Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by Legionella

The bacterial deubiquitinase Ceg23 regulates the association of Lys-63–linked polyubiquitin molecules on the Legionella phagosome

(2020) Kelong Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterizing the microbiomes of Antarctic sponges: a functional metagenomic approach

(2020) Mario Moreno-Pino et al.   Scientific Reports

Phosphoinositides and the Fate of Legionella in Phagocytes

(2020) A. Leoni Swart et al.   Frontiers in Immunology

Combinatorial selection in amoebal hosts drives the evolution of the human pathogen Legionella pneumophila

(2020) Jason M. Park et al.   Nature Microbiology

Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector

(2020) Christopher Price et al.   Cell Host & Microbe

A Legionella effector kinase is activated by host inositol hexakisphosphate

(2020) Anju Sreelatha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets

(2020) A. Leoni Swart et al.   mBio

Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex

(2020) Hyunmin Kim et al.   Nature Communications

TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation

(2020) Pei-Chung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mimicry of Short Linear Motifs by Bacterial Pathogens: A Drugging Opportunity

(2020) Hugo Sámano-Sánchez et al.   TRENDS IN BIOCHEMICAL SCIENCES

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

(2019) Laura Gomez-Valero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis

(2019) Steven M. Moss et al.   Cell Host & Microbe

The Other Side of the Coin: What Beneficial Microbes Can Teach Us about Pathogenic Potential

(2019) Travis J. Wiles et al.   JOURNAL OF MOLECULAR BIOLOGY

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

(2019) Miles H. Black et al.   SCIENCE

A bacterial effector deubiquitinase specifically hydrolyses linear ubiquitin chains to inhibit host inflammatory signalling

(2019) Muyang Wan et al.   Nature Microbiology

Intracellular parasitism, the driving force of evolution of Legionella pneumophila and the genus Legionella

(2019) Laure Gomez-Valero et al.   MICROBES AND INFECTION

Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase

(2019) Ninghai Gan et al.   NATURE

Inhibition of bacterial ubiquitin ligases by SidJ–calmodulin-catalysed glutamylation

(2019) Sagar Bhogaraju et al.   NATURE

Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex

(2019) Juanita Von Dwingelo et al.   mBio

Legionnaires’ Disease: State of the Art Knowledge of Pathogenesis Mechanisms of Legionella

(2019) Sonia Mondino et al.   Annual Review of Pathology-Mechanisms of Disease

Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB

(2019) Donghyuk Shin et al.   MOLECULAR CELL

Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ

(2019) Alan Sulpizio et al.   eLife

LotA, a Legionella deubiquitinase, has dual catalytic activity and contributes to intracellular growth

(2018) Tomoko Kubori et al.   CELLULAR MICROBIOLOGY

Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg-like metabolism?

(2018) Pedro Escoll et al.   FEBS Journal

TheLegionella pneumophilaeffector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways

(2018) Andrew T. Quaile et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Legionella pneumophilaeffector Lem4 is a membrane-associated protein tyrosine phosphatase

(2018) Ksenia Beyrakhova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection

(2018) Maren Kirstin Schuhmacher et al.   JOURNAL OF MOLECULAR BIOLOGY

A Legionella pneumophila amylase is essential for intracellular replication in human macrophages and amoebae

(2018) Ashley Best et al.   Scientific Reports

RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases

(2018) Yi-Han Lin et al.   PLoS Pathogens

The Legionella Effector Kinase LegK7 Hijacks the Host Hippo Pathway to Promote Infection

(2018) Pei-Chung Lee et al.   Cell Host & Microbe

Revisiting Bacterial Ubiquitin Ligase Effectors: Weapons for Host Exploitation

(2018) Antonio Pisano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase

(2018) Nadezhda Levanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncovering the Structural Basis of a New Twist in Protein Ubiquitination

(2018) Kedar Puvar et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification and characterization of a large family of superbinding bacterial SH2 domains

(2018) Tomonori Kaneko et al.   Nature Communications

Comparative Genomic Analysis of Acanthamoeba Endosymbionts Highlights the Role of Amoebae as a “Melting Pot” Shaping the Rickettsiales Evolution

(2017) Zhang Wang et al.   Genome Biology and Evolution

Expression of eukaryotic-like protein in the microbiome of sponges

(2017) C. Díez-Vives et al.   MOLECULAR ECOLOGY

Free-Living Amoebae as Hosts for and Vectors of Intracellular Microorganisms with Public Health Significance

(2017) Carsten Balczun et al.   Viruses-Basel

Hijacking of the Host Ubiquitin Network by Legionella pneumophila

(2017) Jiazhang Qiu et al.   Frontiers in Cellular and Infection Microbiology

From Many Hosts, One Accidental Pathogen: The Diverse Protozoan Hosts of Legionella

