The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology

Genome-wide association analysis of Parkinson’s disease and schizophrenia reveals shared genetic architecture and identifies novel risk loci

(2020) Olav B. Smeland et al.   BIOLOGICAL PSYCHIATRY

Genetic correlations between subcortical brain volumes and psychiatric disorders

(2020) Kazutaka Ohi et al.   BRITISH JOURNAL OF PSYCHIATRY

Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders

(2020) Shahram Bahrami et al.   JAMA Psychiatry

Making the MOSTest of Imaging Genetics

(2020) Dennis van der Meer et al.   BIOLOGICAL PSYCHIATRY

Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model

(2020) Dominic Holland et al.   PLoS Genetics

The Relationship Between Common Variant Schizophrenia Liability and Number of Offspring in the UK Biobank

(2019) Valentina Escott-Price et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence

(2019) Olav B Smeland et al.   MOLECULAR PSYCHIATRY

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

The Challenges and Opportunities of Small Effects

(2019) Martin P. Paulus et al.   JAMA Psychiatry

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Opportunities and challenges for transcriptome-wide association studies

(2019) Michael Wainberg et al.   NATURE GENETICS

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

(2019) Laura M. Huckins et al.   NATURE GENETICS

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

(2019) Patrick F. Sullivan et al.   CELL

Genome-wide association study identifies 30 loci associated with bipolar disorder

(2019) Eli A. Stahl et al.   NATURE GENETICS

Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits

(2019) Eric R. Gamazon et al.   NATURE GENETICS

Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk

(2019) Dag Alnæs et al.   JAMA Psychiatry

An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models

(2019) Josep Dalmau et al.   LANCET NEUROLOGY

Discovery of shared genomic loci using the conditional false discovery rate approach

(2019) Olav B. Smeland et al.   HUMAN GENETICS

A polygenic resilience score moderates the genetic risk for schizophrenia

(2019) Jonathan L. Hess et al.   MOLECULAR PSYCHIATRY

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

Synergistic effects of common schizophrenia risk variants

(2019) Nadine Schrode et al.   NATURE GENETICS

Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders

(2019) Tuomo Mäki-Marttunen et al.   Frontiers in Psychiatry

Comparative genetic architectures of schizophrenia in East Asian and European populations

(2019) Max Lam et al.   NATURE GENETICS

The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges

(2019) Olav B. Smeland et al.   PSYCHIATRIC GENETICS

Psychiatric Genomics: An Update and an Agenda

(2018) Patrick F. Sullivan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register

(2018) Rikke Hilker et al.   BIOLOGICAL PSYCHIATRY

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

(2018) Theo G.M. van Erp et al.   BIOLOGICAL PSYCHIATRY

The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis

(2018) Luis de la Torre-Ubieta et al.   CELL

Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model

(2018) Naomi R. Wray et al.   CELL

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

(2018) Douglas M. Ruderfer et al.   CELL

Psychiatric genetics and the structure of psychopathology

(2018) Jordan W. Smoller et al.   MOLECULAR PSYCHIATRY

Signatures of negative selection in the genetic architecture of human complex traits

(2018) Jian Zeng et al.   NATURE GENETICS

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

(2018) Jeanne E. Savage et al.   NATURE GENETICS

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

Convergence of placenta biology and genetic risk for schizophrenia

(2018) Gianluca Ursini et al.   NATURE MEDICINE

Psychotic Disorders

(2018) Jeffrey A. Lieberman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Re-evaluating classical body type theories: genetic correlation between psychiatric disorders and body mass index

(2018) Masashi Ikeda et al.   PSYCHOLOGICAL MEDICINE

Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016

(2018) Fiona J Charlson et al.   SCHIZOPHRENIA BULLETIN

Analysis of shared heritability in common disorders of the brain

(2018) et al.   SCIENCE

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

(2018) Michael J. Gandal et al.   SCIENCE

The Adolescent Brain Cognitive Development (ABCD) study: Imaging acquisition across 21 sites

(2018) B.J. Casey et al.   Developmental Cognitive Neuroscience

Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder

(2018) Judith Allardyce et al.   JAMA Psychiatry

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits

(2018) Yan Zhang et al.   NATURE GENETICS

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

(2018) Joëlle A. Pasman et al.   NATURE NEUROSCIENCE

SumHer better estimates the SNP heritability of complex traits from summary statistics

(2018) Doug Speed et al.   NATURE GENETICS

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

A Meta-analysis of Immune Parameters, Variability, and Assessment of Modal Distribution in Psychosis and Test of the Immune Subgroup Hypothesis

(2018) Toby Pillinger et al.   SCHIZOPHRENIA BULLETIN

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia

(2017) A Devor et al.   MOLECULAR PSYCHIATRY

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability

(2017) Tarjinder Singh et al.   NATURE GENETICS

Truncating mutations in RBM12 are associated with psychosis

(2017) Stacy Steinberg et al.   NATURE GENETICS

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

(2017) Zhiqiang Li et al.   NATURE GENETICS

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms

(2017) Olav B Smeland et al.   SCHIZOPHRENIA BULLETIN

Reproductive fitness and genetic risk of psychiatric disorders in the general population

(2017) Niamh Mullins et al.   Nature Communications

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

(2017) Russell L. McLaughlin et al.   Nature Communications

Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function

(2017) Olav B. Smeland et al.   JAMA Psychiatry

Identification of genetic loci shared between schizophrenia and the Big Five personality traits

(2017) Olav B. Smeland et al.   Scientific Reports

Genetic Markers of Human Evolution Are Enriched in Schizophrenia

(2016) Saurabh Srinivasan et al.   BIOLOGICAL PSYCHIATRY

Age-Dependent Pleiotropy Between General Cognitive Function and Major Psychiatric Disorders

