Article
Food Science & Technology
Jaff Ribeiro da Silva, Mariana Barros de Cerqueira e Silva, Biane Oliveira Philadelpho, Victoria Cruz de Souza, Johnnie Elton Machado dos Santos, Marcelo Santos Castilho, Ederlan de Souza Ferreira, Eduardo Maffud Cilli
Summary: The newly designed peptides Pyr-GF and GSTLN enhance the inhibitory effect of pravastatin on HMGCoAR, with the combination showing more significant inhibition compared to pravastatin alone. The peptides demonstrate a cholesterol-lowering effect and act as adjuvants when combined with pravastatin, with Pyr-GF mainly targeting the catalytic site and GSTLN targeting the NADPH site of HMGCoAR.
Article
Cardiac & Cardiovascular Systems
Jonas Ghouse, Gustav Ahlberg, Anne Guldhammer Skov, Henning Bundgaard, Morten S. Olesen
Summary: Inhibition of the HMGCR gene was found to be associated with an increased risk of cataract, suggesting that long-term statin treatment may lead to cataract formation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Maria Giovanna Lupo, Silvia Marchiano, Maria Pia Adorni, Francesca Zimetti, Massimiliano Ruscica, Maria Francesca Greco, Alberto Corsini, Nicola Ferri
Summary: Overexpression of PCSK9 in rat SMCs led to downregulation of LDL receptor and marker of contractile phenotype. This resulted in increased cell proliferation rate and partial resistance to simvastatin, indicating a potential role of PCSK9 in atherosclerotic plaque development and pharmacological response to statins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Kush K. K. Patel, Khosrow Kashfi
Summary: Cholesterol is a vital molecule for maintaining normal physiological homeostasis and serves as a precursor for various substances. However, high cholesterol levels are associated with diseases and cancer progression. Mechanisms for cholesterol-mediated cancer progression include activation of oncogenic signaling pathways and induction of oxidative stress. Lipoprotein molecules HDL and LDL play important roles in this pathogenesis. Some cholesterol-lowering medications may have potential in cancer treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Serkan Yigitkan, Abdulselam Ertas, Ramin Ekhteiari Salmas, Mehmet Firat, Ilkay Erdogan Orhan
Summary: This study investigated the HMG-CoA reductase inhibitory potential of extracts from the roots and aerial parts of Salvia multicaulis Vahl. and identified 7-acetoxyhorminone as the most effective inhibitory compound.
Article
Pharmacology & Pharmacy
Idit Lavi, Naomi Gronich
Summary: This study found that antibiotic treatment is associated with increased cholesterol levels in highly adherent statin users, particularly in relation to macrolides and clindamycin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biology
Muhammad Bilal Azmi, Saleha Sultana, Sadaf Naeem, Shamim Akhtar Qureshi
Summary: The study investigated the in silico activity of alkaloids from Rauwolfia serpentina roots as inhibitors of HMGCR. Five alkaloids were identified as potential inhibitors of HMGCR, showing promising results for suppressing cholesterol biosynthesis pathway.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pediatrics
Keisuke Watanuki, Hiroshi Koga
Summary: This article reports a pediatric case of anti-HMGCR myopathy accompanied by skin rash, and summarizes the clinical characteristics of 33 pediatric patients with anti-HMGCR myopathy. The results indicate that erythematous rash may provide a clue to the diagnosis of anti-HMGCR myopathy in children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Shihao Ding, Bingting Yu, Anneke J. van Vuuren
Summary: Research has shown that inhibiting cholesterol synthesis can effectively suppress the replication of rotavirus, while increasing cholesterol production can enhance rotavirus replication. Therefore, cholesterol homeostasis plays a crucial role in the replication of rotavirus.
