Article
Genetics & Heredity
Mbarka Bchetnia, Jessica Tardif, Charles Morin, Catherine Laprise
Summary: By analyzing the transcriptomes of LSFC cell lines and healthy cell lines, this study identified altered biological pathways in Leigh syndrome, French-Canadian type (LSFC) and found that genes involved in the mitochondrial respiratory chain and energy production were the most important potential factors in this disease.
MOLECULAR GENETICS AND METABOLISM REPORTS
(2022)
Article
Pediatrics
Osama Y. Muthaffar, Angham Abdulrhman Abdulkareem, Abrar Ashi, Muhammad Imran Naseer
Summary: This study identified a novel variant in the LRPPRC gene in a family with Leigh syndrome-like phenotype. Whole exome sequencing and Sanger sequencing confirmed the pathogenicity of this variant. The findings suggest that WES can be used as a first-line diagnostic tool for familial cases and help resolve unresolved molecular diagnoses.
FRONTIERS IN PEDIATRICS
(2023)
Article
Plant Sciences
Lucas Deschamps, Vincent Maire, Lin Chen, Daniel Fortier, Gilles Gauthier, Amelie Morneault, Elisabeth Hardy-Lachance, Isabelle Dalcher-Gosselin, Francois Tanguay, Charles Gignac, Jeffrey M. McKenzie, Line Rochefort, Esther Levesque
Summary: Understanding the feedbacks caused by the release of carbon stored in permafrost and the direct impacts of climate variations on permafrost dynamics is crucial. Indirect effects of global change, such as changes in soil nutrient availability and grazing pressure, can also impact soil properties and heat transfer in the Arctic tundra, affecting the resilience of Arctic ecosystems.
JOURNAL OF ECOLOGY
(2023)
Article
Multidisciplinary Sciences
Fanny Girard, Sidonie Catteau, Delphine Gambaiani, Olivia Gerigny, Jean Baptiste Senegas, Pierre Moisson, Francoise Claro
Summary: Climate-induced environmental changes have led to significant impacts on marine ecosystems and altered species distribution, particularly for migratory organisms like sea turtles. A study in the French Mediterranean over the past 30 years showed a notable increase in the size and reproductive activity of loggerhead turtles, especially during the breeding season. Evidence suggests that the north-western Mediterranean basin has become more suitable for loggerhead turtles as a result of climate change.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Seung-Il Choi, Ga-Hyun Lee, Jong-Hwan Woo, Ikhyun Jun, Eung Kweon Kim
Summary: The imbalance of mitochondrial dynamics may be a critical mechanism leading to mitochondrial dysfunction in GCD2 corneal fibroblasts.
Article
Biotechnology & Applied Microbiology
Ameer A. Imarah, Majid S. Jabir, Ali H. Abood, Ghassan M. Sulaiman, Salim Albukhaty, Hamdoon A. Mohammed, Riaz A. Khan, Hayder M. Al-Kuraishy, Ali Al-Gareeb, Waleed K. Al-Azzawi, Mazin A. Najm, Sabrean F. Jawad
Summary: In this study, the cytotoxic effects of graphene oxide nanoparticles (GONPs) were evaluated using MTT assays, observation of apoptotic markers, and oxidative stress. Significant cytotoxic and apoptotic effects were observed. Analyses of CYP2E1 and malondialdehyde concentrations confirmed the toxicity of GONPs, while the levels of glutathione showed a reduction compared to the control. The alterations in cytochrome CYP2E1, glutathione, malondialdehyde, and caspase-3 suggest an interlinked relationship.
Article
Pediatrics
Anil Kumar Poonia, Suchitra Garhwal, Anupam Chaturvedi
Summary: LSFC is a neurological disorder with various symptoms, while leprechaunism is characterized by persistent hyperglycemia due to extreme insulin resistance. This unique case presents the association of leprechaunism as the initial presentation in LSFC, which has not been documented in literature before.
JOURNAL OF CLINICAL NEONATOLOGY
(2021)
Article
Oncology
Konrad Wrobel, Stanislaw Wolowiec, Joanna Markowicz, Elzbieta Walajtys-Rode, Lukasz Uram
Summary: New anti-cancer drugs can be created by combining well-known substances acting on different molecular targets. In this study, two known anti-glioma drugs were linked to a specific carrier, resulting in a more potent effect than using the drugs alone.
