标题
Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
作者
关键词
-
出版物
HUMAN MOLECULAR GENETICS
Volume 23, Issue 16, Pages 4201-4214
出版商
Oxford University Press (OUP)
发表日期
2014-03-29
DOI
10.1093/hmg/ddu138
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis
- (2014) Pika Miklavc et al. PLoS One
- LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease
- (2014) Cheol Hwan Hyun et al. Experimental Neurobiology
- Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1
- (2013) Gregory C. Luerman et al. JOURNAL OF NEUROCHEMISTRY
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease
- (2013) Kurt M. Lucin et al. NEURON
- Guidelines for the use and interpretation of assays for monitoring autophagy
- (2012) Daniel J. Klionsky et al. Autophagy
- GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor
- (2012) Alastair D. Reith et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway
- (2012) José M. Bravo-San Pedro et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
- (2012) Adriana Sánchez-Danés et al. EMBO Molecular Medicine
- Impaired autophagy leads to abnormal dendritic cell–epithelial cell interactions
- (2012) Caterina Strisciuglio et al. Journal of Crohns & Colitis
- LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein
- (2012) Daniel F Marker et al. Journal of Neuroinflammation
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
- (2012) Youren Tong et al. Molecular Neurodegeneration
- Microglial Activation in Neuroinflammation: Implications for the Etiology of Neurodegeneration
- (2012) Yoko S. Kaneko et al. Neurodegenerative Diseases
- LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis
- (2012) Samer Matta et al. NEURON
- The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling
- (2012) Nicolas Dzamko et al. PLoS One
- Brain Penetrant LRRK2 Inhibitor
- (2012) Hwan Geun Choi et al. ACS Medicinal Chemistry Letters
- Crohn disease: A current perspective on genetics, autophagy and immunity
- (2011) Thaddeus S. Stappenbeck et al. Autophagy
- Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form
- (2011) Genta Ito et al. BIOCHEMICAL JOURNAL
- Autophagy and innate immunity ally against bacterial invasion
- (2011) Lorenzo Galluzzi et al. EMBO JOURNAL
- Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
- (2011) M. W. Dodson et al. HUMAN MOLECULAR GENETICS
- Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
- (2011) Patricia Gómez-Suaga et al. HUMAN MOLECULAR GENETICS
- Autophagy in immunity and cell-autonomous defense against intracellular microbes
- (2011) Vojo Deretic IMMUNOLOGICAL REVIEWS
- Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis
- (2011) Junji Umeno et al. INFLAMMATORY BOWEL DISEASES
- Rac1 Protein Rescues Neurite Retraction Caused by G2019S Leucine-rich Repeat Kinase 2 (LRRK2)
- (2011) Diane Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities
- (2011) Philip J. Webber et al. JOURNAL OF MOLECULAR BIOLOGY
- Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
- (2011) Mansoureh Hakimi et al. JOURNAL OF NEURAL TRANSMISSION
- The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
- (2011) Zhihua Liu et al. NATURE IMMUNOLOGY
- Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation
- (2011) Jonathan Thévenet et al. PLoS One
- Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
- (2011) Smita Majumder et al. PLoS One
- The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation
- (2011) David G. McEwan et al. TRENDS IN CELL BIOLOGY
- Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization
- (2010) Nicolas Dzamko et al. BIOCHEMICAL JOURNAL
- 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
- (2010) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation
- (2010) Zdenek Berger et al. BIOCHEMISTRY
- Methods in Mammalian Autophagy Research
- (2010) Noboru Mizushima et al. CELL
- Role of autophagy in heart failure associated with aging
- (2010) Guido R. Y. De Meyer et al. HEART FAILURE REVIEWS
- The intracellular dynamic of protein palmitoylation
- (2010) Christine Salaun et al. JOURNAL OF CELL BIOLOGY
- LRRK2 Is Involved in the IFN- Response and Host Response to Pathogens
- (2010) A. Gardet et al. JOURNAL OF IMMUNOLOGY
- Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease
- (2010) Jérémie Vitte et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3
- (2010) C.-H. Lin et al. JOURNAL OF NEUROSCIENCE
- Regulation of Mammalian Autophagy in Physiology and Pathophysiology
- (2010) Brinda Ravikumar et al. PHYSIOLOGICAL REVIEWS
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
- (2009) Javier Alegre-Abarrategui et al. HUMAN MOLECULAR GENETICS
- Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization
- (2009) Saurabh Sen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells
- (2009) T. Takenouchi et al. JOURNAL OF IMMUNOLOGY
- Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?
- (2009) Frank Gillardon JOURNAL OF NEUROCHEMISTRY
- Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease
- (2009) Shinji Higashi et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
- (2009) L. Parisiadou et al. JOURNAL OF NEUROSCIENCE
- Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)
- (2009) E. Andres-Mateos et al. JOURNAL OF NEUROSCIENCE
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
- (2009) Malú G. Tansey et al. NEUROBIOLOGY OF DISEASE
- Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
- (2008) Yuzuru Imai et al. EMBO JOURNAL
- LRRK2 regulates synaptic vesicle endocytosis
- (2008) Narae Shin et al. EXPERIMENTAL CELL RESEARCH
- The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation
- (2008) Elisa Greggio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
- (2008) Edward D. Plowey et al. JOURNAL OF NEUROCHEMISTRY
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
- (2008) Koji Yamanaka et al. NATURE NEUROSCIENCE
- CSS-Palm 2.0: an updated software for palmitoylation sites prediction
- (2008) J. Ren et al. PROTEIN ENGINEERING DESIGN & SELECTION
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