“LRRK2: Autophagy and Lysosomal Activity”

Lysosome and Inflammatory Defects in GBA1 ‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition

(2020) Anwesha Sanyal et al.   MOVEMENT DISORDERS

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

(2019) Angelique di Domenico et al.   Stem Cell Reports

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

(2019) Michael X. Henderson et al.   Acta Neuropathologica Communications

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons

(2019) Federico Zambon et al.   HUMAN MOLECULAR GENETICS

LRRK2 links genetic and sporadic Parkinson's disease

(2019) Jillian H. Kluss et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

(2019) Philip Wing-Lok Ho et al.   Autophagy

LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

(2019) Tiago Fleming Outeiro et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function

(2019) Rebecca Wallings et al.   HUMAN MOLECULAR GENETICS

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

(2019) Jonas Walter et al.   Stem Cell Reports

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2

(2019) Natalie Connor-Robson et al.   NEUROBIOLOGY OF DISEASE

LRRK2 regulation of immune-pathways and inflammatory disease

(2019) Rebecca L. Wallings et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Physiological and pathological roles of LRRK2 in the nuclear envelope integrity

(2019) Vered Shani et al.   HUMAN MOLECULAR GENETICS

Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia

(2019) Cornelis Blauwendraat et al.   BRAIN

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

(2019) Daniel C. Berwick et al.   Molecular Neurodegeneration

LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

(2019) Daniel Ysselstein et al.   Nature Communications

P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity

(2018) Alexia F. Kalogeropulou et al.   BIOCHEMICAL JOURNAL

mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition

(2018) Claudia Manzoni et al.   BIOSCIENCE REPORTS

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

(2018) Anetta Härtlova et al.   EMBO JOURNAL

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S-Parkinson’s disease

(2018) Diana Luz Juárez-Flores et al.   Journal of Translational Medicine

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

(2018) Jason Schapansky et al.   NEUROBIOLOGY OF DISEASE

Suppression of autophagy in the brain of transgenic mice with overexpression of А53Т-mutant α-synuclein as an early event at synucleinopathy progression

(2018) Alexander B. Pupyshev et al.   NEUROSCIENCE LETTERS

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease

(2018) Xian-Si Zeng et al.   Frontiers in Aging Neuroscience

Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson’s disease brains with Lewy body pathology

(2018) Adamantios Mamais et al.   BRAIN RESEARCH

A new hypothesis for Parkinson’s disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics

(2018) Julia Obergasteiger et al.   Molecular Neurodegeneration

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

(2018) Tomoya Eguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

(2018) Eun-Jin Bae et al.   Nature Communications

LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase

(2018) Dong Hwan Ho et al.   CELL BIOCHEMISTRY AND FUNCTION

Carriers of both GBA and LRRK2 mutations, compared to carriers of either, in Parkinson's disease: Risk estimates and genotype-phenotype correlations

(2018) Gilad Yahalom et al.   PARKINSONISM & RELATED DISORDERS

Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis

(2018) Michaela E. Johnson et al.   TRENDS IN NEUROSCIENCES

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease

(2017) Yumiko V. Taguchi et al.   JOURNAL OF NEUROSCIENCE

Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons

(2017) Ping-Yue Pan et al.   JOURNAL OF NEUROSCIENCE

Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature

(2017) Susanne A. Schneider et al.   MOVEMENT DISORDERS

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel

(2017) Minghui Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice

(2017) Emilie Giaime et al.   NEURON

Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel

(2017) Minghui Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in Neurotrauma

(2017) Hisham Bahmad et al.   Frontiers in Molecular Neuroscience

Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells

(2016) You-fa Zhou et al.   ACTA PHARMACOLOGICA SINICA

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein

(2016) G. Guaitoli et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease

(2016) M. R. Cookson   BIOCHEMICAL SOCIETY TRANSACTIONS

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinsons Disease

(2016) Pilar Rivero-Ríos et al.   Current Neuropharmacology

LRRK2BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function

(2016) Max Sloan et al.   HUMAN MOLECULAR GENETICS

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

(2016) Senthilkumar S. Karuppagounder et al.   JOURNAL OF CHEMICAL NEUROANATOMY

G2019S-LRRK2 Expression Augments  -Synuclein Sequestration into Inclusions in Neurons

