL PHARMACOLOGY
- 5-Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy
- (2018) Katarzyna Kornicka et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer
- (2018) Kristina Kovacovicova et al. Frontiers in Oncology
- Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels—An Ex Vivo Study
- (2017) Agnieszka Śmieszek et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas
- (2017) Franciele Cristina Kipper et al. INVESTIGATIONAL NEW DRUGS
- The Clinical Potential of Senolytic Drugs
- (2017) James L. Kirkland et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Senescence-associated reprogramming promotes cancer stemness
- (2017) Maja Milanovic et al. NATURE
- Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells
- (2017) N Niu et al. ONCOGENE
- Identification of HSP90 inhibitors as a novel class of senolytics
- (2017) Heike Fuhrmann-Stroissnigg et al. Nature Communications
- Cellular senescence drives age-dependent hepatic steatosis
- (2017) Mikolaj Ogrodnik et al. Nature Communications
- High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer
- (2017) Liqin Wang et al. Cell Reports
- Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast
- (2017) Wahid A Mulla et al. eLife
- A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC
- (2017) Leleesha Samaraweera et al. Scientific Reports
- NKG2D ligands mediate immunosurveillance of senescent cells
- (2016) Adi Sagiv et al. Aging-US
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
- (2016) Marco Demaria et al. Cancer Discovery
- Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice
- (2016) Halina Was et al. Oncotarget
- Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature
- (2016) Alejandro Vazquez-Martin et al. Oncotarget
- Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
- (2016) Fabrizio Antonangeli et al. OncoImmunology
- Wound-Induced Polyploidy Is Required for Tissue Repair
- (2016) Vicki P. Losick Advances in Wound Care
- Restriction of protein synthesis abolishes senescence features at cellular and organismal levels
- (2016) Yuki Takauji et al. Scientific Reports
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Docetaxel-induced polyploidization may underlie chemoresistance and disease relapse
- (2015) Angela Ogden et al. CANCER LETTERS
- The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells
- (2015) Luis Jaime Castro-Vega et al. CARCINOGENESIS
- The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer
- (2015) Fei Fei et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease
- (2015) Emma L. James et al. JOURNAL OF PROTEOME RESEARCH
- Proteostasis and aging
- (2015) Susmita Kaushik et al. NATURE MEDICINE
- Protein synthesis during cellular quiescence is inhibited by phosphorylation of a translational elongation factor
- (2015) Sandro F. F. Pereira et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype
- (2015) Verena Rohnalter et al. Oncotarget
- Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest
- (2015) Dina Dikovskaya et al. Cell Reports
- Global Reorganization of the Nuclear Landscape in Senescent Cells
- (2015) Tamir Chandra et al. Cell Reports
- Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence
- (2015) Grazyna Mosieniak et al. NEOPLASIA
- Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.
- (2015) Mickaël Ohanna et al. Oncotarget
- Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers
- (2014) Zhanna V Chitikova et al. CELL CYCLE
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging
- (2014) Z. Hu et al. GENES & DEVELOPMENT
- Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors
- (2014) Prudence Donovan et al. Molecular BioSystems
- Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics
- (2014) Sharad Sharma et al. Molecular Oncology
- CoCl2, a Mimic of Hypoxia, Induces Formation of Polyploid Giant Cells with Stem Characteristics in Colon Cancer
- (2014) Laura M. Lopez-Sánchez et al. PLoS One
- Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention
- (2014) D. Lissa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer
- (2014) Channing J. Paller et al. Cancer Medicine
- Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer
- (2014) Jermaine Coward et al. Frontiers in Oncology
- Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin
- (2013) Anna Litwiniec et al. Cancer Cell International
- Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling
- (2013) Guobin He et al. CELL
- Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel
- (2013) Shiwu Zhang et al. INTERNATIONAL JOURNAL OF CANCER
- Inhibition of mTOR Pathway Sensitizes Acute Myeloid Leukemia Cells to Aurora Inhibitors by Suppression of Glycolytic Metabolism
- (2013) L.-L. Liu et al. MOLECULAR CANCER RESEARCH
- Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
- (2013) Jan R. Dörr et al. NATURE
- Generation of cancer stem-like cells through the formation of polyploid giant cancer cells
- (2013) S Zhang et al. ONCOGENE
- Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells
- (2012) Teresa Davoli et al. CANCER CELL
- Expression of cyclin B1 after induction of senescence and cell death in non-small cell lung carcinoma A549 cells
- (2012) Agnieszka Żuryń et al. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- Polyploidy road to therapy-induced cellular senescence and escape
- (2012) Qin Wang et al. INTERNATIONAL JOURNAL OF CANCER
- E2F8 is essential for polyploidization in mammalian cells
- (2012) Shusil K. Pandit et al. NATURE CELL BIOLOGY
- Radiation-Induced Reprogramming of Breast Cancer Cells
- (2012) Chann Lagadec et al. STEM CELLS
- Identification of Aneuploidy-Selective Antiproliferation Compounds
- (2011) Yun-Chi Tang et al. CELL
- Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells
- (2011) Ilio Vitale et al. CELL CYCLE
- Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening models
- (2011) Michal Sabisz et al. CELL CYCLE
- Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5
- (2011) Santiago Rello-Varona et al. CELL CYCLE
- Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species
- (2011) Santhi Achuthan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
- (2011) C Canino et al. ONCOGENE
- The Essence of Quiescence
- (2011) H. A. Coller SCIENCE
- Anticancer therapy with checkpoint inhibitors: what, where and when?
- (2011) Michelle D. Garrett et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Cellular senescence predicts treatment outcome in metastasised colorectal cancer
- (2010) A M Haugstetter et al. BRITISH JOURNAL OF CANCER
- GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells
- (2010) Xianping Shi et al. CANCER BIOLOGY & THERAPY
- Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy
- (2010) Christian Tovar et al. CELL CYCLE
- Polyploidy: The Link Between Senescence and Cancer
- (2010) G. Mosieniak et al. CURRENT PHARMACEUTICAL DESIGN
- Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization
- (2010) O. Jameel Shah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quiescent Fibroblasts Exhibit High Metabolic Activity
- (2010) Johanna M. S. Lemons et al. PLOS BIOLOGY
- A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells
- (2009) Sylvia Mansilla et al. BIOCHEMICAL PHARMACOLOGY
- AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo
- (2009) A. Oke et al. CANCER RESEARCH
- K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells
- (2009) R. Nakai et al. CANCER RESEARCH
- ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
- (2008) C. Tse et al. CANCER RESEARCH
- Endopolyploidy in irradiated p53-deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora-B kinase
- (2008) Jekaterina Erenpreisa et al. CELL BIOLOGY INTERNATIONAL
- Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy
- (2008) Pierre-Emmanuel Puig et al. CELL BIOLOGY INTERNATIONAL
- Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells
- (2008) Malgorzata A. Sliwinska et al. MECHANISMS OF AGEING AND DEVELOPMENT
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started