Article
Environmental Sciences
Weixuan Wang, Shuang Li, Xi Wang, Jianbo Wang, Yanshu Zhang
Summary: This study investigated the effect of nano-PbO exposure on lymphocyte cells infiltration and adhesion protein expression in the choroid plexus, as well as the role of reactive oxygen species (ROS) in the process. Results showed that nano-PbO exposure increased lymphocyte cell percentage and upregulated ICAM-1 and VCAM-1 expression. Additionally, nano-PbO treatment led to increased ROS production and decreased antioxidant activity. Inhibition of ROS significantly decreased ICAM-1 and VCAM-1 expression. In conclusion, nano-PbO exposure increases ICAM-1 and VCAM-1 expression through oxidative stress, facilitating lymphocyte infiltration into the brain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Tadashi Uwagawa, Taro Sakamoto, Takeshi Gocho, Hiroaki Shiba, Shinji Onda, Jungo Yasuda, Yoshihiro Shirai, Ryoga Hamura, Kenei Furukawa, Katsuhiko Yanaga, Toru Ikegami
Summary: Combination chemotherapy with nafamostat mesilate, gemcitabine and S-1 may be a promising option for patients with unresectable pancreatic cancer, especially for those with stage IV cancer.
Article
Medical Laboratory Technology
Varinder Singh, Rupinder Kaur, Pratima Kumari, Chirag Pasricha, Ravinder Singh
Summary: Leukocyte migration is vital for lymphocyte recirculation and immune response. ICAM-1 and VCAM-1 play a crucial role in leukocyte adherence to endothelial cells in various diseases. They contribute to inflammation, leukocyte migration, and have implications in multiple pathological states. Understanding their immunoregulatory role and pathophysiological effects helps in disease management.
CLINICA CHIMICA ACTA
(2023)
Article
Biology
Sandra Marinovic Kulisic, Marta Takahashi, Marta Himelreich Peric, Vedrana Muzic Radovic, Ruzica Jurakic Toncic
Summary: This study evaluated the expression of E-selectin, ICAM-1, and VCAM-1 in skin biopsy specimens of patients with AD using a computer program. The results showed that the number of ICAM-1 and VCAM-1 positive cells decreased, while the E-selectin positive epidermal surface area increased in AD patients. The endothelial area positive for E-selectin and ICAM1 was significantly larger in AD-affected skin. In addition, strong signals of E-selectin were detected in skin macrophages and ICAM-1 in dermal vessel endothelium. VCAM-1 signal could not be found in the endothelial cells of AD-affected skin. The expression of E-selectin, ICAM-1, and VCAM-1 shows significant changes in AD-affected skin compared to control skin.
Article
Chemistry, Multidisciplinary
Yan-rou Bei, Shun-chi Zhang, Yu Song, Mao-lin Tang, Ke-lan Zhang, Min Jiang, Run-chao He, Shao-guo Wu, Xue-hui Liu, Li-mei Wu, Xiao-yan Dai, Yan-wei Hu
Summary: Atherosclerosis is a chronic inflammatory disease in which monocyte adhesion to endothelial cells plays a crucial role. This study shows that the novel gene EPSTI1 is significantly upregulated in atherosclerotic plaques and promotes monocyte adhesion to endothelial cells by increasing the expression of VCAM-1 and ICAM-1. The expression of EPSTI1 is regulated by LPS and is dependent on p65 nuclear translocation. These findings suggest that EPSTI1 may play a potential role in the development of atherosclerosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Ching-Kai Shen, Bor-Ren Huang, Wei-Lan Yeh, Chao-Wei Chen, Yu-Shu Liu, Sheng-Wei Lai, Wen-Pei Tseng, Dah-Yuu Lu, Cheng-Fang Tsai
Summary: This study showed that IL-1 beta induces the expression of ICAM-1 and VCAM-1 in GBM cells, leading to increased adhesive interaction between monocytes and GBM cells. Additionally, IL-1 beta also triggers the production of soluble ICAM-1 and VCAM-1 in GBM, which plays a crucial role in regulating tumor-associated monocyte/macrophage polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Keishi Yamasaki, Koji Nishi, Kenji Tsukigawa, Kazuaki Taguchi, Masaki Otagiri, Hakaru Seo
Summary: This study examined several factors that may lead to the formation of precipitates when using Nafamostat mesilate (NFM) as an anticoagulant during hemodialysis. It was found that precipitates could form under certain conditions, potentially disrupting the dialysis process.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biotechnology & Applied Microbiology
Qian Zhang, Wei Zhang, Jing Liu, Haisen Yang, Yuxia Hu, Mengdi Zhang, Tuya Bai, Fuhou Chang
Summary: The study investigated the regulatory role of LPC on endothelial cell adhesion marker expression, suggesting that the LPC-G2A-ICAM-1/VCAM-1 pathway may contribute to atherogenic activity of oxLDL, with NF-kappa B antagonists potentially serving as effective therapeutic tools for cardiovascular diseases.
