NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Real-time resolution of point mutations that cause phenovariance in mice

(2015) Tao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

(2014) A. Orthwein et al.   SCIENCE

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

(2012) Vincent Compan et al.   IMMUNITY

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5

(2011) M Teresa Bertran et al.   EMBO JOURNAL

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells

(2011) S. Kim et al.   JOURNAL OF CELL SCIENCE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy

(2010) H Salem et al.   ONCOGENE

Mechanisms of interleukin-1β release

(2009) Claudia Eder   IMMUNOBIOLOGY

The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

(2009) L. O'Regan et al.   MOLECULAR AND CELLULAR BIOLOGY

Cellular responses to reactive oxygen species-induced DNA damage and aging

(2008) Catharina Bertram et al.   BIOLOGICAL CHEMISTRY