Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity

(2018) David Díaz-Carballo et al.   CANCER RESEARCH

Multinucleated Giant Cancer Cells Produced in Response to Ionizing Radiation Retain Viability and Replicate Their Genome

(2017) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells

(2017) N Niu et al.   ONCOGENE

Morphological and Functional Characteristic of Senescent Cancer Cells

(2016) Ewa Sikora et al.   CURRENT DRUG TARGETS

Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability

(2016) Shengyao Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Linking genomic reorganization to tumor initiation via the giant cell cycle

(2016) N Niu et al.   Oncogenesis

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

(2016) Eike-Benjamin Braune et al.   Stem Cell Reports

Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences

(2015) Brittany L. Daughtry et al.   CELL AND TISSUE RESEARCH

When bigger is better: the role of polyploidy in organogenesis

(2015) Terry L. Orr-Weaver   TRENDS IN GENETICS

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells

(2015) C Leikam et al.   Cell Death & Disease

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype

(2015) Verena Rohnalter et al.   Oncotarget

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

(2015) Dina Dikovskaya et al.   Cell Reports

A Fraction of CD133+ CNE2 Cells Is Made of Giant Cancer Cells with Morphological Evidence of Asymmetric Mitosis

(2015) Qingping Jiang et al.   Journal of Cancer

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor

(2014) Hongcheng Lv et al.   BMC CANCER

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

Coming Full Circle—From Endless Complexity to Simplicity and Back Again

(2014) Robert A. Weinberg   CELL

Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

(2014) Zhanna V Chitikova et al.   CELL CYCLE

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Atypical embryo phenotypes identified by time-lapse microscopy: high prevalence and association with embryo development

(2014) Kelly Athayde Wirka et al.   FERTILITY AND STERILITY

Analysis of compaction initiation in human embryos by using time-lapse cinematography

(2014) Kyoko Iwata et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo

(2013) Shiwu Zhang et al.   CANCER LETTERS

Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel

(2013) Shiwu Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents

(2013) S. Sharma et al.   MOLECULAR CANCER THERAPEUTICS

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

iTRAQ-Based Proteomic Analysis of Polyploid Giant Cancer Cells and Budding Progeny Cells Reveals Several Distinct Pathways for Ovarian Cancer Development

(2013) Shiwu Zhang et al.   PLoS One

Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells

(2013) B. Rengstl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoreplication

(2013) N. Zielke et al.   Cold Spring Harbor Perspectives in Biology

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells

(2012) Lizhou Jia et al.   CANCER LETTERS

Endoreplication and polyploidy: insights into development and disease

(2012) D. T. Fox et al.   DEVELOPMENT

Radiation-Induced Reprogramming of Breast Cancer Cells

(2012) Chann Lagadec et al.   STEM CELLS

Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

(2012) Shawn L. Chavez et al.   Nature Communications

The Causes and Consequences of Polyploidy in Normal Development and Cancer

(2011) Teresa Davoli et al.   Annual Review of Cell and Developmental Biology

Formation of solid tumors by a single multinucleated cancer cell

(2011) Zhang Weihua et al.   CANCER

Breakage-fusion-bridge cycles leading to inv dup del occur in human cleavage stage embryos

(2011) Thierry Voet et al.   HUMAN MUTATION

Mitosis is not the only distributor of mutated cells: non-mitotic endopolyploid cells produce reproductive genome-reduced cells

(2010) Kirsten H Walen   CELL BIOLOGY INTERNATIONAL

Polyploidy: The Link Between Senescence and Cancer

(2010) G. Mosieniak et al.   CURRENT PHARMACEUTICAL DESIGN

Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells

(2010) Kristine Salmina et al.   EXPERIMENTAL CELL RESEARCH

Cell Fusion as a Hidden Force in Tumor Progression

(2009) X. Lu et al.   CANCER RESEARCH

Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-Induced Mitotic Catastrophe

(2009) F. Ianzini et al.   CANCER RESEARCH

Endoreplication: polyploidy with purpose

(2009) H. O. Lee et al.   GENES & DEVELOPMENT

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS