Article
Infectious Diseases
Mahoko Ikeda, Shu Okugawa, Kosuke Kashiwabara, Takashi Moritoyo, Yoshiaki Kanno, Daisuke Jubishi, Hideki Hashimoto, Koh Okamoto, Kenji Tsushima, Yasuki Uchida, Takahiro Mitsumura, Hidetoshi Igari, Takeya Tsutsumi, Hideki Araoka, Kazuhiro Yatera, Yoshihiro Yamamoto, Yuki Nakamura, Amato Otani, Marie Yamashita, Yuji Wakimoto, Takayuki Shinohara, Maho Adachi-Katayama, Tatsunori Oyabu, Aoi Kanematsu, Sohei Harada, Yuichiro Takeshita, Yasutaka Nakano, Yasunari Miyazaki, Seiichiro Sakao, Makoto Saito, Sho Ogura, Kei Yamasaki, Hitoshi Kawasuji, Osamu Hataji, Jun-Ichiro Inoue, Yasuyuki Seto, Kyoji Moriya
Summary: This study evaluated the efficacy and safety of nafamostat combined with favipiravir for the treatment of COVID-19. The results showed that patients in the combination group had a shorter time to improvement in body temperature and a greater improvement in oxygen saturation, but no significant difference in clinical progression. The incidence of phlebitis was higher in the combination group.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Philipp Reus, Hadar Guthmann, Nadja Uhlig, Majd Agbaria, Leila Issmail, Valentina Eberlein, Mirjam M. Nordling-David, Doaa Jbara-Agbaria, Sandra Ciesek, Denisa Bojkova, Jindrich Cinatl, Anke Burger-Kentischer, Steffen Rupp, Andrea Zaliani, Thomas Grunwald, Philip Gribbon, Aimo Kannt, Gershon Golomb
Summary: This study explores the repurposing of drugs for the treatment of COVID-19 using liposomal formulations. Targeted liposomes administered intranasally showed enhanced accumulation in the lungs, suggesting potential therapeutic efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
Pablo Jose Antunez Muinos, Diego Lopez Otero, Ignacio J. Amat-Santos, Javier Lopez Pais, Alvaro Aparisi, Carla E. Cacho Antonio, Pablo Catala, Teba Gonzalez Ferrero, Gonzalo Cabezon, Oscar Otero Garcia, Jose Francisco Gil, Marta Perez Poza, Jordi Candela, Gino Rojas, Victor Jimenez Ramos, Carlos Veras, J. Alberto San Roman, Jose R. Gonzalez-Juanatey
Summary: The study aimed to establish laboratory predictors of mortality in COVID-19 disease in order to identify high-risk patients. By analyzing various laboratory biomarkers, a Covid-19 Lab score was created to predict mortality, with different risk groups identified based on the score. The score was found to be a simple and dynamic tool that could effectively predict mortality in patients with SARS-CoV2 infection.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Zhongwei Jia, Xiangyu Yan, Liwei Gao, Shenggang Ding, Yan Bai, Yuejie Zheng, Yuxia Cui, Xianfeng Wang, Jingfeng Li, Gen Lu, Yi Xu, Xiangyu Zhang, Junhua Li, Ning Chen, Yunxiao Shang, Mingfeng Han, Jun Liu, Hourong Zhou, Cen Li, Wanqiu Lu, Jun Liu, Lina Wang, Qihong Fan, Jiang Wu, Hanling Shen, Rong Jiao, Chunxi Chen, Xiaoling Gao, Maoqiang Tian, Wei Lu, Yonghong Yang, Gary Wing-Kin Wong, Tianyou Wang, Runming Jin, Adong Shen, Baoping Xu, Kunling Shen
Summary: Majority clinical characteristics of pediatric COVID-19 pneumonia patients were milder than non-COVID-19 patients. However, lymphocytopenia remained a prominent feature of COVID-19 pediatric pneumonia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Sergey Zhuravel, Oleg K. Khmelnitskiy, Oleg O. Burlaka, Alexey Gritsan, Boris M. Goloshchekin, Seieun Kim, Ka Young Hong
Summary: The study found no significant difference in the time to clinical improvement between the nafamostat and standard-of-care groups for COVID-19 pneumonia patients overall, but nafamostat showed a significantly shorter time to clinical improvement in a small subgroup of high-risk patients requiring oxygen treatment.
