Article
Chemistry, Applied
Jae-chun Lee, Kurniawan Kurniawan, Sookyung Kim, Viet Tu Nguyen, Banshi D. Pandey
Summary: This paper reviews the extraction and separation of precious metal-chloro complexes using ionic liquids, discussing the mechanisms, advantages, and drawbacks of IL-assisted solvent extraction. It also presents the effects of operational conditions, stripping, regeneration of loaded ILs, and potential use of ionic liquids in other separation methods. The development and application of IL-assisted solvent extraction in the separation of precious metals are highlighted, along with a proposed flow-sheet for the process.
SEPARATION AND PURIFICATION REVIEWS
(2023)
Article
Acoustics
Sooridarsan Krishnan, Noraini Abd Ghani, Noor Fathanah Aminuddin, Khurrum Shehzad Quraishi, Beatrice Luciana Razafindramangarafara, Stephane Baup, Jean-Marc Leveque
Summary: This study investigates the potential of using small amounts of ionic liquids to enhance ultrasound-assisted extraction of lipids content from green microalgae. The findings suggest that the addition of ILs improves ultrasonication by enhancing viscosity and reducing water surface tension, resulting in a more powerful acoustic cavitation process. Additionally, the yield of extracted lipids from green microalgae shows an incremental trend with increasing IL concentration.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Acoustics
Wenxue Zhang, Liurong Huang, Wenwen Chen, Jiale Wang, Shiheng Wang
Summary: The combination of dual-frequency ultrasound and ionic liquids can significantly improve the functional properties of SPI hydrolysates, increasing degree of hydrolysis and protein hydrolysate properties, but the effects on foaming and antioxidant activities vary depending on the type of treatment.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xiu-zheng Gao, Xu-tao Lv, Rui-rui Zhang, Yang Luo, Mu-xuan Wang, Jia-shu Chen, Yu-kai Zhang, Bin Sun, Jin-yue Sun, Yu-fa Liu, Chao Liu
Summary: This study synthesized twenty new Tet and d-Tet derivatives, with ten showing better cytotoxic effects than the parent compounds, and compound 4g exhibited the strongest cell growth inhibitory activity. Further investigation revealed that compound 4g inhibited A549 cell proliferation by arresting the G2/M cell cycle, reducing MMP-2 and MMP-9 expression, inducing apoptosis through the intrinsic pathway regulated by mitochondria, and blocking the PI3K/Akt/mTOR pathway. These findings suggest that compound 4g may be a promising drug candidate for lung cancer therapy.
BIOORGANIC CHEMISTRY
(2021)
Article
Energy & Fuels
Shiva Rezaei Motlagh, Amal A. Elgharbawy, Ramin Khezri, Razif Harun, Rozita Omar
Summary: The study demonstrated that microwave-assisted extraction using ionic liquids, particularly choline acetate, was effective in extracting proteins from microalgae biomass. This method outperformed the conventional Soxhlet method, with higher protein yield and less environmental hazards. The innovative procedure shows promise for significant protein separation and utilization in bioproduct technologies.
BIOMASS CONVERSION AND BIOREFINERY
(2021)
Article
Chemistry, Physical
Qiruonan Shen, Ting Zhu, Caie Wu, Yujuan Xu, Chunmei Li
Summary: This study established an efficient simultaneous extraction and saponification method for zeaxanthin from L. barbarum using a composite solvent and ultrasound-assisted extraction, improving the extraction yield and shortening the extraction time. The extraction mechanism was investigated using quantum chemical calculations, revealing the main driving forces.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Integrative & Complementary Medicine
Eric Wei Chiang Chan, Siu Kuin Wong, Hung Tuck Chan
Summary: Tetrandrine (TET) and fangchinoline (FAN) are dominant bisbenzylisoquinoline alkaloids from the roots of Stephania tetrandra, showing anticancer properties on colon and breast cancer cells. They inhibit cell proliferation and migration through various molecular mechanisms and signaling pathways, with potential to reverse multidrug resistance in cancer cells.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Chemistry, Multidisciplinary
Edgar Suarez Garcia, Carlota F. Miranda, M. Teresa Cesario, Rene H. Wijffels, Corjan van den Berg, Michel H. M. Eppink
Summary: A novel extraction and fractionation concept using Ionic Liquids (ILs) was proposed to extract and recover proteins and carbohydrates from macroalgae. The process involved IL-assisted mechanical shear for initial extraction and two-phase partitioning or ultrafiltration for fractionation. The selective extraction of proteins and the preservation of their native structure were demonstrated. The potential application of this approach in the biorefinery of macroalgae was highlighted.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Analytical
Slavica Razic, Jelena Arsenijevic, Svetlana Dogo Mracevic, Jasmina Musovic, Tatjana Trtic-Petrovic
Summary: To meet the high standards of sustainable chemistry and human welfare, more environment-friendly solvents are essential in analytical chemistry for sample preparation and analysis. This review paper critically examines the advantages and unresolved problems of various green solvents, providing an overview of the current state-of-the-art in this field. Replacing volatile organic compounds with eco-friendly solvents in extractions/separations is crucial for sustainable chemistry.
