Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependent

(2020) Jiyu Zhang et al.   Emerging Microbes & Infections

Duchenne muscular dystrophy is associated with the inhibition of calcium uniport in mitochondria and an increased sensitivity of the organelles to the calcium-induced permeability transition

(2020) Mikhail V. Dubinin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reperfusion injury as a target for diminishing infarct size

(2020) A. Barzyc et al.   MEDICAL HYPOTHESES

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore

(2019) Maria A. Neginskaya et al.   Cell Reports

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

SPG7 targets the m-AAA protease complex to process MCU for uniporter assembly, Ca2+ influx, and regulation of mPTP opening

(2019) Stephen Hurst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care

(2019) Anna Tarocco et al.   Cell Death & Disease

LRPPRC: A Multifunctional Protein Involved in Energy Metabolism and Human Disease

(2019) Jie Cui et al.   Frontiers in Physiology

Small-molecule inhibitors of cyclophilins block opening of the mitochondrial permeability transition pore and protect mice from hepatic ischemia–reperfusion injury

(2019) Mathieu Panel et al.   GASTROENTEROLOGY

Correlation between auto/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients

(2019) Massimiliano Castellazzi et al.   Journal of Neuroinflammation

Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI

(2019) Shrikant Ramesh Mulay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase

(2019) Joe Carroll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

(2019) Jason Karch et al.   Science Advances

Olesoxime in neurodegenerative diseases: Scrutinising a promising drug candidate

(2019) Jonasz Jeremiasz Weber et al.   BIOCHEMICAL PHARMACOLOGY

Comparison of multiple doses of cyclosporine A on germ cell apoptosis and epididymal sperm parameters after testicular ischemia/reperfusion in rats

(2019) Iraj Yazdani et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies

(2019) Ricardo O. S. Soares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

(2019) Atsushi Hoshino et al.   NATURE

Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore

(2019) Andrea Urbani et al.   Nature Communications

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

A mitochondrial megachannel resides in monomeric F1FO ATP synthase

(2019) Nelli Mnatsakanyan et al.   Nature Communications

Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment

(2019) Massimiliano Castellazzi et al.   Scientific Reports

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis

(2018) Xiaolei Wang et al.   HEPATOLOGY

Cyclosporine A does not prevent second-eye involvement in Leber’s hereditary optic neuropathy

(2018) Stéphanie Leruez et al.   Orphanet Journal of Rare Diseases

Calcium Dynamics as a Machine for Decoding Signals

(2018) Carlotta Giorgi et al.   TRENDS IN CELL BIOLOGY

Porcine deltacoronavirus induces caspase-dependent apoptosis through activation of the cytochrome c -mediated intrinsic mitochondrial pathway

(2018) Yoo Jin Lee et al.   VIRUS RESEARCH

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction

(2018) Giampaolo Morciano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

(2018) Massimo Bonora et al.   Nature Reviews Cardiology

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Otilonium and pinaverium trigger mitochondrial-mediated apoptosis in rat embryo cortical neurons in vitro

(2018) Fernanda García-Alvarado et al.   NEUROTOXICOLOGY

Ochratoxin A-Induced Apoptosis of IPEC-J2 Cells through ROS-Mediated Mitochondrial Permeability Transition Pore Opening Pathway

(2017) Hong Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Autophagy and mitophagy elements are increased in body fluids of multiple sclerosis-affected individuals

(2017) Simone Patergnani et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

A Mechanism Study Underlying the Protective Effects of Cyclosporine-A on Lung Ischemia-Reperfusion Injury

(2017) Jian''an Li et al.   PHARMACOLOGY

CC-223 blocks mTORC1/C2 activation and inhibits human hepatocellular carcinoma cells in vitro and in vivo

(2017) Zichen Xie et al.   PLoS One

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel function of the tumor suppressor PML at ER-mitochondria sites in the control of autophagy

(2017) Sonia Missiroli et al.   Oncotarget

ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca 2+ signaling

(2016) Mart Bittremieux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Exogenous spermine inhibits hypoxia/ischemia-induced myocardial apoptosis via regulation of mitochondrial permeability transition pore and associated pathways

(2016) Can Wei et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Skeletal muscle ischemia-reperfusion injury and cyclosporine A in the aging rat

(2016) Julien Pottecher et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: Preliminary findings

(2016) Gianluca Campo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

OPA1 processing in cell death and disease – the long and short of it

(2016) Thomas MacVicar et al.   JOURNAL OF CELL SCIENCE

Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis

(2016) Emma R. Shore et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion

(2016) Farinoosh Fakharnia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cyclosporine A in Reperfused Myocardial Infarction