Review
Environmental Sciences
Sukhbir Singh, Ishrat Zahoor, Neelam Sharma, Tapan Behl, Neha Kanojia, Aayush Sehgal, Syam Mohan, Yosif Almoshari, Ahmad Salawi, Lotfi Aleya, Simona Bungau
Summary: Hyperlipidemia, characterized by high levels of lipids and lipoproteins in blood circulation, is the primary cause of heart disorders. Pharmacologic therapy and lifestyle adjustments can be used for both primary and secondary prophylaxis of heart disease. Statins, particularly HMG-CoA reductase inhibitors, are preferred for primary prevention. Recent advancements in nanoparticle drug carriers for statins in hyperlipidemia therapy are discussed in this review.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Dulce Andrade-Pavon, Vanessa Fernandez-Munoz, Wendy Gonzalez-Ibarra, Cesar Hernandez-Rodriguez, J. Antonio Ibarra, Lourdes Villa-Tanaca
Summary: The study aimed to explore the function of key amino acid residues in enzymatic activity by obtaining, purifying, characterizing, and overexpressing five point mutations in highly conserved regions of the catalytic domain of Candida glabrata HMGR. The results showed that E711Q mutation exhibited the lowest enzymatic activity and binding energy, suggesting the importance of Glu(711) in the substrate binding site.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Ciaran N. Kohli-Lynch, James Lewsey, Kathleen A. Boyd, Dustin D. French, Neil Jordan, Andrew E. Moran, Naveed Sattar, David Preiss, Andrew H. Briggs
Summary: This study evaluates the cost-effectiveness of expanding preventive statin eligibility and novel approaches to prioritization from a Scottish health sector perspective. The findings suggest that generic pricing has made preventive statin therapy cost-effective for many adults. Additionally, an approach using absolute risk reduction (ARR)-guided therapy is more effective and cost-effective than the traditional method based on 10-year risk assessment.
Article
Neurosciences
Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, Jiao Wang, Xusheng Huang
Summary: This Mendelian randomization (MR) study aimed to assess the association between genetically proxied cholesterol and the age at onset of Huntington's disease (HD). The results showed that plasma cholesterol levels and HMG-CoA reductase inhibition were not associated with the age at onset of HD.
Article
Dentistry, Oral Surgery & Medicine
Iskra A. Signore, Karina Palma, Gabriela Soto, Santiago Sepulveda, Jose Suazo, Millisent Aranguiz, Alicia Colombo
Summary: Impaired function of HMGCR in zebrafish leads to craniofacial malformations and orofacial cleft, mainly affecting the post-migratory neural crest cells. HMGCR plays a crucial role in the morphology of chondrocytes and proliferation/apoptosis in the developing palate and jaw.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2023)
Article
Clinical Neurology
Bojana Petek, Henrike Habel, Hong Xu, Marta Villa-Lopez, Irena Kalar, Minh Tuan Hoang, Silvia Maioli, Joana B. Pereira, Shayan Mostafaei, Bengt Winblad, Milica Gregoric Kramberger, Maria Eriksdotter, Sara Garcia-Ptacek