Article
Gastroenterology & Hepatology
Boram Lee, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Moonhwan Kim, Yeongsoo Jo
Summary: In this retrospective study, nafamostat mesilate (NM) was found to reduce the risk of posthepatectomy liver failure (PHLF) in patients with hepatocellular carcinoma. The administration of NM led to a lower incidence of PHLF, decreased postoperative levels of liver biomarkers, and reduced rates of major complications and hospital stays.
Article
Oncology
Kyungho Kim, Eun-Young Choi, Hye-Mi Ahn, Dong-Gun Kim, Youn-Jae Kim
Summary: This study investigates the role of HBQ1 in lung adenocarcinoma and finds that elevated expression of HBQ1 in adenocarcinoma tissues is associated with poor survival. HBQ1 acts as an oncogene, promoting cell proliferation, and also has antioxidant properties. The findings suggest that HBQ1 plays a crucial role in lung adenocarcinoma progression and may serve as a diagnostic marker and therapeutic target.
Article
Medicine, General & Internal
Sophie Meixensberger, Hanna Kuzior, Bernd L. Fiebich, Patrick Suess, Kimon Runge, Benjamin Berger, Kathrin Nickel, Dominik Denzel, Miriam A. Schiele, Maike Michel, Simon Maier, Karl Bechter, Katharina Domschke, Ludger Tebartz van Elst, Dominique Endres
Summary: The levels of sICAM-1 and sVCAM-1 in the CSF were higher in patients with schizophrenia spectrum disorder compared to those with depression, indicating endothelial dysfunction underlying BBB/BCSFB impairment. Additionally, a significant correlation of sVCAM-1 with CSF protein and AQ levels was observed in patients with schizophrenia spectrum disorders.
Article
Cell Biology
Peng Chen, Li-Jun Zhao, Ling Huang, Wen-Qi He, Ying-Rui Tang, Yi Liu, Jian-Dong Ren
Summary: Our study investigated the protective effect of Nafamostat mesilate (NM) on pancreatic injury and its inhibitory effect on NOD-like receptor protein 3 (NLRP3) inflammasome activation in an experimental mouse model of acute pancreatitis (AP). We found that NM significantly suppressed NLRP3 inflammasome activation in the pancreas, reducing pancreatic inflammation and preventing pancreatic injury during AP. NM was also found to interact with histone deacetylase 6 (HDAC6) and inhibit its function, which influenced NF-κB transcriptional activity and prevented NLRP3 inflammasome priming. Furthermore, NM disrupted the association between HDAC6 and NLRP3, impeding the intracellular transport of NLRP3 and ultimately preventing NLRP3 inflammasome activation.
INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Joo Seong Kim, Sang Hyub Lee, Namyoung Park, Gunn Huh, Jung Won Chun, Jin Ho Choi, In Rae Cho, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim
Summary: The administration of nafamostat mesilate after ERCP in high-risk patients was not effective in preventing PEP, but may attenuate the severity of PEP.
BMC GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Umar Mushtaq, Muneesa Bashir, Sumaiya Nabi, Firdous A. Khanday
Summary: This review discusses the synergistic role of EGFR and integrins in regulating ROS production through various signaling pathways. The functional interactions between these receptors result in activation of downstream targets such as MAPK and gene expression through redox signaling. This mutual regulation of crosstalk between EGFR and integrins may have implications for therapeutic interventions and targeted antioxidant therapies.
Article
Agriculture, Dairy & Animal Science
Tong Zhang, Jiaxin Zhang, Ruilan Li
Summary: This study investigated the expression pattern and functional characteristics of p66Shc during preimplantation embryo development in sheep. The results showed that p66Shc was expressed in all stages of sheep early embryos and its expression was regulated during embryonic genome activation. RNAi-mediated knockdown of p66Shc resulted in decreased levels of ROS and DNA damage, and increased levels of antioxidant enzymes. This suggests that p66Shc is involved in the regulation of oxidative stress and DNA damage during sheep early embryonic development.