(2016) L. A. Volpicelli-Daley et al.   JOURNAL OF NEUROSCIENCE

LRRK2 interferes with aggresome formation for autophagic clearance

(2016) Yeojin Bang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

(2016) Hugo J.R. Fernandes et al.   Stem Cell Reports

Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy

(2016) Sangwook Park et al.   PLoS One

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

(2016) Claudia Manzoni et al.   Scientific Reports

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

(2015) Ziv Gan-Or et al.   Autophagy

Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy

(2015) Yu-Chin Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations

(2015) Roy N. Alcalay et al.   BRAIN

Cellular processes associated with LRRK2 function and dysfunction

(2015) Rebecca Wallings et al.   FEBS Journal

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

(2015) Anastasia G. Henry et al.   HUMAN MOLECULAR GENETICS

An early endosome regulator, Rab5b, is an LRRK2 kinase substrate

(2015) Hye Jin Yun et al.   JOURNAL OF BIOCHEMISTRY

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

Mutations in LRRK2 potentiate age-related impairment of autophagic flux

(2015) Shamol Saha et al.   Molecular Neurodegeneration

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

(2015) M. Yue et al.   NEUROBIOLOGY OF DISEASE

Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers

(2015) M. Caesar et al.   NEUROSCIENCE

The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson’s disease

(2015) J. Schapansky et al.   NEUROSCIENCE

Cysteine cathepsins are essential in lysosomal degradation of α-synuclein

(2015) Ryan P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease

(2015) Ting Wang et al.   Frontiers in Neuroscience

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

(2015) Yong-Bo Hu et al.   Translational Neurodegeneration

Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

(2014) M. W. Dodson et al.   Disease Models & Mechanisms

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

(2014) H. J. Cho et al.   EMBO JOURNAL

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

(2014) J. Schapansky et al.   HUMAN MOLECULAR GENETICS

Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

(2014) L. N. Hockey et al.   JOURNAL OF CELL SCIENCE

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

(2014) Loukia Parisiadou et al.   NATURE NEUROSCIENCE

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

(2014) Elpida Tsika et al.   NEUROBIOLOGY OF DISEASE

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling

(2014) S Saez-Atienzar et al.   Cell Death & Disease

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

(2014) Vinay K. Godena et al.   Nature Communications

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

Glucocerebrosidase mutations and the pathogenesis of Parkinson disease

(2013) Michelle S. Beavan et al.   ANNALS OF MEDICINE

Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

(2013) Claudia Manzoni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of LRRK2 kinase activity stimulates macroautophagy

(2013) Claudia Manzoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Ca2+–Sensor Proteins in the Autophagic and Endocytic Traffic

(2013) Ghita Ghislat et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The hallmarks of Parkinson's disease

(2013) Paul M. A. Antony et al.   FEBS Journal

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

(2013) Yu-Chin Su et al.   HUMAN MOLECULAR GENETICS

The genetics of Parkinson's disease: Progress and therapeutic implications

(2013) Andrew B. Singleton et al.   MOVEMENT DISORDERS

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

(2012) José M. Bravo-San Pedro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

(2012) I. Ahmed et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

(2012) Maria Xilouri et al.   MOLECULAR NEUROBIOLOGY

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

(2011) M. W. Dodson et al.   HUMAN MOLECULAR GENETICS

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Autophagy in immunity and cell-autonomous defense against intracellular microbes

(2011) Vojo Deretic   IMMUNOLOGICAL REVIEWS

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Genetic Analysis of Pathways to Parkinson Disease

(2010) John Hardy   NEURON

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease

(2009) Shinji Higashi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY