期刊
PHARMACOLOGICAL RESEARCH
卷 99, 期 -, 页码 82-85出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2015.05.008
关键词
p53; Intravital imaging; Cell death and apoptosis; Cancer; Calcium signaling
资金
- Italian Association for Cancer Research (AIRC)
- Telethon [GGP11139B]
- University of Ferrara
- Italian Ministry of Education, University and Research (COFIN)
- Italian Ministry of Education, University and Research (FIRB)
- Italian Ministry of Education, University and Research (Futuro in Ricerca)
Intracellular calcium (Ca2+) is largely known as a second messenger that is able to drive effects ranging from vesicle formation to muscle contraction, energy production and much more. In spite of its physiological regulation, Ca2+ is a strategic tool for regulating apoptosis, especially during transmission between the endoplasmic reticulum and the mitochondria. Contact sites between these organelles are well-defined as signaling platforms where oncogenes and oncosuppressors can exert anti/pro-apoptotic activities. Recent advances from in vivo investigations into these regions highlight the role of the master oncosuppressor p53 in regulating Ca2+ transmission and apoptosis, and we propose that Ca2+ signals are relevant targets when developing new therapeutic approaches. (C) 2015 Elsevier Ltd. All rights reserved.
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