Article
Cell Biology
Yvette Mukaneza, Aaron Cohen, Marie-Eve Rivard, Jessica Tardif, Sonia Deschenes, Matthieu Ruiz, Catherine Laprise, Christine Des Rosiers, Lise Coderre, Bruce G. Allen, Claudine Beauchamp, Chantal Bemeur, Yan Burelle, Guy Charron, Francois Labarthe, Jeannine Landry, Genevieve Lavallee, Pierre Lavoie, Sylvie Lesage, Bruno Maranda, Charles Morin, John D. Rioux, Eric A. Shoubridge, Julie Thompson Legault, Nancy Tremblay, Vanessa Tremblay-Vaillancourt, Luc Vachon, Josee Villeneuve
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Sukhpreet Tamana, Victor Ezeugwu, Joyce Chikuma, Diana Lefebvre, Meghan Azad, Theo Moraes, Padmaja Subbarao, Allan Becker, Stuart Turvey, Malcolm Sears, Bruce Dick, Valerie Carson, Carmen Rasmussen, Jacqueline Pei, Piush Mandhane
Article
Allergy
Pierre-Emmanuel Sugier, Chloe Sarnowski, Raquel Granell, Catherine Laprise, Markus J. Ege, Patricia Margaritte-Jeannin, Marie-Helene Dizier, Cosetta Minelli, Miriam F. Moffatt, Mark Lathrop, William O. C. M. Cookson, A. John Henderson, Erika von Mutius, Manolis Kogevinas, Florence Demenais, Emmanuelle Bouzigon
CLINICAL AND EXPERIMENTAL ALLERGY
(2019)
Article
Physiology
Hashim Islam, Andrew Ma, Alessandra Amato, Alexanne Cuillerier, Yan Burelle, Craig A. Simpson, Joe Quadrilatero, Brendon J. Gurd
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2020)
Article
Cell Biology
Ujval Anilkumar, Mireille Khacho, Alexanne Cuillerier, Richard Harris, David A. Patten, Maria Bilen, Mohamed Ariff Iqbal, Ding Yuan Guo, Louis-Eric Trudeau, David S. Park, Mary-Ellen Harper, Yan Burelle, Ruth S. Slack
CELL DEATH & DISEASE
(2020)
Article
Physiology
Thomas Dupas, Manon Denis, Justine Dontaine, Antoine Persello, Laurent Bultot, Angelique Erraud, Didier Vertommen, Bertrand Bouchard, Arnaud Tessier, Matthieu Riviere, Jacques Lebreton, Edith Bigot-Corbel, Jerome Montnach, Michel De Waard, Chantal Gauthier, Yan Burelle, Aaron K. Olson, Bertrand Rozec, Christine Des Rosiers, Luc Bertrand, Tarik Issad, Benjamin Lauzier
Summary: The study found that protein O-GlcNAc levels decrease significantly and progressively from birth to adulthood in the heart, while the changes in liver and brain are opposite. O-GlcNAc levels are minimally affected by weaning diet, and changes in regulatory enzymes and metabolites levels are tissue-specific. Mass spectrometry identified potential O-GlcNAcylated proteins in the heart, suggesting a specific role for these proteins in the development process.
Review
Nutrition & Dietetics
Frederic N. Daussin, Elsa Heyman, Yan Burelle
Summary: This article discusses the effects of (-)-epicatechin on mitochondria, summarizes the impact of acute and chronic supplementation of (-)-epicatechin on mitochondrial function, and explores potential future therapeutic applications.
Article
Biochemistry & Molecular Biology
Emile Belanger, Anne-Marie Madore, Anne-Marie Boucher-Lafleur, Marie-Michelle Simon, Tony Kwan, Tomi Pastinen, Catherine Laprise
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biology
George Cairns, Madhavee Thumiah-Mootoo, Yan Burelle, Mireille Khacho
Article
Gastroenterology & Hepatology
Gabrielle Boucher, Alexandre Paradis, Genevieve Chabot-Roy, Lise Coderre, Erin E. Hillhouse, Alain Bitton, Christine Des Rosiers, Megan K. Levings, L. Philip Schumm, Mark Lazarev, Steve R. Brant, Richard Duerr, Dermot McGovern, Mark S. Silverberg, Judy Cho, Sylvie Lesage, John D. Rioux
Summary: This study identified elevated levels of multiple serum analytes in Crohn's disease (CD) patients, implicating multiple cell types from the immune, epithelial, and endothelial systems. These circulating analytes reflect the ongoing inflammatory processes within the gut. Furthermore, distinct profiles according to disease location support the biological difference between ileal and colonic CD, consistent with previous genetic and clinical observations.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Emile Belanger, Catherine Laprise
Summary: Epigenetics is a study of changes in gene expression influenced by environment or social factors, involving mechanisms such as DNA methylation, histone modification, and noncoding RNA. Understanding epigenetic mechanisms in human diseases provides valuable insights into disease severity and development. Research on the regulation of allergies and asthma through epigenetic mechanisms, particularly using eosinophil samples, is limited, but can enhance understanding of eosinophil recruitment in allergic and asthmatic symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Lise Coderre, Lyna Debieche, Joelle Plourde, Remi Rabasa-Lhoret, Sylvie Lesage
Summary: Cystic fibrosis-related diabetes (CFRD) is a common comorbidity in cystic fibrosis patients, with a prevalence of over 50% in adults. The etiology of CFRD is not fully understood, but research suggests it may result from beta-cell extrinsic factors. Inflammation and ductal cells near beta-cells could play a role in CFRD development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Alexanne Cuillerier, Matthieu Ruiz, Caroline Daneault, Anik Forest, Jenna Rossi, Goutham Vasam, George Cairns, Virgilio Cadete, Christine Des Rosiers, Yan Burelle
Summary: This study investigates compensatory mechanisms in mice with liver-specific knockout of LRPPRC, revealing a network of molecular adjustments, including mitochondrial biogenesis, mitoribosome upregulation, and supercomplex assembly, to maintain mitochondrial integrity and function in the face of OXPHOS defects. Despite a severe reduction in ETC complex IV activity, these mice show no signs of liver failure, suggesting the presence of proteostatic mechanisms and supercomplex stabilization as key factors in preserving ETC function under low LRPPRC levels.
COMMUNICATIONS BIOLOGY
(2021)
Article
Microbiology
William Bourumeau, Karine Tremblay, Guillaume Jourdan, Catherine Girard, Catherine Laprise
Summary: This study finds that COVID-19 infection leads to dysbiosis in the upper respiratory tract, and identifies different biomarkers for positive and negative-tested individuals. These findings suggest that individuals with prior dysbiosis may have a higher risk of opportunistic pathogen infections.
Meeting Abstract
Critical Care Medicine
V. Cadete, J. Zelt, A. Cuillerier, Y. Deng, K. Rowe, L. Mielniczuk, Y. Burelle, D. J. Stewart
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)