Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents

The senescence-associated secretory phenotype and its regulation

(2019) Stéphane Lopes-Paciencia et al.   CYTOKINE

Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy

(2019) Chien-Hsiang Hsu et al.   CELL

Targeting normal and cancer senescent cells as a strategy of senotherapy

(2019) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Oxidative stress and inhibition of nitric oxide generation underlie methotrexate-induced senescence in human colon cancer cells

(2018) Magdalena Dabrowska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Stress, cell senescence and organismal ageing

(2018) João Pedro de Magalhães et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Is DNA damage indispensable for stress-induced senescence?

(2018) Anna Bielak-Zmijewska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells

(2018) Anna Strzeszewska et al.   Cell Death & Disease

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

ATM is required for the repair of oxaliplatin-induced DNA damage in colorectal cancer

(2018) Christopher J. Bakkenist et al.   Clinical Colorectal Cancer

Autophagy Governs Protumorigenic Effects of Mitotic Slippage–induced Senescence

(2018) Rekha Jakhar et al.   MOLECULAR CANCER RESEARCH

53BP1: A key player of DNA damage response with critical functions in cancer

(2018) Mohammad Mirza-Aghazadeh-Attari et al.   DNA REPAIR

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

(2017) Liqin Wang et al.   Cell Reports

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy

(2017) Markus Schosserer et al.   Frontiers in Oncology

Multiple facets of p53 in senescence induction and maintenance

(2016) Yoshikazu Johmura et al.   CANCER SCIENCE

Morphological and Functional Characteristic of Senescent Cancer Cells

(2016) Ewa Sikora et al.   CURRENT DRUG TARGETS

Curcumin-treated cancer cells show mitotic disturbances leading to growth arrest and induction of senescence phenotype

(2016) Grażyna Mosieniak et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

(2016) Panagiotis Galanos et al.   NATURE CELL BIOLOGY

Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells

(2016) Lisha Xie et al.   OncoTargets and Therapy

Is senescence-associated β-galactosidase a marker of neuronal senescence?

(2016) Malgorzata Piechota et al.   Oncotarget

ATM and ATR signaling at a glance

(2015) P. Awasthi et al.   JOURNAL OF CELL SCIENCE

ATM and ATR as therapeutic targets in cancer

(2015) Anika Maria Weber et al.   PHARMACOLOGY & THERAPEUTICS

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Different Mutant/Wild-Type p53 Combinations Cause a Spectrum of Increased Invasive Potential in Nonmalignant Immortalized Human Mammary Epithelial Cells

(2015) Damian J. Junk et al.   NEOPLASIA

Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer

(2013) Ruiwu Liu et al.   Future Medicinal Chemistry

Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells

(2012) Z. Korwek et al.   DNA REPAIR

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

p21 as a Transcriptional Co-Repressor of S-Phase and Mitotic Control Genes

(2012) Nuria Ferrándiz et al.   PLoS One

Senescence: a new weapon for cancer therapy

(2012) Juan Carlos Acosta et al.   TRENDS IN CELL BIOLOGY

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Novel ARF/p53-independent senescence pathways in cancer repression

(2011) Chia-Hsin Chan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1

(2011) Anne Bothmer et al.   MOLECULAR CELL

Quantitative assessment of markers for cell senescence

(2010) Conor Lawless et al.   EXPERIMENTAL GERONTOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy

(2008) E. Crescenzi et al.   CLINICAL CANCER RESEARCH

Cellular senescence in vivo: a barrier to tumorigenesis

(2008) Alexandre Prieur et al.   CURRENT OPINION IN CELL BIOLOGY

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

(2008) Malgorzata A. Sliwinska et al.   MECHANISMS OF AGEING AND DEVELOPMENT