(2016) Filippo Ottani et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons

(2016) Z. Ou et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson’s disease

(2016) Md Zeeshan Rasheed et al.   PROTOPLASMA

The mitochondrion interfering compound NPC-26 exerts potent anti-pancreatic cancer cell activity in vitro and in vivo

(2016) Yang-Yang Dong et al.   TUMOR BIOLOGY

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

(2016) Sonia Missiroli et al.   Cell Reports

Alterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 Mutants

(2016) Carlotta Giorgi et al.   Frontiers in Oncology

Caspase-Dependent and Caspase-Independent Pathways Are Involved in Cadmium-Induced Apoptosis in Primary Rat Proximal Tubular Cell Culture

(2016) Gang Liu et al.   PLoS One

Inside the tumor: p53 modulates calcium homeostasis

(2015) Carlotta Giorgi et al.   CELL CYCLE

Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy

(2015) A R Burr et al.   CELL DEATH AND DIFFERENTIATION

Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

(2015) Sudeshna Roy et al.   ChemMedChem

N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

(2015) Sudeshna Roy et al.   ChemMedChem

Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia–reperfusion

(2015) Kaori Shintani-Ishida et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

(2015) Justin Warne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

(2015) Santhanam Shanmughapriya et al.   MOLECULAR CELL

Bufalin induces apoptosis in the U-2OS human osteosarcoma cell line via triggering the mitochondrial pathway

(2015) YA CHEN et al.   Molecular Medicine Reports

Mitochondrial DNA sequence variation in multiple sclerosis

(2015) Gregory J. Tranah et al.   NEUROLOGY

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel frontiers in calcium signaling: A possible target for chemotherapy

(2015) Massimo Bonora et al.   PHARMACOLOGICAL RESEARCH

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

(2015) Carlotta Giorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Mitochondrial Vulnerability and Increased Susceptibility to Nutrient-Induced Cytotoxicity in Fibroblasts from Leigh Syndrome French Canadian Patients

(2015) Yan Burelle et al.   PLoS One

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

(2015) Carlotta Giorgi et al.   Oncotarget

Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance

(2014) Gerald Pfeffer et al.   BRAIN

HIF-1 reduces ischaemia–reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

(2014) Sang-Ging Ong et al.   CARDIOVASCULAR RESEARCH

Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

(2014) Antonella Papa et al.   CELL

Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process

(2014) M Bonora et al.   CELL DEATH AND DIFFERENTIATION

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results

(2014) D. Atar et al.   EUROPEAN HEART JOURNAL

Regulation of the Mitochondrial Permeability Transition Pore by the Outer Membrane Does Not Involve the Peripheral Benzodiazepine Receptor (Translocator Protein of 18 kDa (TSPO))

(2014) Justina Šileikytė et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocation of Glycogen Synthase Kinase-3β (GSK-3β), a Trigger of Permeability Transition, Is Kinase Activity-dependent and Mediated by Interaction with Voltage-dependent Anion Channel 2 (VDAC2)

(2014) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure Based Design, Synthesis, Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Identification of Novel Cyclophilin D Inhibitors

(2014) Koteswara Rao Valasani et al.   Journal of Chemical Information and Modeling

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition

(2014) M Bonora et al.   ONCOGENE

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis

(2014) Lee J. Martin et al.   Frontiers in Cellular Neuroscience

Chaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15

(2014) D Sinha et al.   Cell Death & Disease

The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death

(2014) Massimo Bonora et al.   Frontiers in Oncology

PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy

(2013) Simone Patergnani et al.   Autophagy

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

Redox-sensitive glycogen synthase kinase 3β-directed control of mitochondrial permeability transition: rheostatic regulation of acute kidney injury

(2013) Zhen Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.