Summary: This study explores the association between the use of lipid-lowering medications and cognitive decline over time in patients with AD or mixed dementia. The results suggest that statin treatment may benefit cognitive function in some patients with AD or mixed dementia. However, further research is needed to clarify the results of sensitivity analyses.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Juan Luis Delgado-Gallegos, Gerardo R. Padilla-Rivas, Erika Zuniga-Violante, Gener Aviles-Rodriguez, Daniel Arellanos-Soto, Hector Franco Villareal, Maria de los Angeles Cosio-Leon, Gerardo Salvador Romo-Cardenas, Jose Francisco Islas
Summary: The study in Mexico on academic professionals during the COVID-19 quarantine showed significant statistical correlations among many variables, with perceived stress and anxiety falling mainly in the Absent to Mild category, while the danger section of the ACSS fell into the Moderate category. The high level of resilience generated during the quarantine appears to be a predictor of how well academic professionals have adapted to cope with stress.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Gastroenterology & Hepatology
Paulina Delgado-Gonzalez, Carlos A. Gonzalez-Villarreal, Jorge A. Roacho-Perez, Adriana G. Quiroz-Reyes, Jose Francisco Islas, Juan Luis Delgado-Gallegos, Daniel Arellanos-Soto, Kame A. Galan-Huerta, Elsa N. Garza-Trevino
Summary: Infection by SARS-CoV-2 can lead to GI symptoms and affect the progression of COVID-19, with dysbiosis of intestinal microbiota observed in severe cases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Virology
Natalia Martinez-Acuna, Diana Minerva Avalos-Nolazco, Diana Raquel Rodriguez-Rodriguez, Cynthia Gabriela Martinez-Liu, Kame Alberto Galan-Huerta, Gerardo Raymundo Padilla-Rivas, Javier Ramos-Jimenez, Sergio Ayala-de-la-Cruz, Eduardo Cienfuegos-Pecina, Erik Alejandro Diaz-Chuc, Rogelio Cazares-Tamez, Amador Flores-Arechiga, Fernando Perez-Chavez, Daniel Arellanos-Soto, Sonia Amelia Lozano-Sepulveda, Elvira Garza-Gonzalez, Consuelo Trevino-Garza, Roberto Montes-de-Oca-Luna, Aurora Beatriz Lee-Gonzalez, Manuel Enrique de-la-O-Cavazos, Ana Maria Rivas-Estilla
Summary: The study investigated the seroprevalence of anti-SARS-CoV-2 antibodies in blood donors in Nuevo Leon, Mexico during 2020, showing a growing trend of seroprevalence over time associated with asymptomatic infections. Donors aged 18-49 were more likely to be seropositive, and females had a 1.46-fold higher prevalence compared to males. The majority of SARS-CoV-2 cases were recorded in Monterrey city.
Review
Genetics & Heredity
Oscar Cienfuegos-Jimenez, Eduardo Vazquez-Garza, Augusto Rojas-Martinez
Summary: The Chimeric Antigen Receptor (CAR) technology is a powerful tool in synthetic biology, with the potential to be applied in T and NK cells. While CAR T cell therapy has shown success in clinical trials, there are still challenges to address regarding safety and long-term efficacy. NK cells, with their intrinsic advantages over T cells, offer a promising alternative for treating tumors. Early clinical trials suggest that CAR NK cells may have improved safety profiles and can be used off-the-shelf due to their HLA independence. However, more data is needed in this field. Combining NK cell therapy with immunological checkpoint inhibitors and genetic circuits may further enhance its effectiveness. This review provides an overview of CAR technology for modifying NK cells and its translation from preclinical studies to early clinical trials in immunotherapy.