Article
Cell Biology
Bo Yu, Chenze Li, Yang Sun, Dao Wen Wang
Summary: Insulin treatment for patients with COVID-19 and T2D was found to be associated with a significant increase in mortality according to a retrospective study. Further analysis showed that insulin treatment was linked to enhanced systemic inflammation and aggravated injuries of vital organs, suggesting that caution should be exercised when using insulin treatment for these patients.
Article
Computer Science, Artificial Intelligence
Xiang Bai, Hanchen Wang, Liya Ma, Yongchao Xu, Jiefeng Gan, Ziwei Fan, Fan Yang, Ke Ma, Jiehua Yang, Song Bai, Chang Shu, Xinyu Zou, Renhao Huang, Changzheng Zhang, Xiaowu Liu, Dandan Tu, Chuou Xu, Wenqing Zhang, Xi Wang, Anguo Chen, Yu Zeng, Dehua Yang, Ming-Wei Wang, Nagaraj Holalkere, Neil J. Halin, Ihab R. Kamel, Jia Wu, Xuehua Peng, Xiang Wang, Jianbo Shao, Pattanasak Mongkolwat, Jianjun Zhang, Weiyang Liu, Michael Roberts, Zhongzhao Teng, Lucian Beer, Lorena E. Sanchez, Evis Sala, Daniel L. Rubin, Adrian Weller, Joan Lasenby, Chuangsheng Zheng, Jianming Wang, Zhen Li, Carola Schonlieb, Tian Xia
Summary: Artificial intelligence shows promise in streamlining COVID-19 diagnoses, but concerns around security and trustworthiness hinder the collection of large-scale medical data. The Unified CT-COVID AI Diagnostic Initiative (UCADI) introduces a federated learning framework for training AI models without data sharing, achieving comparable performance with professional radiologists. This study, based on data from 23 hospitals in China and the UK, advances the use of federated learning for privacy-preserving AI in digital health.
NATURE MACHINE INTELLIGENCE
(2021)
Article
Medicine, General & Internal
Chienhsiu Huang
Summary: The lockdown strategies during the COVID-19 pandemic significantly reduced common respiratory viral diseases and hospitalization among children, but the impact on non-COVID-19 pneumonia in adults was uncertain. The study found a substantial decrease in both community-acquired and hospital-acquired pneumonia cases among adults in 2020 compared to 2019, especially in older age groups and late seasons.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Peter Horby, Wei Shen Lim, Jonathan R. Emberson, Marion Mafham, Jennifer L. Bell, Louise Linsell, Natalie Staplin, Christopher Brightling, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Christopher Green, Timothy Felton, David Chadwick, Kanchan Rege, Christopher Fegan, Lucy C. Chappell, Saul N. Faust, Thomas Jaki, Katie Jeffery, Alan Montgomery, Kathryn Rowan, Edmund Juszczak, J. Kenneth Baillie, Richard Haynes, Martin J. Landray
Summary: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Andrea Delli Pizzi, Antonio Maria Chiarelli, Piero Chiacchiaretta, Cristina Valdesi, Pierpaolo Croce, Domenico Mastrodicasa, Michela Villani, Stefano Trebeschi, Francesco Lorenzo Serafini, Consuelo Rosa, Giulio Cocco, Riccardo Luberti, Sabrina Conte, Lucia Mazzamurro, Manuela Mereu, Rosa Lucia Patea, Valentina Panara, Stefano Marinari, Jacopo Vecchiet, Massimo Caulo
Summary: Ground-glass opacities (GGOs) are a common finding in early COVID-19 pneumonia, but can also be seen in other acute lung diseases. A radiomics-based machine learning method showed potential to accurately differentiate GGOs caused by COVID-19 from those caused by other lung diseases, mainly based on texture-related features.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Itai Bendavid, Liran Statlender, Leonid Shvartser, Shmuel Teppler, Roy Azullay, Rotem Sapir, Pierre Singer
Summary: In this study, a two-step model was developed to predict the need for invasive mechanical ventilation (IMV) in hypoxemic patients. The model was trained on non-COVID-19 patient data and then adapted to a COVID-19 patient dataset. The results showed that the adaptation of the model significantly improved the prediction accuracy.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Dan Ma, Ximin Wang, Min Li, Chujiao Hu, Lei Tang
Summary: Periodic pandemics of coronavirus-related pneumonia have been a significant challenge since the outbreak of SARS and MERS. The ongoing COVID-19 pandemic poses a substantial threat to public health. Limited antiviral agents have been approved, and IFNs have shown promising outcomes in the treatment of SARS-CoV or MERS-CoV, but their efficacy and safety in COVID-19 treatment remain unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Tat Ming Ng, Sean W. X. Ong, Audrey Y. X. Loo, Sock Hoon Tan, Hui Lin Tay, Min Yi Yap, David C. Lye, Tau Hong Lee, Barnaby E. Young
Summary: Antibiotic therapy did not improve clinical outcomes for COVID-19 pneumonia patients and more research is needed to diagnose bacterial co-infections in these patients, as indicated by an observational cohort study in Singapore hospitals from January to April 2020.
