标题
The Clinical Potential of Senolytic Drugs
作者
关键词
-
出版物
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
Volume 65, Issue 10, Pages 2297-2301
出版商
Wiley
发表日期
2017-09-04
DOI
10.1111/jgs.14969
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cellular senescence mediates fibrotic pulmonary disease
- (2017) Marissa J. Schafer et al. Nature Communications
- Identification of HSP90 inhibitors as a novel class of senolytics
- (2017) Heike Fuhrmann-Stroissnigg et al. Nature Communications
- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
- (2016) Carolyn M. Roos et al. AGING CELL
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
- (2016) Brandon M. Hall et al. Aging-US
- Fisetin inhibits laryngeal carcinoma through regulation of AKT/NF-κB/mTOR and ERK1/2 signaling pathways
- (2016) Xi-Jun Zhang et al. BIOMEDICINE & PHARMACOTHERAPY
- Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms: Table 1.
- (2016) Christin E. Burd et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Resilience in Aging Mice
- (2016) James L. Kirkland et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience
- (2016) Derek M. Huffman et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes
- (2016) Jamie Justice et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Strategies and Challenges in Clinical Trials Targeting Human Aging
- (2016) John C. Newman et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Senescent intimal foam cells are deleterious at all stages of atherosclerosis
- (2016) B. G. Childs et al. SCIENCE
- Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy
- (2016) M. Oubaha et al. Science Translational Medicine
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- Translating the Science of Aging into Therapeutic Interventions
- (2016) James L. Kirkland Cold Spring Harbor Perspectives in Medicine
- Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
- (2016) Michael B. Stout et al. Aging-US
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Clinical strategies and animal models for developing senolytic agents
- (2015) James L. Kirkland et al. EXPERIMENTAL GERONTOLOGY
- Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway
- (2015) Feng Wang et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
- (2015) Ming Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicity
- (2015) J. L. St Sauver et al. BMJ Open
- Targeting senescent cells enhances adipogenesis and metabolic function in old age
- (2015) Ming Xu et al. eLife
- Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death
- (2014) P Makhov et al. BRITISH JOURNAL OF CANCER
- Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
- (2014) Evandro Fei Fang et al. CELL
- Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
- (2014) Yi Zhu et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis
- (2014) James H. Tabibian et al. HEPATOLOGY
- Aging and Risk of Severe, Disabling, Life-Threatening, and Fatal Events in the Childhood Cancer Survivor Study
- (2014) Gregory T. Armstrong et al. JOURNAL OF CLINICAL ONCOLOGY
- mTOR inhibition improves immune function in the elderly
- (2014) J. B. Mannick et al. Science Translational Medicine
- Fisetin inhibits growth, induces G2/M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation
- (2013) Harish C. Pal et al. EXPERIMENTAL DERMATOLOGY
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- The number of p16INK4a positive cells in human skin reflects biological age
- (2012) Mariëtte E.C. Waaijer et al. AGING CELL
- Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells
- (2012) Konstantin V. Golovine et al. PROSTATE
- Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
- (2012) Mitra Lavasani et al. Nature Communications
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Fat tissue, aging, and cellular senescence
- (2010) Tamara Tchkonia et al. AGING CELL
- Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence
- (2010) You-Mie Kim et al. Annals of the New York Academy of Sciences
- Fisetin, a Dietary Flavonoid, Induces Cell Cycle Arrest and Apoptosis through Activation of p53 and Inhibition of NF-Kappa B Pathways in Bladder Cancer Cells
- (2010) Jing Li et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Flavonoids induce HIF-1α but impair its nuclear accumulation and activity
- (2007) Anastasia Triantafyllou et al. FREE RADICAL BIOLOGY AND MEDICINE
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