CURRENT GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Raquel Cruz, Silvia Diz-de Almeida, Miguel Lopez de Heredia, Ines Quintela, Francisco C. Ceballos, Guillermo M. Lorenzo-Salazar, Rafaela Gonzalez-Montelongo, Manuela Gago-Dominguez, Marta Sevilla Porras, Jair Antonio Tenorio Castano, Julian Nevado, Jose Maria Aguado, Carlos Aguilar, Sergio Aguilera-Albesa, Virginia Almadana, Berta Almoguera, Nuria Alvarez, Alvaro Andreu-Bernabeu, Eunate Arana-Arri, Celso Arango, Maria J. Arranz, Maria-Jesus Artiga, Raul C. Baptista-Rosas, Maria Barreda-Sanchez, Moncef Belhassen-Garcia, Joao F. Bezerra, Marcos A. C. Bezerra, Lucia Boix-Palop, Maria Brion, Ramon Brugada, Matilde Bustos, Enrique J. Calderon, Cristina Carbonell, Luis Castano, Jose E. Castelao, Rosa Conde-Vicente, M. Lourdes Cordero-Lorenzana, Jose L. Cortes-Sanchez, Marta Corton, M. Teresa Darnaude, Alba De Martino-Rodriguez, Victor del Campo-Perez, Aranzazu Diaz de Bustamante, Elena Dominguez-Garrido, Andre D. Luchessi, Rocio Eiros, Gladys Mercedes Estigarribia Sanabria, Maria Carmen Farinas, Uxia Fernandez-Robelo, Amanda Fernandez-Rodriguez, Tania Fernandez-Villa, Belen Gil-Fournier, Javier Gomez-Arrue, Beatriz Gonzalez Alvarez, Fernan Gonzalez Bernaldo de Quiros, Javier Gonzalez-Penas, Juan F. Gutierrez-Bautista, Maria Jose Herrero, Antonio Herrero-Gonzalez, Maria A. Jimenez-Sousa, Maria Claudia Lattig, Anabel Liger Borja, Rosario Lopez-Rodriguez, Esther Mancebo, Caridad Martin-Lopez, Vicente Martin, Oscar Martinez-Nieto, Iciar Martinez-Lopez, Michel F. Martinez-Resendez, Angel Martinez-Perez, Juliana F. Mazzeu, Eleuterio Merayo Macias, Pablo Minguez, Victor Moreno Cuerda, Vivian N. Silbiger, Silviene F. Oliveira, Eva Ortega-Paino, Mara Parellada, Estela Paz-Artal, Ney P. C. Santos, Patricia Perez-Matute, Patricia Perez, M. Elena Perez-Tomas, Teresa Perucho, Mel Lina Pinsach-Abuin, Ericka N. Pompa-Mera, Gloria L. Porras-Hurtado, Aurora Pujol, Soraya Ramiro Leon, Salvador Resino, Marianne R. Fernandes, Emilio Rodriguez-Ruiz, Fernando Rodriguez-Artalejo, Jose A. Rodriguez-Garcia, Francisco Ruiz Cabello, Javier Ruiz-Hornillos, Pablo Ryan, Jose Manuel Soria, Juan Carlos Souto, Eduardo Tamayo, Alvaro Tamayo-Velasco, Juan Carlos Taracido-Fernandez, Alejandro Teper, Lilian Torres-Tobar, Miguel Urioste, Juan Valencia-Ramos, Zuleima Yanez, Ruth Zarate, Tomoko Nakanishi, Sara Pigazzini, Frauke Degenhardt, Guillaume Butler-Laporte, Douglas Maya-Miles, Luis Bujanda, Youssef Bouysran, Adriana Palom, David Ellinghaus, Manuel Martinez-Bueno, Selina Rolker, Sara Amitrano, Luisa Roade, Francesca Fava, Christoph D. Spinner, Daniele Prati, David Bernardo, Federico Garcia, Gilles Darcis, Israel Fernandez-Cadenas, Jan Cato Holter, Jesus M. Banales, Robert Frithiof, Stefano Duga, Rosanna Asselta, Alexandre C. Pereira, Manuel Romero-Gomez, Beatriz Nafria-Jimenez, Johannes R. Hov, Isabelle Migeotte, Alessandra Renieri, Anna M. Planas, Kerstin U. Ludwig, Maria Buti, Souad Rahmouni, Marta E. Alarcon-Riquelme, Eva C. Schulte, Andre Franke, Tom H. Karlsen, Luca Valenti, Hugo Zeberg, Brent Richards, Andrea Ganna, Merce Boada, Itziar de Rojas, Agustin Ruiz, Pascual Sanchez-Juan, Luis Miguel Real, Encarna Guillen-Navarro, Carmen Ayuso, Anna Gonzalez-Neira, Jose A. Riancho, Augusto Rojas-Martinez, Carlos Flores, Pablo Lapunzina, Angel Carracedo
Summary: In this study, we identified new candidate genes for COVID-19 severity and provided evidence for genetic disparities among sexes.