Article
Medicine, General & Internal
Aurelien Dinh, Jean-Christophe Mercier, Luc Jaulmes, Jean-Yves Artigou, Yves Juilliere, Youri Yordanov, Patrick Jourdain
Summary: This study evaluated the safety of early discharge home with remote monitoring for patients with severe COVID-19 who still required low-oxygen therapy, showing positive outcomes with no deaths or urgent hospitalizations.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Jesus Fuentes-Antras, Aranzazu Manzano, Gloria Marquina, Mateo Paz, Carlos Aguado, Monica Granja, Javier Benitez, Justo Ortega, Araceli Priego, Carlos Gonzalez, Julia Tejerina-Peces, Paloma Flores, Alfonso Lopez de Sa, Carmen Toledano, Jennifer Olalla, Alicia de Luna, Jorge Bartolome, Pedro Perez-Segura
Summary: The COVID-19 pandemic has a significant impact on cancer patients, especially when symptoms such as dyspnea and low oxygen saturation levels present. Study findings show that patients with features on admission such as dyspnea, higher qSOFA score, higher C-reactive protein levels, and abnormal neutrophil count are at higher risk of in-hospital death.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Wan Beom Park, Kang Il Jun, Gayeon Kim, Jae-Phil Choi, Ji-Young Rhee, Shinhyea Cheon, Chang Hyun Lee, Jun-Sun Park, Yeonjae Kim, Joon-Sung Joh, Bum Sik Chin, Pyeong Gyun Choe, Ji Hwan Bang, Sang-Won Park, Nam Joong Kim, Dong-Gyun Lim, Yeon-Sook Kim, Myoung-Don Oh, Hyoung-Shik Shin
JOURNAL OF KOREAN MEDICAL SCIENCE
(2018)
Article
Infectious Diseases
Sukbin Jang, Ji-Young Rhee, Yu Mi Wi, Bo Kyeung Jung
Summary: This study focused on viral kinetics of COVID-19 in patients, revealing a high viral load on the day of symptom development with subsequent decrease. Rapid viral proliferation was observed 0-5 days before symptoms, and the lowest viral load was found 5-10 days after symptom onset, with rRT-PCR results turning negative approximately 3 weeks later.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Hye Jin Shi, Eliel Nham, Bomi Kim, Eun-Jeong Joo, Hae Suk Cheong, Shin Hee Hong, Miri Hyun, Hyun ah Kim, Sukbin Jang, Ji-Young Rhee, Jungok Kim, Sungmin Kim, Hyun Kyu Cho, Yu Mi Wi, Shinhye Cheon, Yeon-Sook Kim, Seungjin Lim, Hyeri Seok, Sook In Jung, Joong Sik Eom, Kyong Ran Peck
Summary: This study compared the clinical features and mortality risk factors of critical COVID-19 cases in Korea among patients aged 50 and below and those above 50. The study found that age, mechanical ventilation therapy, creatinine levels, and blood stream infection were independent predictors of mortality. Additionally, the study highlighted the high obesity rate and low vaccination rate among younger patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Infectious Diseases
Ji-Young Rhee, Jae-Hoon Song, Kwan Soo Ko
INFECTION AND CHEMOTHERAPY
(2016)
Article
Infectious Diseases
Ji Young Rhee, Dong Sik Jung, Kyong Ran Peck
Infection and Chemotherapy
(2016)