(2013) Robert J. Wong et al.   HEPATOLOGY

Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy

(2013) Jean Giacomotto et al.   HUMAN MOLECULAR GENETICS

How Parkinsonian Toxins Dysregulate the Autophagy Machinery

(2013) Ruben Dagda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model

(2013) Hong Xie et al.   JOURNAL OF NEUROSCIENCE

The role of the mitochondrial calcium uniporter in cerebral ischemia/reperfusion injury in rats involves regulation of mitochondrial energy metabolism

(2013) QIN ZHAO et al.   Molecular Medicine Reports

Mitochondrial Complex Enzyme Activities and Cytochrome c Expression Changes in Multiple Sclerosis

(2013) Pedro Iñarrea et al.   MOLECULAR NEUROBIOLOGY

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1−42 on neural progenitor cell proliferation

(2013) Yan Hou et al.   NEUROBIOLOGY OF AGING

H-Ras-driven tumoral maintenance is sustained through caveolin-1-dependent alterations in calcium signaling

(2013) A Rimessi et al.   ONCOGENE

The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration

(2013) Costanza Savino et al.   Oxidative Medicine and Cellular Longevity

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Mitochondrial dysfunction and neurodegeneration in multiple sclerosis

(2013) Kimmy Su et al.   Frontiers in Physiology

Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members

(2012) Denise Tischner et al.   APOPTOSIS

Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

(2012) Jerome Piquereau et al.   CARDIOVASCULAR RESEARCH

Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis

(2012) Kimmy G. Su et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

A Mitochondrial Permeability Transition Pore Inhibitor Improves Renal Outcomes After Revascularization in Experimental Atherosclerotic Renal Artery Stenosis

(2012) Alfonso Eirin et al.   HYPERTENSION

Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein

(2012) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury

(2012) Hao Bao et al.   KIDNEY INTERNATIONAL

Regulation of mitochondrial permeability transition pore by PINK1

(2012) Clement A Gautier et al.   Molecular Neurodegeneration

Programmed necrosis in acute kidney injury

(2012) A. Linkermann et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

(2012) Emilie Giaime et al.   PLoS One

Autophagy as a new therapeutic target in Duchenne muscular dystrophy

(2012) C De Palma et al.   Cell Death & Disease

Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis

(2012) S Marchi et al.   Cell Death & Disease

Skeletal Muscle Degenerative Diseases and Strategies for Therapeutic Muscle Repair

(2011) Mohammadsharif Tabebordbar et al.   Annual Review of Pathology-Mechanisms of Disease

The role of mitochondrial permeability transition in reperfusion-induced cardiomyocyte death depends on the duration of ischemia

(2011) Marisol Ruiz-Meana et al.   BASIC RESEARCH IN CARDIOLOGY

Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells

(2011) Tao Cui et al.   BRAIN RESEARCH

Liver mitochondrial function and redox status in an experimental model of non-alcoholic fatty liver disease induced by monosodium l-glutamate in rats

(2011) Murilo de Oliveira Lazarin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts

(2011) David Cotán et al.   FASEB JOURNAL

α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator

(2011) Yuangang Zhu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of Amyloid-  (A ) Peptide-Binding Alcohol Dehydrogenase-A  Interaction Reduces A  Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease

(2011) J. Yao et al.   JOURNAL OF NEUROSCIENCE

Requirement of FADD, NEMO, and BAX/BAK for Aberrant Mitochondrial Function in Tumor Necrosis Factor Alpha-Induced Necrosis

(2011) K. M. Irrinki et al.   MOLECULAR AND CELLULAR BIOLOGY

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

MAP4 Mechanism that Stabilizes Mitochondrial Permeability Transition in Hypoxia: Microtubule Enhancement and DYNLT1 Interaction with VDAC1

(2011) Ya-dong Fang et al.   PLoS One

Cyclosporine A attenuates hypoxic–ischemic brain injury in newborn rats

(2010) Jong Hee Hwang et al.   BRAIN RESEARCH

Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells

(2010) J. C. Ghosh et al.   CANCER RESEARCH

TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition

(2010) S. Schaller et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice

(2009) Lee J. Martin et al.   EXPERIMENTAL NEUROLOGY

Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

(2009) Amalia Gastaldelli et al.   HEPATOLOGY

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

(2009) Elena Palma et al.   HUMAN MOLECULAR GENETICS

Reversible Cyclosporin A-sensitive Mitochondrial Depolarization Occurs within Minutes of Stroke Onset in Mouse Somatosensory Cortexin Vivo

(2009) Ran R. Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

(2009) Guangwei Liu et al.   NEUROSCIENCE LETTERS

Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli

(2008) Saverio Marchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A peptide containing residues 26–44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator

(2008) A. Atlante et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial defects in acute multiple sclerosis lesions

(2008) Don Mahad et al.   BRAIN

Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy

(2008) J Reutenauer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression

(2008) João S. Teodoro et al.   MITOCHONDRION

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

(2008) Douglas P Millay et al.   NATURE MEDICINE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Autosomal recessive myosclerosis myopathy is a collagen VI disorder

(2008) L. Merlini et al.   NEUROLOGY