(2017) David K. Boamah et al.   Frontiers in Cellular and Infection Microbiology

The Multifaceted Role of SNARE Proteins in Membrane Fusion

(2017) Jing Han et al.   Frontiers in Physiology

Divergent evolution of Di-lysine ER retention vs. farnesylation motif-mediated anchoring of the AnkB virulence effector to the Legionella-containing vacuolar membrane

(2017) John D. Perpich et al.   Scientific Reports

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

(2016) Sagar Bhogaraju et al.   CELL

Legionella pneumophila, armed to the hilt: justifying the largest arsenal of effectors in the bacterial world

(2016) Alexander W Ensminger   CURRENT OPINION IN MICROBIOLOGY

Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila

(2016) Malene L Urbanus et al.   Molecular Systems Biology

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

(2016) Jiazhang Qiu et al.   NATURE

Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires

(2016) David Burstein et al.   NATURE GENETICS

Direct targeting of membrane fusion by SNARE mimicry: Convergent evolution ofLegionellaeffectors

(2016) Xingqi Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Legionella pneumophilaS1P-lyase targets host sphingolipid metabolism and restrains autophagy

(2016) Monica Rolando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen mimicry of host protein-protein interfaces modulates immunity

(2016) Emine Guven-Maiorov et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Legionella pneumophila Type IV Effectors YlfA and YlfB Are SNARE-Like Proteins that Form Homo- and Heteromeric Complexes and Enhance the Efficiency of Vacuole Remodeling

(2016) Eva M. Campodonico et al.   PLoS One

Crystal structure of Legionella pneumophila type IV secretion system effector LegAS4

(2015) Jonghyeon Son et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors

(2015) Ernest C. So et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Soluble NSF attachment protein receptor molecular mimicry by aLegionella pneumophila Dot/Icm effector

(2015) Nathan P. King et al.   CELLULAR MICROBIOLOGY

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor

(2015) Gunnar N. Schroeder et al.   INFECTION AND IMMUNITY

Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy

(2015) Pedro Escoll et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination

(2015) Michael J. Sheedlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila

(2015) Andrew T. Quaile et al.   STRUCTURE

How pathogens use linear motifs to perturb host cell networks

(2015) Allegra Via et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway

(2015) Céline Michard et al.   mBio

The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase

(2015) Ali Flayhan et al.   Scientific Reports

Discovery of Novel Plant Interaction Determinants from the Genomes of 163 Root Nodule Bacteria

(2015) Rekha Seshadri et al.   Scientific Reports

The Legionella pneumophila Effector Protein, LegC7, Alters Yeast Endosomal Trafficking

(2015) Kevin M. O’Brien et al.   PLoS One

Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication ofLegionella pneumophila

(2014) Patrice Riedmaier et al.   BIOCHEMICAL JOURNAL

Icm/Dot-dependent inhibition of phagocyte migration byLegionellais antagonized by a translocated Ran GTPase activator

(2014) Sylvia Simon et al.   CELLULAR MICROBIOLOGY

Arfs at a Glance

(2014) C. L. Jackson et al.   JOURNAL OF CELL SCIENCE

Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell

(2014) Monica Rolando et al.   TRENDS IN CELL BIOLOGY

Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires¿ disease

(2014) Laura Gomez-Valero et al.   GENOME BIOLOGY

Bacterial SET domain proteins and their role in eukaryotic chromatin modification

(2014) Raúl Alvarez-Venegas   Frontiers in Genetics

Legionella pneumophila Effector RomA Uniquely Modifies Host Chromatin to Repress Gene Expression and Promote Intracellular Bacterial Replication

(2013) Monica Rolando et al.   Cell Host & Microbe

SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription

(2013) Ting Li et al.   EMBO REPORTS

Anthrax SET Protein

(2013) Shiraz Mujtaba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ankyrin-repeat proteins from sponge symbionts modulate amoebal phagocytosis

(2013) Mary T. H. D. Nguyen et al.   MOLECULAR ECOLOGY

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

LegC3, an Effector Protein from Legionella pneumophila, Inhibits Homotypic Yeast Vacuole Fusion In Vivo and In Vitro

(2013) Terry L. Bennett et al.   PLoS One

Molecular Mechanisms of SH2- and PTB-Domain-Containing Proteins in Receptor Tyrosine Kinase Signaling

(2013) M. J. Wagner et al.   Cold Spring Harbor Perspectives in Biology

Genome Dynamics in Legionella: The Basis of Versatility and Adaptation to Intracellular Replication

(2013) L. Gomez-Valero et al.   Cold Spring Harbor Perspectives in Medicine

Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection

(2013) Eva Rothmeier et al.   PLoS Pathogens

The Ubiquitin System, an Immense Realm

(2012) Alexander Varshavsky   Annual Review of Biochemistry

When bacteria target the nucleus: the emerging family of nucleomodulins

(2012) Hélène Bierne et al.   CELLULAR MICROBIOLOGY

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Legionella pneumophila Secretes a Mitochondrial Carrier Protein during Infection

(2012) Pavel Dolezal et al.   PLoS Pathogens

Identification of Two Legionella pneumophila Effectors that Manipulate Host Phospholipids Biosynthesis

