Inflammasome activation and regulation: toward a better understanding of complex mechanisms
出版年份 2020 全文链接
标题
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
作者
关键词
-
出版物
Cell Discovery
Volume 6, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-06-09
DOI
10.1038/s41421-020-0167-x
参考文献
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- Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly
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- Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation
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- NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease
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- Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
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- Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
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- Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
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- IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
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- Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection
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- Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
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- Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1
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- Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism
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- Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
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- Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
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- Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation
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- Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor
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- The mammalian PYHIN gene family: Phylogeny, evolution and expression
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- TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria
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- NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens
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- Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice
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- The NLRP12 Inflammasome Recognizes Yersinia pestis
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- An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages
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- NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling
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- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
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- Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor
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- Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP
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- Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
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- Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin
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- Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity
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- NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223
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- Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
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- Inflammasomes in health and disease
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- NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens
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- Phosphorylation of NLRC4 is critical for inflammasome activation
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- The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
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- Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β
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- The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB
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- Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
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- NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis
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- Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
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- Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome
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- Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome
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- NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
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- IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
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- The NLRP3 inflammasome in health and disease: the good, the bad and the ugly
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- A clinical perspective of IL-1β as the gatekeeper of inflammation
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- Immune Signaling by RIG-I-like Receptors
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- NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK
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- A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis
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- Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
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- The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
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- Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
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- Non-canonical inflammasome activation targets caspase-11
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- Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
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- Human NLRP3 inflammasome activation is Nox1-4 independent
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- The Inflammasomes
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- NLRC5 Limits the Activation of Inflammatory Pathways
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- Cutting Edge: NLRC5-Dependent Activation of the Inflammasome
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- NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
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- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
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- The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
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- The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
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- Influenza virus activates inflammasomes via its intracellular M2 ion channel
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- Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
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- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
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- The Inflammasomes: Guardians of the Body
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- Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
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- Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
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- Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region
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- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
- (2009) Veit Hornung et al. NATURE
- Thioredoxin-interacting protein links oxidative stress to inflammasome activation
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- HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA
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- The NLR Gene Family: A Standard Nomenclature
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- NLRX1 is a regulator of mitochondrial antiviral immunity
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- Origin and physiological roles of inflammation
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- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
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- Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
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