The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

(2018) Apurva Kanneganti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Monosodium Urate Crystals Generate Nuclease-Resistant Neutrophil Extracellular Traps via a Distinct Molecular Pathway

(2018) Simon M. Chatfield et al.   JOURNAL OF IMMUNOLOGY

Cholesterol Crystal-Mediated Inflammation Is Driven by Plasma Membrane Destabilization

(2018) Fei Shu et al.   Frontiers in Immunology

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

(2018) Congfei Xu et al.   Nature Communications

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

(2018) James E. Vince et al.   Cell Reports

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

(2018) Jianqiu Xiao et al.   PLOS BIOLOGY

Inflammatory Potential of Four Different Phases of Calcium Pyrophosphate Relies on NF-κB Activation and MAPK Pathways

(2018) Laure Campillo-Gimenez et al.   Frontiers in Immunology

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D

(2017) Kimberley D. Gutierrez et al.   JOURNAL OF IMMUNOLOGY

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation

(2017) Gregory M. Orlowski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammation in gout: mechanisms and therapeutic targets

(2017) Alexander K. So et al.   Nature Reviews Rheumatology

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

(2017) Siyun Kuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin

(2017) Jyaysi Desai et al.   Scientific Reports

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

Crystal Formation in Inflammation

(2016) Bernardo S. Franklin et al.   Annual Review of Immunology

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion

(2016) S A Conos et al.   CELL DEATH AND DIFFERENTIATION

The role of glycine in regulated cell death

(2016) Joel M. Weinberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Crystallopathies

(2016) Shrikant R. Mulay et al.   NEW ENGLAND JOURNAL OF MEDICINE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

(2016) Shrikant R. Mulay et al.   Nature Communications

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

(2015) Jürgen Brojatsch et al.   CELL CYCLE

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

(2015) Jyaysi Desai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

(2015) Gregory M. Orlowski et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Global epidemiology of gout: prevalence, incidence and risk factors

(2015) Chang-Fu Kuo et al.   Nature Reviews Rheumatology

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

Contribution of Mast Cell-Derived Interleukin-1β to Uric Acid Crystal-Induced Acute Arthritis in Mice

(2014) Laurent L. Reber et al.   Arthritis & Rheumatology

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

(2013) Heriberto Lima Jr. et al.   CELL CYCLE

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1  Secretion through the NLRP3 Inflammasome In Vitro

(2011) B. Pazar et al.   JOURNAL OF IMMUNOLOGY

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study

(2010) Alexander So et al.   ARTHRITIS AND RHEUMATISM

Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

(2010) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Interleukin-1β activation during acute joint inflammation: A limited role for the NLRP3 inflammasome in vivo

(2010) Leo A.B. Joosten et al.   JOINT BONE SPINE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Quality of Care in Patients with Gout: Why is Management Suboptimal and What Can Be Done About It?

(2010) N. Lawrence Edwards   Current Rheumatology Reports

Caspase 1–independent activation of interleukin-1β in neutrophil-predominant inflammation

(2009) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

(2009) T Vanden Berghe et al.   CELL DEATH AND DIFFERENTIATION

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE