LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
出版年份 2019 全文链接
标题
LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
作者
关键词
-
出版物
Nature Communications
Volume 10, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-12-13
DOI
10.1038/s41467-019-13413-w
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
- (2019) Jianbin Zheng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Emerging links between pediatric lysosomal storage diseases and adult parkinsonism
- (2019) Daniel Ysselstein et al. MOVEMENT DISORDERS
- LRRK2 Phosphorylation: Behind the Scenes
- (2018) Tina De Wit et al. NEUROSCIENTIST
- LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease
- (2018) Maria Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
- (2018) Michael X. Henderson et al. Acta Neuropathologica Communications
- LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
- (2018) Tomoya Eguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LRRK2 activation in idiopathic Parkinson’s disease
- (2018) Roberto Di Maio et al. Science Translational Medicine
- Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s disease
- (2018) Farzaneh Atashrazm et al. Scientific Reports
- Carriers of both GBA and LRRK2 mutations, compared to carriers of either, in Parkinson's disease: Risk estimates and genotype-phenotype correlations
- (2018) Gilad Yahalom et al. PARKINSONISM & RELATED DISORDERS
- LRRK2 interacts with ATM and regulates Mdm2–p53 cell proliferation axis in response to genotoxic stress
- (2017) Zhongcan Chen et al. HUMAN MOLECULAR GENETICS
- A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
- (2017) Diana Chang et al. NATURE GENETICS
- Selective neuronal vulnerability in Parkinson disease
- (2017) D. James Surmeier et al. NATURE REVIEWS NEUROSCIENCE
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- Glucocerebrosidase Mutations in Parkinson Disease
- (2017) Grace O’Regan et al. Journal of Parkinsons Disease
- α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
- (2016) Joseph R. Mazzulli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations
- (2015) Roy N. Alcalay et al. BRAIN
- Cellular processes associated with LRRK2 function and dysfunction
- (2015) Rebecca Wallings et al. FEBS Journal
- Association of LRRK2 and GBA mutations in a Brazilian family with Parkinson's disease
- (2015) Mariana Spitz et al. PARKINSONISM & RELATED DISORDERS
- LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?
- (2014) Isabella Russo et al. Journal of Neuroinflammation
- The role of the LRRK2 gene in Parkinsonism
- (2014) Jie-Qiong Li et al. Molecular Neurodegeneration
- Interaction of LRRK2 with kinase and GTPase signaling cascades
- (2014) Joon Y. Boon et al. Frontiers in Molecular Neuroscience
- The link between the GBA gene and parkinsonism
- (2012) Ellen Sidransky et al. LANCET NEUROLOGY
- Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies
- (2012) Erwan Bezard et al. MOVEMENT DISORDERS
- The glucocerobrosidase E326K variant predisposes to Parkinson's disease, but does not cause Gaucher's disease
- (2012) Raquel Duran et al. MOVEMENT DISORDERS
- Meta-analysis of Parkinson's Disease: Identification of a novel locus, RIT2
- (2011) Nathan Pankratz et al. ANNALS OF NEUROLOGY
- Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
- (2011) Sonja Kriks et al. NATURE
- Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
- (2011) Xianming Deng et al. Nature Chemical Biology
- Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease
- (2008) Saskia Biskup et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More