HUMAN MOLECULAR GENETICS
(2022)
Article
Genetics & Heredity
Gerardo J. Alanis-Funes, Saul Lira-Albarran, Jesus Hernandez-Perez, Mario A. Garza-Elizondo, Rocio Ortiz-Lopez, Cesar Elizondo, Augusto Rojas-Martinez, Rocio A. Chavez-Santoscoy, Claudia Rangel-Escareno
Summary: Currently, there is no established genetic basis to differentiate hypermobility spectrum disorders (HSD) from hypermobile Ehlers-Danlos syndrome (hEDS). This study used whole-exome sequencing to identify DNA mutations in patients diagnosed with generalized HSD. Three genes (MUC3A, RHBG, and ZNF717) were found to be mutated in all five patients evaluated. Functional enrichment analysis revealed the extracellular matrix (ECM) structural constituent as the primary overrepresented molecular function. Comparison with other studies supported the hypothesis of two distinct diseases sharing a common genetic background. Five potential biomarkers for HSD were identified.
Article
Genetics & Heredity
R. Villafuerte-De la Cruz, O. F. Chacon-Camacho, A. C. Rodriguez-Martinez, N. Xilotl-De Jesus, R. Arce-Gonzalez, C. Rodriguez-De la Torre, J. E. Valdez-Garcia, A. Rojas-Martinez, J. C. Zenteno
Summary: This study describes an IRD patient with ABCA4 and USH2A pathogenic biallelic mutations resulting from paternal uniparental disomy on chromosome 1. This is the first known case of a patient with confirmed UPD for two recessively mutated IRD genes, expanding on the genetic heterogeneity of IRDs and highlighting the importance of UPD as a mechanism of autosomal recessive disease in non-consanguineous parents.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Analytical
Cynthia Martinez-Liu, Carlos Machain-Williams, Natalia Martinez-Acuna, Sonia Lozano-Sepulveda, Kame Galan-Huerta, Daniel Arellanos-Soto, Mayra Melendez-Villanueva, Diana Avalos-Nolazco, Katya Perez-Ibarra, Sergio Galindo-Rodriguez, Aurora de Jesus Garza-Juarez, Ana Maria Rivas-Estilla
Summary: In this study, a biosensor based on gold nanoparticles and antibody was designed for the detection of dengue virus in vitro, showing significant differences in size and characteristics between different conjugates and naked AuNPs. The biosensor was further used in the development of a lateral flow assay for detecting flavivirus envelope protein in isolated DENV samples, with promising results for future dengue detection.
Article
Nutrition & Dietetics
Alberto Camacho-Morales, Andrea Caballero-Benitez, Enrique Vazquez-Cruz, Roger Maldonado-Ruiz, Marcela Cardenas-Tueme, Augusto Rojas-Martinez, Diana Caballero-Hernandez
Summary: Maternal overnutrition and exposure to high-energy diets during pregnancy can lead to metabolic and immune alterations in offspring, including obesity and inflammation. This study suggests that maternal nutritional programming increases susceptibility to ghrelin-induced overeating in offspring, particularly under chronic stress conditions. The findings also indicate a relationship between cortisol accumulation and ghrelin sensitivity in the offspring.
NUTRITION RESEARCH
(2022)
Review
Genetics & Heredity
Laura Elena Cordova-Davalos, Alicia Hernandez-Mercado, Claudia Berenice Barron-Garcia, Augusto Rojas-Martinez, Mariela Jimenez, Eva Salinas, Daniel Cervantes-Garcia
Summary: Variations in key genes affect the development of innate immune response against respiratory syncytial virus (RSV). Understanding these gene variations provides crucial information for understanding viral infection mechanisms, vaccine development, and pharmacological treatments.
Article
Multidisciplinary Sciences
Jose Antonio Cruz-Cardenas, Michelle Gutierrez, Alejandra Lopez-Arredondo, Julio Enrique Castaneda-Delgado, Augusto Rojas-Martinez, Yukio Nakamura, Jose Antonio Enciso-Moreno, Laura A. Palomares, Marion E. G. Brunck
Summary: This study describes the development of a BSL-2 safe functional assay using pseudoviral particles in Mexico to measure neutralizing antibodies (NAbs). The assay showed high sensitivity, specificity, and accuracy, making it a valuable method for detecting NAbs in limited resource settings.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Humberto Garcia-Ortiz, Francisco Barajas-Olmos, Cecilia Contreras-Cubas, Austin W. Reynolds, Marlen Flores-Huacuja, Meradeth Snow, Jazmin Ramos-Madrigal, Elvia Mendoza-Caamal, Paulina Baca, Tomas A. Lopez-Escobar, Deborah A. Bolnick, Silvia Esperanza Flores-Martinez, Rocio Ortiz-Lopez, Aleksandar David Kostic, Jose Rafael Villafan-Bernal, Carlos Galaviz-Hernandez, Federico Centeno-Cruz, Alejandra Guadalupe Garcia-Zapien, Tulia Monge-Cazares, Blanca Patricia Lazalde-Ramos, Francisco Loeza-Becerra, Maria Del Carmen Abrahantes-Perez, Hector Rangel-Villalobos, Martha Sosa-Macias, Augusto Rojas-Martinez, Angelica Martinez-Hernandez, Lorena Orozco
Summary: This study investigates how selective pressures have shaped the genetic structure of Native American populations. The findings suggest that immunological and metabolic pressures are major drivers of human adaptation, and the coevolution with gut microbiome is also crucial.
Article
Oncology
Gerardo I. Magallanes-Garza, Sandra K. Santuario-Facio, Saul Lira-Albarran, Arlina F. Varela-Varela, Servando Cardona-Huerta, Pablo Ruiz-Flores, Jorge Haro-Santa-Cruz, Yadira X. Perez-Paramo, Gabriela Sofia Gomez-Macias, Daniel Davila-Gonzalez, Javier Valero-Gomez, Gissela Borrego-Soto, Augusto Rojas-Martinez, Rocio Ortiz-Lopez
Summary: This study found that the downregulation of NUSAP1 and PCLAF in breast cancer patients after neoadjuvant chemotherapy is associated with therapeutic response and patient survival.
JOURNAL OF ONCOLOGY
(2022)
Article
Genetics & Heredity
Nina Ishorst, Leonie Henschel, Frederic Thieme, Dmitriy Drichel, Sugirthan Sivalingam, Sarah L. Mehrem, Ariane C. Fechtner, Julia Fazaal, Julia Welzenbach, Andre Heimbach, Carlo Maj, Oleg Borisov, Jonas Hausen, Ruth Raff, Alexander Hoischen, Michael Dixon, Alvaro Rada-Iglesias, Michaela Bartusel, Augusto Rojas-Martinez, Khalid Aldhorae, Bert Braumann, Teresa Kruse, Christian Kirschneck, Gerrit Spanier, Heiko Reutter, Stefanie Nowak, Lina Goelz, Michael Knapp, Andreas Buness, Peter Krawitz, Markus M. Noethen, Michael Nothnagel, Tim Becker, Kerstin U. Ludwig, Elisabeth Mangold
Summary: This study investigates the genetic mechanisms of nonsyndromic cleft lip with/without cleft palate (nsCL/P) and identifies new candidate genes through the detection of highly penetrant de novo variants (DNVs). By conducting a series of analyses and validations on a discovery sample of 50 nsCL/P patient/parent-trios, MDN1 and PAXIP1 were identified as top candidate genes.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Review
Nursing
Yuliana Vera-Alanis, Daysi Aranda-Sanchez, Guillermo Cano-Verdugo, Pedro Gonzalez-Angulo, Cynthia Berenice Rueda-Sanchez, Augusto Rojas-Martinez
Summary: During the COVID-19 pandemic, nurses face a higher risk of infection and mortality. This study reviewed information on the mortality of nursing personnel from different countries. The results showed that nursing personnel had a higher mortality rate compared to physicians and other healthcare workers. The average age of deceased nurses was 43 years, with higher rates among men. Inadequate planning and lack of personal protective equipment were identified as contributing factors to the contagion and deaths.