(2012) Ram Viner et al.   PLoS Pathogens

Insight into cross-talk between intra-amoebal pathogens

(2011) Gregory Gimenez et al.   BMC GENOMICS

Molecular Mimicry as a Mechanism of Autoimmune Disease

(2011) Matthew F. Cusick et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Protein Kinase LegK2 Is a Type IV Secretion System Effector Involved in Endoplasmic Reticulum Recruitment and Intracellular Replication of Legionella pneumophila

(2011) Eva Hervet et al.   INFECTION AND IMMUNITY

GamA is a eukaryotic-like glucoamylase responsible for glycogen- and starch-degrading activity of Legionella pneumophila

(2011) Vroni Herrmann et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The Coxiella burnetii Cryptic Plasmid Is Enriched in Genes Encoding Type IV Secretion System Substrates

(2011) D. E. Voth et al.   JOURNAL OF BACTERIOLOGY

Genome-Wide Identification of Molecular Mimicry Candidates in Parasites

(2011) Philipp Ludin et al.   PLoS One

Host Proteasomal Degradation Generates Amino Acids Essential for Intracellular Bacterial Growth

(2011) C. T. D. Price et al.   SCIENCE

Comparative and Functional Genomics of Legionella Identified Eukaryotic Like Proteins as Key Players in Host?Pathogen Interactions

(2011) Laura Gomez-Valero et al.   Frontiers in Microbiology

The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication

(2010) M. Lomma et al.   CELLULAR MICROBIOLOGY

Molecular Pathogenesis of Infections Caused by Legionella pneumophila

(2010) H. J. Newton et al.   CLINICAL MICROBIOLOGY REVIEWS

Genome analysis of microorganisms living in amoebae reveals a melting pot of evolution

(2010) Claire Moliner et al.   FEMS MICROBIOLOGY REVIEWS

The origins of eukaryotic-like proteins in Legionella pneumophila

(2010) Mor N. Lurie-Weinberger et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Lipidation by the Host Prenyltransferase Machinery Facilitates Membrane Localization ofLegionella pneumophilaEffector Proteins

(2010) Stanimir S. Ivanov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector ofLegionella pneumophila

(2010) Christopher T.D. Price et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effective--a database of predicted secreted bacterial proteins

(2010) M.-A. Jehl et al.   NUCLEIC ACIDS RESEARCH

Analysis of the Legionella longbeachae Genome and Transcriptome Uncovers Unique Strategies to Cause Legionnaires' Disease

(2010) Christel Cazalet et al.   PLoS Genetics

Legionella Metaeffector Exploits Host Proteasome to Temporally Regulate Cognate Effector

(2010) Tomoko Kubori et al.   PLoS Pathogens

Histone Methylation by NUE, a Novel Nuclear Effector of the Intracellular Pathogen Chlamydia trachomatis

(2010) Meghan E. Pennini et al.   PLoS Pathogens

ALegionellaeffector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria

(2009) Elena Degtyar et al.   CELLULAR MICROBIOLOGY

The Genome of the Amoeba Symbiont "Candidatus Amoebophilus asiaticus" Reveals Common Mechanisms for Host Cell Interaction among Amoeba-Associated Bacteria

(2009) S. Schmitz-Esser et al.   JOURNAL OF BACTERIOLOGY

Legionella, Protozoa, and Biofilms: Interactions Within Complex Microbial Systems

(2009) Michael Taylor et al.   MICROBIAL ECOLOGY

The evolutionary conundrum of pathogen mimicry

(2009) Nels C. Elde et al.   NATURE REVIEWS MICROBIOLOGY

A Legionella type IV effector activates the NF- B pathway by phosphorylating the I B family of inhibitors

(2009) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mimicry by an F-Box Effector of Legionella pneumophila Hijacks a Conserved Polyubiquitination Machinery within Macrophages and Protozoa

(2009) Christopher T. Price et al.   PLoS Pathogens

The RCC1 superfamily: From genes, to function, to disease

(2008) Ouadah Hadjebi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteomic Characterization of the Whole Secretome of Legionella pneumophila and Functional Analysis of Outer Membrane Vesicles

(2008) F. Galka et al.   INFECTION AND IMMUNITY

Enzymatic Properties of an Ecto-nucleoside Triphosphate Diphosphohydrolase fromLegionella pneumophila

(2008) Fiona M. Sansom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dot/Icm-translocated ankyrin protein ofLegionella pneumophilais required for intracellular proliferation within human macrophages and protozoa

(2008) Souhaila Al-Khodor et al.   MOLECULAR MICROBIOLOGY

Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions

(2008) Tomoko Kubori et al.   MOLECULAR MICROBIOLOGY

I never met a microbe I didn't like

(2008) Stanley Falkow   NATURE MEDICINE

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

(2008) Ralph R. Isberg et al.   NATURE REVIEWS MICROBIOLOGY