Editorial Material
Biochemistry & Molecular Biology
Byeong Hwa Jeon
Article
Biochemistry & Molecular Biology
Yu-Ran Lee, Eun Young Bae, Hong Ryang Kil, Byeong-Hwa Jeon, Geena Kim
Summary: This study investigated the association between APE1/Ref-1 and Kawasaki disease (KD). The results showed that APE1/Ref-1 levels were significantly higher in KD patients, especially in refractory KD. APE1/Ref-1 could be a beneficial biomarker for the diagnosis and prognosis of KD.
Article
Biochemistry & Molecular Biology
Su-jeong Choi, Harsha Nagar, Jun Wan Lee, Seonhee Kim, Ikjun Lee, Shuyu Piao, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: This study found that IDH2 deficiency induced increased expression of SDC2 in endothelial cells, with MMP7 and TGF-beta signaling playing regulatory roles. UTI could reverse the increase in SDC2, MMP7, and TGF-beta signaling caused by IDH2 deficiency.
Article
Biochemistry & Molecular Biology
Sunga Choi, Yu-Ran Lee, Ki-Mo Kim, Euna Choi, Byeong-Hwa Jeon
Summary: The regulation of inflammatory signaling in the tumor microenvironment using adenoviral-mediated PPTLS-APE1/Ref-1 can inhibit the activity of inflammatory immune cells and cancer cells, providing a potential therapeutic strategy for treating triple-negative breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sungmin Kim, Yu-Ran Lee, Eun-Ok Lee, Hao Jin, Yeon-Hee Choi, Hee-Kyoung Joo, Byeong-Hwa Jeon
Summary: This study found that dietary capsanthin has anti-inflammatory and anti-vascular inflammation effects on atherosclerotic mice, reducing plaque formation and inflammatory marker levels.
Article
Integrative & Complementary Medicine
Seonhee Kim, Harsha Nagar, Ikjun Lee, Su-Jeong Choi, Shuyu Piao, Byeong Hwa Jeon, Shin Kwang Kang, Hee-Jung Song, Cuk-Seong Kim
Summary: Breast cancer is a common and deadly disease, especially in triple-negative breast cancer (TNBC) cases. This study investigates the potential of sericite, a natural mineral, as an antitumor agent for TNBC. The results show that sericite can inhibit cell proliferation, induce cell cycle arrest, and promote apoptotic cell death. These findings suggest that sericite could be a potential therapeutic option for TNBC.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biology
Seonhee Kim, Ikjun Lee, Shuyu Piao, Harsha Nagar, Su-Jeong Choi, Young-Rae Kim, Kaikobad Irani, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: It has been found that miR204 plays a role in promoting the development of non-alcoholic fatty liver disease by regulating hepatic fatty acid metabolism and inflammation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyeok Hee Kwon, Seung Yeon Jung, Hyewon Park, Hyo Jung Shin, Dong Woon Kim, Hee-Jung Song, Joon Won Kang
Summary: Oxygenated water has antiepileptic effects on rodent models, increasing the seizure threshold and reducing the frequency and duration of seizures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eun-Ok Lee, Hee-Kyoung Joo, Yu-Ran Lee, Sungmin Kim, Kwon-Ho Lee, Sang-Do Lee, Byeong-Hwa Jeon
Summary: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is involved in DNA repair and redox regulation. It inhibits adipocyte differentiation by regulating adipogenic transcription factors, suggesting it as a potential therapeutic target for regulating adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shuyu Piao, Ikjun Lee, Seonhee Kim, Hyewon Park, Harsha Nagar, Su-Jeong Choi, Giang-Huong Vu, Minsoo Kim, Eun-Ok Lee, Byeong-Hwa Jeon, Dong Woon Kim, Youngduk Seo, Cuk-Seong Kim
Summary: This study investigates the role of CRIF1 deficiency in modulating mitochondrial oxidative phosphorylation (OXPHOS) system dysfunction and its antitumor effects in MCF-7 breast cancer cells. CRIF1 silencing decreases the assembly of mitochondrial OXPHOS complexes, leading to mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels. Inhibition of CRIF1 suppresses cell proliferation and inhibits cell migration in MCF-7 cells, and intratumoral injection of CRIF1 siRNA nanoparticles inhibits tumor growth in MCF-7 xenograft mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Minsoo Kim, Giang-Huong Vu, Byeong-Hwa Jeon, Cuk-Seong Kim
Summary: Endothelial senescence impairs vascular function and is a major factor in age-related vasculature diseases. IDH2 is involved in the production of alpha-ketoglutarate and preservation of mitochondrial function. However, the mechanism and regulation of IDH2 in endothelial senescence have not been fully understood.