OPA1 processing in cell death and disease – the long and short of it

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria

(2016) Anne Korwitz et al.   JOURNAL OF CELL BIOLOGY

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

(2016) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

(2016) A.M. Bertholet et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress

(2016) T. Kelly Rainbolt et al.   Cell Reports

Syndromic parkinsonism and dementia associated withOPA1missense mutations

(2015) Valerio Carelli et al.   ANNALS OF NEUROLOGY

Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration

(2015) Y Qi et al.   CELL DEATH AND DIFFERENTIATION

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart

(2015) Moshi Song et al.   Cell Metabolism

Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization

(2015) Prashant Mishra et al.   Cell Metabolism

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

(2015) Gabriele Civiletto et al.   Cell Metabolism

Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness

(2015) Uwe Richter et al.   JOURNAL OF CELL BIOLOGY

Fatal infantile mitochondrial encephalomyopathy, hypertrophic cardiomyopathy and optic atrophy associated with a homozygousOPA1mutation

(2015) Ronen Spiegel et al.   JOURNAL OF MEDICAL GENETICS

Mitochondrial Genome Maintenance 1 (Mgm1) Protein Alters Membrane Topology and Promotes Local Membrane Bending

(2015) Jarungjit Rujiviphat et al.   JOURNAL OF MOLECULAR BIOLOGY

Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration

(2015) Yue Sun et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

(2015) Julien Prudent et al.   MOLECULAR CELL

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

(2015) Wei-ke Ji et al.   eLife

Determinants and Functions of Mitochondrial Behavior

(2014) Katherine Labbé et al.   Annual Review of Cell and Developmental Biology

DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling

(2014) Ricarda Richter-Dennerlein et al.   Cell Metabolism

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

(2014) Prashant Mishra et al.   Cell Metabolism

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

(2014) D. A. Patten et al.   EMBO JOURNAL

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

(2014) M. J. Baker et al.   EMBO JOURNAL

Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage

(2014) K. Zhang et al.   EMBO REPORTS

YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress

(2014) T. K. Rainbolt et al.   EMBO REPORTS

Stress-triggered Activation of the Metalloprotease Oma1 Involves Its C-terminal Region and Is Important for Mitochondrial Stress Protection in Yeast

(2014) Iryna Bohovych et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission

(2014) Sunan Li et al.   JOURNAL OF CELL BIOLOGY

Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation

(2014) Thomas D. B. MacVicar et al.   JOURNAL OF CELL SCIENCE

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondriacristaeand ER contacts in the postprandial liver

(2014) Aditi Sood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis

(2014) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROMO1 Is an Essential Redox-Dependent Regulator of Mitochondrial Dynamics

(2014) M. Norton et al.   Science Signaling

Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate

(2014) X Wang et al.   Cell Death & Disease

New insights into the function and regulation of mitochondrial fission

(2013) Hidenori Otera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Adaptor Proteins MiD49 and MiD51 Can Act Independently of Mff and Fis1 in Drp1 Recruitment and Are Specific for Mitochondrial Fission

(2013) Catherine S. Palmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria

(2013) H.-J. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Loss of Yme1L perturbates mitochondrial dynamics

(2013) Y Ruan et al.   Cell Death & Disease

OPA1 Mutation and Late‐Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability

(2013) Le Chen et al.   Journal of the American Heart Association

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

(2012) Pedro M Quirós et al.   EMBO JOURNAL

YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation

(2012) Lukas Stiburek et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

(2012) Carsten Merkwirth et al.   PLoS Genetics

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

(2010) Veronica Costa et al.   EMBO Molecular Medicine

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion

(2009) Michael Zick et al.   FEBS LETTERS

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion

(2009) Rachel M. DeVay et al.   JOURNAL OF CELL BIOLOGY

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

(2009) Brian Head et al.   JOURNAL OF CELL BIOLOGY

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

(2008) C. Merkwirth et al.   GENES & DEVELOPMENT

Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization

(2008) Ryuji Yamaguchi et al.   MOLECULAR CELL