Article
Chemistry, Analytical
Sainan Li, Yanjie Li, Ying Wang, Ruizhe Li, Huazhou Niu, Chunming Liu, Yuchi Zhang
Summary: A method for rapid screening and identification of ligands for monoamine oxidase B was developed, alongside a new ultrasound-assisted extraction method for medicinal herbs. A hyphenated technique combining countercurrent chromatography and semipreparative-LC was used to isolate chemical constituents for Pueraria thomsonii Benth. Results showed potent monoamine oxidase B inhibitors and evaluated their anti-Alzheimer activity using a PC12 cell model. The protocol demonstrated high accuracy and efficiency.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Food Science & Technology
Jiahao Yu, Xuwei Liu, Lianfu Zhang, Ping Shao, Weina Wu, Zhirong Chen, Jiandong Li, Catherine M. G. C. Renard
Summary: This study discusses the use of green solvents for carotenoid extraction, as well as the development of efficient extraction processes through the combination of these solvents with novel extraction techniques.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenxue Zhang, Issac Duah Boateng, Wenjing Zhang, Shifang Jia, Tingting Wang, Liurong Huang
Summary: This study found that the application of dual-frequency ultrasound-assisted ionic liquids (UA-IL) pretreatment can change the structure and interfacial properties of soy protein isolate (SPI). The pretreatment can loosen the protein structure and expose hydrophobic groups initially hidden inside molecules. After the ionic liquids pretreatment, the solubility, emulsion activity, foaming capacity, and foaming stability of the protein were significantly improved.
PROCESS BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Samaneh Barani Pour, Jaber Jahanbin Sardroodi, Alireza Rastkar Ebrahimzadeh, Gholamreza Pazuki
Summary: In this study, we investigated the interaction between hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD) in binary mixtures. The findings revealed that the presence of Cl- anion is crucial for the formation of deep eutectic solvents (DESs). Moreover, the structural stability of DESs based on fatty acids (FAs) and choline chloride (Ch(+)Cl(-)) at different ratios was examined using molecular dynamics simulations in water. It was observed that the interaction between the chloride anion and the cation's hydroxyl group causes HBA to transition to the water-rich phase. These atomic sites play a significant role in the stability of eutectic mixtures containing FAs and Cl- anion. Notably, the binary mixture with a mole percent of 30% [Ch(+)Cl(-)] and 70% FAs exhibited higher stability compared to other ratios.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Analytical
Rosa A. Perez, Beatriz Albero
Summary: Ultrasound-assisted extraction is widely used for extracting organic contaminants from solid samples, and it can be easily applied to various matrices using a wide range of solvents. Recent developments have combined sonication with microextraction techniques for liquid samples, with a focus on reducing traditional organic solvents and exploring alternatives like ionic liquids and deep eutectic solvents. This review discusses the new applications of ultrasound-assisted extraction in the determination of organic contaminants, with an emphasis on implementing the principles of Green Analytical Chemistry to minimize environmental impact. The article reviews ultrasound-assisted extraction methods proposed in the last five years (2018-2022) to provide an updated overview.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Esteban Quijada-Maldonado, Julio Romero
Summary: This review analyzes the performance of ionic liquids (ILs) as separating media for selective and sustainable extraction of rare-earth elements (REEs), showing high selectivities in separating heavy from light REEs, but facing challenges in adjacent REE separation. Insights are provided for selective and sustainable extraction of REEs using ILs.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2021)
