Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells

The Dualistic Model of Ovarian Carcinogenesis

(2016) Robert J. Kurman et al.   AMERICAN JOURNAL OF PATHOLOGY

Is Senescence Reversible?

(2016) Shweta Chakradeo et al.   CURRENT DRUG TARGETS

Linking genomic reorganization to tumor initiation via the giant cell cycle

(2016) N Niu et al.   Oncogenesis

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

(2016) Eike-Benjamin Braune et al.   Stem Cell Reports

Docetaxel-induced polyploidization may underlie chemoresistance and disease relapse

(2015) Angela Ogden et al.   CANCER LETTERS

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells

(2015) C Leikam et al.   Cell Death & Disease

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

(2014) Kotaro Ohnishi et al.   CELL

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

GATA6 Levels Modulate Primitive Endoderm Cell Fate Choice and Timing in the Mouse Blastocyst

(2014) Nadine Schrode et al.   DEVELOPMENTAL CELL

Atypical embryo phenotypes identified by time-lapse microscopy: high prevalence and association with embryo development

(2014) Kelly Athayde Wirka et al.   FERTILITY AND STERILITY

Analysis of compaction initiation in human embryos by using time-lapse cinematography

(2014) Kyoko Iwata et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CoCl2, a Mimic of Hypoxia, Induces Formation of Polyploid Giant Cells with Stem Characteristics in Colon Cancer

(2014) Laura M. Lopez-Sánchez et al.   PLoS One

Pax6 Regulates the Expression of Dkk3 in Murine and Human Cell Lines, and Altered Responses to Wnt Signaling Are Shown in FlpIn-3T3 Cells Stably Expressing Either the Pax6 or the Pax6(5a) Isoform

(2014) Siri Forsdahl et al.   PLoS One

Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles

(2014) L. M. Zasadil et al.   Science Translational Medicine

DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells

(2014) Hsu-Hsin Chen et al.   Stem Cell Reports

Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo

(2013) Shiwu Zhang et al.   CANCER LETTERS

Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel

(2013) Shiwu Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies

(2013) Andrew S Lee et al.   NATURE MEDICINE

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

Endoreplication

(2013) N. Zielke et al.   Cold Spring Harbor Perspectives in Biology

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

Endoreplication and polyploidy: insights into development and disease

(2012) D. T. Fox et al.   DEVELOPMENT

Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

(2012) A. Mertzanidou et al.   HUMAN REPRODUCTION

Polyploidy road to therapy-induced cellular senescence and escape

(2012) Qin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

(2012) Shawn L. Chavez et al.   Nature Communications

Formation of solid tumors by a single multinucleated cancer cell

(2011) Zhang Weihua et al.   CANCER

Expression and distribution of immunoglobulin G and its receptors in an immune privileged site: the eye

(2010) Na Niu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stanniocalcin 1 and Ovarian Tumorigenesis

(2010) Guangzhi Liu et al.   JNCI-Journal of the National Cancer Institute

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Chaos in the embryo

(2009) David H Ledbetter   NATURE MEDICINE

Chromosome instability is common in human cleavage-stage embryos

(2009) Evelyne Vanneste et al.   NATURE MEDICINE

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL