Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

The importance of TCF4 gene in the etiology of recurrent depressive disorders

(2018) Joanna Mossakowska-Wójcik et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

News at a glance

(2018)   SCIENCE

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism

(2017) Michelle Luciano et al.   NATURE GENETICS

Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity

(2017) T. Quarto et al.   NEUROSCIENCE

Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants

(2017) Reka Nagy et al.   Genome Medicine

Cognitive ability and physical health: a Mendelian randomization study

(2017) Saskia P. Hagenaars et al.   Scientific Reports

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

Bias due to participant overlap in two-sample Mendelian randomization

(2016) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

(2016) Aysu Okbay et al.   NATURE GENETICS

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent

(2016) Craig L Hyde et al.   NATURE GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1

(2016) Matthew D. Rannals et al.   NEURON

Expansion of the Gene Ontology knowledgebase and resources

(2016)   NUCLEIC ACIDS RESEARCH

Further evidence ofVRK2rs2312147 associated with schizophrenia

(2016) Hong Chang et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

NCAM1-TTC12-ANKK1-DRD2gene cluster and the clinical and genetic heterogeneity of adults with ADHD

(2015) Nina R. Mota et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5

(2015) Kjell Fuxe et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tobacco smoking is causally associated with antipsychotic medication use and schizophrenia, but not with antidepressant medication use or depression

(2015) M. K. Wium-Andersen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Genetic Determinants of Depression

(2015) Erin C. Dunn et al.   HARVARD REVIEW OF PSYCHIATRY

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response

(2015) J M Biernacka et al.   Translational Psychiatry

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS)

(2015) Ana Maria Fernandez-Pujals et al.   PLoS One

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

(2014) Alexander Gusev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory

(2014) Stéphanie M. van den Berg et al.   BEHAVIOR GENETICS

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

Establishing the bidirectional relationship between depression and subclinical arteriosclerosis – rationale, design, and characteristics of the BiDirect Study

(2014) Henning Teismann et al.   BMC Psychiatry

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Amygdala NRG1–ErbB4 Is Critical for the Modulation of Anxiety-Like Behaviors

(2014) Lin-Lin Bi et al.   NEUROPSYCHOPHARMACOLOGY

UK Biobank Data: Come and Get It

(2014) N. E. Allen et al.   Science Translational Medicine

A Genome-Wide Association Study of Depressive Symptoms

(2013) Karin Hek et al.   BIOLOGICAL PSYCHIATRY

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

DGIdb: mining the druggable genome

(2013) Malachi Griffith et al.   NATURE METHODS

Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants

(2013) Daniel J. Smith et al.   PLoS One

Depressive rumination and the C957T polymorphism of the DRD2 gene

(2012) Anson J. Whitmer et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Haploinsufficiency of CELF4 at 18q12.2 is associated with developmental and behavioral disorders, seizures, eye manifestations and obesity

(2012) Christina Halgren et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

RBFOX1 regulates both splicing and transcriptional networks in human neuronal development

(2012) Brent L. Fogel et al.   HUMAN MOLECULAR GENETICS

Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness

(2012) Blair H Smith et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A mega-analysis of genome-wide association studies for major depressive disorder

(2012)   MOLECULAR PSYCHIATRY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

(2012) Ming Li et al.   SCHIZOPHRENIA RESEARCH

CELF4 Regulates Translation and Local Abundance of a Vast Set of mRNAs, Including Genes Associated with Regulation of Synaptic Function

(2012) Jacy L. Wagnon et al.   PLoS Genetics

A high-resolution map of human evolutionary constraint using 29 mammals

(2011) Kerstin Lindblad-Toh et al.   NATURE

Very Early Predictors of Adolescent Depression and Suicide Attempts in Children With Attention-Deficit/Hyperactivity Disorder

(2010) Andrea Chronis-Tuscano et al.   ARCHIVES OF GENERAL PSYCHIATRY

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

Robust relationship inference in genome-wide association studies

(2010) Ani Manichaikul et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Cigarette smoking and depression: a question of causation

(2010) Marcus R. Munafò et al.   BRITISH JOURNAL OF PSYCHIATRY

Cigarette smoking and depression: tests of causal linkages using a longitudinal birth cohort

(2010) Joseph M. Boden et al.   BRITISH JOURNAL OF PSYCHIATRY

Astn2, A Novel Member of the Astrotactin Gene Family, Regulates the Trafficking of ASTN1 during Glial-Guided Neuronal Migration

(2010) P. M. Wilson et al.   JOURNAL OF NEUROSCIENCE

The antidepressant-like effect of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane involves a regulation of β-type estrogen receptors

(2010) Julie Espallergues et al.   PSYCHOPHARMACOLOGY

Exercise-induced histone modifications in human skeletal muscle

(2009) Sean L. McGee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genetic variation in LIN28B is associated with the timing of puberty

(2009) Ken K Ong et al.   NATURE GENETICS

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

(2008) Klaus-Peter Lesch et al.   JOURNAL OF NEURAL TRANSMISSION

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia

(2008) S G Potkin et al.   MOLECULAR PSYCHIATRY