Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

The nature of nurture: Effects of parental genotypes

(2018) Augustine Kong et al.   SCIENCE

Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes

(2018) Yu Jiang et al.   PLoS Genetics

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

(2017) E Jorgenson et al.   MOLECULAR PSYCHIATRY

A relationship between the aldosterone–mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans

(2017) E G Aoun et al.   MOLECULAR PSYCHIATRY

Problematic alcohol use and reduced hippocampal volume: a meta-analytic review

(2017) S. Wilson et al.   PSYCHOLOGICAL MEDICINE

RVTESTS: an efficient and comprehensive tool for rare variant association analysis using sequence data: Table 1.

(2016) Xiaowei Zhan et al.   BIOINFORMATICS

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences

(2016) T E Thorgeirsson et al.   MOLECULAR PSYCHIATRY

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Neurobiologic Advances from the Brain Disease Model of Addiction

(2016) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

KLBis associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

(2016) Gunter Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CHRNA5–A3–B4 Gene Cluster and Smoking: From Discovery to Therapeutics

(2016) Glenda Lassi et al.   TRENDS IN NEUROSCIENCES

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

(2016) David Lamparter et al.   PLoS Computational Biology

Forced Expiratory Volume in the First Second and Aldosterone as Mediators of Smoking Effect on Stroke in African Americans: The Jackson Heart Study

(2016) Wei Wang et al.   Journal of the American Heart Association

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Brain on Drugs: From Reward to Addiction

(2015) Nora D. Volkow et al.   CELL

SEQMINER: An R-Package to Facilitate the Functional Interpretation of Sequence-Based Associations

(2015) Xiaowei Zhan et al.   GENETIC EPIDEMIOLOGY

Meta-analysis of the heritability of human traits based on fifty years of twin studies

(2015) Tinca J C Polderman et al.   NATURE GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Cohort Profile: the Health and Retirement Study (HRS)

(2014) A. Sonnega et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A critical time window for dopamine actions on the structural plasticity of dendritic spines

(2014) S. Yagishita et al.   SCIENCE

The effect of alcohol consumption on the adolescent brain: A systematic review of MRI and fMRI studies of alcohol-using youth

(2014) Sarah W. Feldstein Ewing et al.   NeuroImage-Clinical

Unraveling the neurobiology of nicotine dependence using genetically engineered mice

(2013) Astrid K Stoker et al.   CURRENT OPINION IN NEUROBIOLOGY

A Double-Blind, Placebo-Controlled Trial Assessing the Efficacy of Varenicline Tartrate for Alcohol Dependence

(2013) Raye Z. Litten et al.   Journal of Addiction Medicine

Decline in Genetic Influence on the Co-Occurrence of Alcohol, Marijuana, and Nicotine Dependence Symptoms From Age 14 to 29

(2012) Scott I. Vrieze et al.   AMERICAN JOURNAL OF PSYCHIATRY

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

(2012) Bryan Howie et al.   NATURE GENETICS

The National Longitudinal Study of Adolescent Health (Add Health) Sibling Pairs Data

(2012) Kathleen Mullan Harris et al.   Twin Research and Human Genetics

Role of Corticotropin-Releasing Factor in Drug Addiction

(2011) Marian L. Logrip et al.   CNS DRUGS

A New Approach to Account for the Correlations among Single Nucleotide Polymorphisms in Genome-Wide Association Studies

(2011) Zhongxue Chen et al.   HUMAN HEREDITY

ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry

(2011) L J Bierut et al.   MOLECULAR PSYCHIATRY

Full spectrum genetics

(2011)   NATURE GENETICS

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications

(2011) Rita Z. Goldstein et al.   NATURE REVIEWS NEUROSCIENCE

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Psychometric and Genetic Architecture of Substance Use Disorder and Behavioral Disinhibition Measures for Gene Association Studies

(2010) Brian M. Hicks et al.   BEHAVIOR GENETICS

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

Variance component model to account for sample structure in genome-wide association studies

(2010) Hyun Min Kang et al.   NATURE GENETICS

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Genetic and Environmental Influences on Alcohol, Caffeine, Cannabis, and Nicotine Use From Early Adolescence to Middle Adulthood

(2008) Kenneth S. Kendler et al.   ARCHIVES OF GENERAL PSYCHIATRY

Glutamatergic substrates of drug addiction and alcoholism

(2007) Justin T. Gass et al.   BIOCHEMICAL PHARMACOLOGY