Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
出版年份 2013 全文链接
标题
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
作者
关键词
-
出版物
NATURE MEDICINE
Volume 19, Issue 9, Pages 1132-1140
出版商
Springer Nature
发表日期
2013-08-19
DOI
10.1038/nm.3265
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Chronic Endocannabinoid System Stimulation Induces Muscle Macrophage and Lipid Accumulation in Type 2 Diabetic Mice Independently of Metabolic Endotoxaemia
- (2013) Lucie Geurts et al. PLoS One
- JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities
- (2012) Robert J. Chorvat et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production
- (2012) Arya E. Mehran et al. Cell Metabolism
- Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance
- (2012) Joseph Tam et al. Cell Metabolism
- Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome
- (2012) Christine M. Oslowski et al. Cell Metabolism
- IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
- (2012) Alana G. Lerner et al. Cell Metabolism
- Chronic activation of cannabinoid receptorsin vitrodoes not compromise mouse islet function
- (2012) Alonso Vilches-Flores et al. CLINICAL SCIENCE
- Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes
- (2012) Hye-Mi Lee et al. DIABETES
- Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight
- (2012) K. Rohrbach et al. DIABETES OBESITY & METABOLISM
- Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice
- (2012) Jie Liu et al. GASTROENTEROLOGY
- Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans
- (2012) Gijs H. Goossens et al. MOLECULAR IMMUNOLOGY
- The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
- (2012) Geun-Shik Lee et al. NATURE
- Beneficial Metabolic Effects of CB1R Anti-Sense Oligonucleotide Treatment in Diet-Induced Obese AKR/J Mice
- (2012) Yuting Tang et al. PLoS One
- Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids
- (2012) Dmitry Grapov et al. PLoS One
- JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
- (2012) M. S. Han et al. SCIENCE
- Cannabinoids Induce Pancreatic -Cell Death by Directly Inhibiting Insulin Receptor Activation
- (2012) W. Kim et al. Science Signaling
- Glucan particles for selective delivery of siRNA to phagocytic cells in mice
- (2011) Gregory J. Tesz et al. BIOCHEMICAL JOURNAL
- Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis
- (2011) J. D. O'Hare et al. DIABETES
- Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion
- (2011) M. A. Osundiji et al. DIABETES
- Hyperuricemia as a Mediator of the Proinflammatory Endocrine Imbalance in the Adipose Tissue in a Murine Model of the Metabolic Syndrome
- (2011) W. Baldwin et al. DIABETES
- Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic -Cells
- (2011) W. Kim et al. DIABETES
- Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage
- (2011) Yun-Hee Youm et al. ENDOCRINOLOGY
- Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice
- (2011) Alexandre Louvet et al. HEPATOLOGY
- Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: Evidence from cultured explants
- (2011) Tony Jourdan et al. HEPATOLOGY
- Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function
- (2011) Vivian C. Calegari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver
- (2011) B. Mukhopadhyay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
- The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
- (2010) Rinke Stienstra et al. Cell Metabolism
- Inhibitor of Fatty Acid Amide Hydrolase Normalizes Cardiovascular Function in Hypertension without Adverse Metabolic Effects
- (2010) Grzegorz Godlewski et al. CHEMISTRY & BIOLOGY
- CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice
- (2010) T. Jourdan et al. DIABETES
- Transcriptional Regulation of Cannabinoid Receptor-1 Expression in the Liver by Retinoic Acid Acting via Retinoic Acid Receptor-γ
- (2010) Bani Mukhopadhyay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
- (2010) Joseph Tam et al. JOURNAL OF CLINICAL INVESTIGATION
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
- (2010) Seth L Masters et al. NATURE IMMUNOLOGY
- CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages
- (2009) K. H. Han et al. CARDIOVASCULAR RESEARCH
- From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
- (2009) R. A. DeFronzo DIABETES
- Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
- (2009) Myriam Aouadi et al. NATURE
- Thioredoxin-interacting protein links oxidative stress to inflammasome activation
- (2009) Rongbin Zhou et al. NATURE IMMUNOLOGY
- The future of endocannabinoid-oriented clinical research after CB1 antagonists
- (2009) Bernard Le Foll et al. PSYCHOPHARMACOLOGY
- The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake
- (2008) Carol Addy et al. Cell Metabolism
- SERENADE: The Study Evaluating Rimonabant Efficacy in Drug-Naive Diabetic Patients: Effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes
- (2008) J. Rosenstock et al. DIABETES CARE
- Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle
- (2008) K. Eckardt et al. DIABETOLOGIA
- Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet
- (2008) Katarzyna M. Starowicz et al. Obesity
- Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
- (2008) C. Dostert et al. SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started