Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

Chromatin modifications: The driving force of senescence and aging?

(2016) Teresa DiMauro et al.   Aging-US

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

(2016) Lioubov G. Korotchkina et al.   Aging-US

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Rapamycin induces pluripotent genes associated with avoidance of replicative senescence

(2013) Tatyana V. Pospelova et al.   CELL CYCLE

Brief Report: Impaired Cell Reprogramming in Nonhomologous End Joining Deficient Cells

(2013) F. Javier Molina-Estevez et al.   STEM CELLS

Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State

(2013) Federico González et al.   Cell Reports

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

(2012) Marina Kolesnichenko et al.   CELL CYCLE

Suppression of replicative senescence by rapamycin in rodent embryonic cells

(2012) Tatyana V. Pospelova et al.   CELL CYCLE

Polyploidy road to therapy-induced cellular senescence and escape

(2012) Qin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells

(2012) Asao Noda et al.   JOURNAL OF CELL SCIENCE

Nanog signaling in cancer promotes stem-like phenotype and immune evasion

(2012) Kyung Hee Noh et al.   JOURNAL OF CLINICAL INVESTIGATION

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography

(2012) Larry H. Thompson   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Heterogeneity in Radiation-Induced DNA Damage and Repair in Tumor and Normal Cells Measured Using the “Comet” Assay

(2012) Peggy L. Olive et al.   RADIATION RESEARCH

Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression

(2012) Li Zheng et al.   Nature Communications

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

A DNA Repair Complex Functions as an Oct4/Sox2 Coactivator in Embryonic Stem Cells

(2011) Yick W. Fong et al.   CELL

Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation

(2011) Jekaterina Erenpreisa et al.   CELL BIOLOGY INTERNATIONAL

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Pseudo-DNA damage response in senescent cells

(2011) Tatyana V. Pospelova et al.   CELL CYCLE

mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging

(2011) Javier A. Menendez et al.   CELL CYCLE

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

(2011) Martin Kosar et al.   CELL CYCLE

NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation

(2011) C R Jeter et al.   ONCOGENE

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation

(2010) S.-H. Chiou et al.   CANCER RESEARCH

Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells

(2010) Kristine Salmina et al.   EXPERIMENTAL CELL RESEARCH

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Paradoxical suppression of cellular senescence by p53

(2010) Z. N. Demidenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-damaged polyploid cancer cells can reverse to diploidy: An ordered, but little understood, process of genomic reduction [with reference to the previous comments of Forer (2008) and Wheatley (2008a and b)]

(2009) François Martin et al.   CELL BIOLOGY INTERNATIONAL

Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells

(2009) Bo Feng et al.   Cell Stem Cell

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Regulation of Protein Synthesis by Ionizing Radiation

(2009) S. Braunstein et al.   MOLECULAR AND CELLULAR BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Oct-3/4 Expression Reflects Tumor Progression and Regulates Motility of Bladder Cancer Cells

(2008) C.-C. Chang et al.   CANCER RESEARCH

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

(2008) Asako J Nakamura et al.   Epigenetics & Chromatin