Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

(2015) Andrew P. Halestrap et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Traumatic brain injury-induced axonal phenotypes react differently to treatment

(2014) Anders Hånell et al.   ACTA NEUROPATHOLOGICA

The central role of mitochondria in axonal degeneration in multiple sclerosis

(2014) Graham R Campbell et al.   Multiple Sclerosis Journal

Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons

(2014) Nobuhiko Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution crystal structures of two crystal forms of human cyclophilin D in complex with PEG 400 molecules

(2014) Koteswara Rao Valasani et al.   Acta Crystallographica Section F-Structural Biology Communications

P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain

(2013) Carolyn M. Porteous et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis

(2013) Sarah Al-Izki et al.   BRAIN

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists

(2013) Gareth Pryce et al.   FASEB JOURNAL

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

(2013) Rodrigo A Quintanilla et al.   Molecular Neurodegeneration

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration

(2013) Costanza Savino et al.   Oxidative Medicine and Cellular Longevity

PharmGKB summary

(2013) Julia M. Barbarino et al.   Pharmacogenetics and Genomics

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profile of alisporivir and its potential in the treatment of hepatitis C

(2013) Philippe Gallay et al.   Drug Design Development and Therapy

No evidence for a local renin-angiotensin system in liver mitochondria

(2013) Ronan Astin et al.   Scientific Reports

Mitochondrial dysfunction and neurodegeneration in multiple sclerosis

(2013) Kimmy Su et al.   Frontiers in Physiology

Mitochondrially targeted compounds and their impact on cellular bioenergetics

(2013) Colin Reily et al.   Redox Biology

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis

(2013) David W Hampton et al.   Acta Neuropathologica Communications

Disease Modifying Drugs in Multiple Sclerosis: Mechanisms of Action and New Drugs in the Horizon

(2012) Monica Marta et al.   CNS & Neurological Disorders-Drug Targets

Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis

(2012) Kimmy G. Su et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Combination of cyclosporine A with corticosteroids is effective for the treatment of neuromyelitis optica

(2012) Takashi Kageyama et al.   JOURNAL OF NEUROLOGY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes

(2011) Henry Dube et al.   BIOCHEMICAL JOURNAL

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels

(2011) Christos Chinopoulos et al.   FEBS Journal

Yin and Yang in medicinal chemistry: what does drug-likeness mean?

(2011) Ricardo Macarrón et al.   Future Medicinal Chemistry

Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore

(2011) S. A. Barrientos et al.   JOURNAL OF NEUROSCIENCE

Post-Injury Administration of the Mitochondrial Permeability Transition Pore Inhibitor, NIM811, Is Neuroprotective and Improves Cognition after Traumatic Brain Injury in Rats

(2011) Ryan D. Readnower et al.   JOURNAL OF NEUROTRAUMA

Critical appraisal of animal models of multiple sclerosis

(2011) David Baker et al.   Multiple Sclerosis Journal

Practical guide to the induction of relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse

(2011) Sarah Al-Izki et al.   Multiple Sclerosis and Related Disorders

The Mitochondrial Antioxidants MitoE2 and MitoQ10 Increase Mitochondrial Ca2+ Load upon Cell Stimulation by Inhibiting Ca2+ Efflux from the Organelle

(2010) Sara Leo et al.   Annals of the New York Academy of Sciences

Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure

(2010) Shiang Y. Lim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

(2010) Edward J. Gane et al.   LIVER INTERNATIONAL

Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity

(2010) Melissa Millard et al.   PLoS One

Facile Synthesis of a Fluorescent Cyclosporin A Analogue To Study Cyclophilin 40 and Cyclophilin 18 Ligands

(2010) Steffen Gaali et al.   ACS Medicinal Chemistry Letters

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

(2010) Tara L. Davis et al.   PLOS BIOLOGY

Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

(2010) Laura M. J. Ylinen et al.   PLoS Pathogens

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

(2009) Sylvanie Malouitre et al.   BIOCHEMICAL JOURNAL

The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging

(2009) Masashi Kato et al.   CARDIOVASCULAR RESEARCH

The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice

(2009) Lee J. Martin et al.   EXPERIMENTAL NEUROLOGY

Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex

(2009) Valentina Giorgio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of Myelin and Axon Pathology During Relapsing Progressive Experimental Autoimmune Encephalomyelitis in the Biozzi ABH Mouse

(2009) Samuel J. Jackson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Truncation of TRIM5 in the Feliformia Explains the Absence of Retroviral Restriction in Cells of the Domestic Cat

(2009) W. A. McEwan et al.   JOURNAL OF VIROLOGY

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Targeting Mitochondria

(2008) Adam T. Hoye et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mitochondrial defects in acute multiple sclerosis lesions

(2008) Don Mahad et al.   BRAIN

Phosphate Is Essential for Inhibition of the Mitochondrial Permeability Transition Pore by Cyclosporin A and by Cyclophilin D Ablation

(2008) Emy Basso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclophilin D is expressed predominantly in mitochondria of γ-aminobutyric acidergic interneurons

(2008) Julie L. Hazelton et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog

(2007) L.H. Mbye et al.   EXPERIMENTAL NEUROLOGY

Analysis of liver function in renal transplant recipients undergoing C2-monitoring for cyclosporine

(2007) Manfred Hecking et al.   TRANSPLANT INTERNATIONAL