(2016) W. David Hill et al.   BIOLOGICAL PSYCHIATRY

New statistical approaches exploit the polygenic architecture of schizophrenia—implications for the underlying neurobiology

(2016) Andrew J Schork et al.   CURRENT OPINION IN NEUROBIOLOGY

Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia

(2016) P H Lee et al.   MOLECULAR PSYCHIATRY

Genome-wide association study identifies 74 loci associated with educational attainment

(2016) Aysu Okbay et al.   NATURE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders

(2016) Min-Tzu Lo et al.   NATURE GENETICS

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

(2016) Christian R Marshall et al.   NATURE GENETICS

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

(2016) Tarjinder Singh et al.   NATURE NEUROSCIENCE

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

(2016) Barbara Franke et al.   NATURE NEUROSCIENCE

The road to precision psychiatry: translating genetics into disease mechanisms

(2016) Michael J Gandal et al.   NATURE NEUROSCIENCE

Gene expression elucidates functional impact of polygenic risk for schizophrenia

(2016) Menachem Fromer et al.   NATURE NEUROSCIENCE

Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia

(2016) Giulio Genovese et al.   NATURE NEUROSCIENCE

Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

(2015) Guillermo Gonzalez-Burgos et al.   BIOLOGICAL PSYCHIATRY

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

(2015) Tyrone D. Cannon et al.   BIOLOGICAL PSYCHIATRY

Specific and common genes implicated across major mental disorders: A review of meta-analysis studies

(2015) Justine M. Gatt et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Glutamate and dopamine in schizophrenia: An update for the 21st century

(2015) Oliver Howes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Genomic and Network Patterns of Schizophrenia Genetic Variation in Human Evolutionary Accelerated Regions

(2015) Ke Xu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Erratum: Identification of increased genetic risk scores for schizophrenia in treatment-resistant patients

(2015) J Frank et al.   MOLECULAR PSYCHIATRY

Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

(2015) T G M van Erp et al.   MOLECULAR PSYCHIATRY

Common genetic variants influence human subcortical brain structures

(2015) Derrek P. Hibar et al.   NATURE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

(2015) Robert A Power et al.   NATURE NEUROSCIENCE

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci

(2014) O A Andreassen et al.   MOLECULAR PSYCHIATRY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

A Role for Noncoding Variation in Schizophrenia

(2014) Panos Roussos et al.   Cell Reports

Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors

(2013) Ole A. Andreassen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Excess Early Mortality in Schizophrenia

(2013) Thomas Munk Laursen et al.   Annual Review of Clinical Psychology

Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010

(2013) Harvey A Whiteford et al.   LANCET

Schizophrenia: an integrated sociodevelopmental-cognitive model

(2013) Oliver D Howes et al.   LANCET

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies

(2013) P. Fusar-Poli et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs

(2013) Andrew J. Schork et al.   PLoS Genetics

Schizophrenia Is a Cognitive Illness

(2013) René S. Kahn et al.   JAMA Psychiatry

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

(2012) S.H. Lee et al.   BIOINFORMATICS

The Effects of Deleterious Mutations on Evolution at Linked Sites

(2012) Brian Charlesworth   GENETICS

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

(2012) S Hong Lee et al.   NATURE GENETICS

Dendritic spine pathology in schizophrenia

(2012) J.R. Glausier et al.   NEUROSCIENCE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brain Volumes in Schizophrenia: A Meta-Analysis in Over 18 000 Subjects

(2012) Sander V. Haijma et al.   SCHIZOPHRENIA BULLETIN

Childhood infection and adult schizophrenia: A meta-analysis of population-based studies

(2012) Golam M. Khandaker et al.   SCHIZOPHRENIA RESEARCH

Fecundity of Patients With Schizophrenia, Autism, Bipolar Disorder, Depression, Anorexia Nervosa, or Substance Abuse vs Their Unaffected Siblings

(2012) Robert A. Power et al.   JAMA Psychiatry

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Long-term Antipsychotic Treatment and Brain Volumes

(2011) Beng-Choon Ho et al.   ARCHIVES OF GENERAL PSYCHIATRY

Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects

(2011) Brian J. Miller et al.   BIOLOGICAL PSYCHIATRY

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Cost of disorders of the brain in Europe 2010

(2011) Anders Gustavsson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia

(2011) E S Lips et al.   MOLECULAR PSYCHIATRY

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

GABAergic interneuron origin of schizophrenia pathophysiology

(2011) Kazu Nakazawa et al.   NEUROPHARMACOLOGY

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

(2010) Alan S. Brown et al.   AMERICAN JOURNAL OF PSYCHIATRY

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

(2010) Thomas Insel et al.   AMERICAN JOURNAL OF PSYCHIATRY

Rethinking schizophrenia

(2010) Thomas R. Insel   NATURE

The environment and schizophrenia

(2010) Jim van Os et al.   NATURE

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

(2009) Paul Lichtenstein et al.   LANCET

Global pattern of experienced and anticipated discrimination against people with schizophrenia: a cross-sectional survey

(2009) Graham Thornicroft et al.   LANCET

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Common variants conferring risk of schizophrenia

(2009) Hreinn Stefansson et al.   NATURE

The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway

(2009) O. D. Howes et al.   SCHIZOPHRENIA BULLETIN

Meta-analysis of 32 genome-wide linkage studies of schizophrenia

(2008) M Y M Ng et al.   MOLECULAR PSYCHIATRY

A framework for interpreting genome-wide association studies of psychiatric disorders

(2008)   MOLECULAR PSYCHIATRY

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

Identification of loci associated with schizophrenia by genome-wide association and follow-up

(2008) Michael C O'Donovan et al.   NATURE GENETICS