标题
Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease
作者
关键词
-
出版物
Frontiers in Aging Neuroscience
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-04-17
DOI
10.3389/fnagi.2018.00109
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
- (2018) Georgia Minakaki et al. Autophagy
- Cholesterol and multilamellar bodies: Lysosomal dysfunction in GBA-Parkinson disease
- (2018) Patricia García-Sanz et al. Autophagy
- RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress
- (2018) Zhao Zhang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease
- (2018) Ashley S. Harms et al. EXPERIMENTAL NEUROLOGY
- Selective α-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson’s Disease
- (2018) Diana Alarcón-Arís et al. MOLECULAR THERAPY
- Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal
- (2018) Shi Zhang et al. NEUROBIOLOGY OF AGING
- Suppression of autophagy in the brain of transgenic mice with overexpression of А53Т-mutant α-synuclein as an early event at synucleinopathy progression
- (2018) Alexander B. Pupyshev et al. NEUROSCIENCE LETTERS
- Glucocerebrosidase and Parkinson Disease: Molecular, Clinical, and Therapeutic Implications
- (2018) Roberta Balestrino et al. NEUROSCIENTIST
- GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers
- (2018) Sangjune Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Urate promotes SNCA/α-synuclein clearance via regulating mTOR-dependent macroautophagy
- (2017) Yu-Lan Sheng et al. EXPERIMENTAL NEUROLOGY
- A peptide disrupting the D2R-DAT interaction protects against dopamine neurotoxicity
- (2017) Ping Su et al. EXPERIMENTAL NEUROLOGY
- Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
- (2017) Andrew B. West EXPERIMENTAL NEUROLOGY
- Identification of potential therapeutic compounds for Parkinson's disease using Drosophila and human cell models
- (2017) Francisco José Sanz et al. FREE RADICAL BIOLOGY AND MEDICINE
- G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain
- (2017) An Phu Tran Nguyen et al. HUMAN MOLECULAR GENETICS
- LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson’s disease
- (2017) Evan H Howlett et al. HUMAN MOLECULAR GENETICS
- Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons
- (2017) Sabrina M Heman-Ackah et al. HUMAN MOLECULAR GENETICS
- Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease
- (2017) Zhan-ying Hu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin
- (2017) Bin Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkinson disease–associatedLRRK2 G2019Stransgene disrupts marrow myelopoiesis and peripheral Th17 response
- (2017) Jeongho Park et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation
- (2017) Sylvia Torres-Odio et al. Journal of Neuroinflammation
- Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease
- (2017) Yumiko V. Taguchi et al. JOURNAL OF NEUROSCIENCE
- Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration inC. elegansModels of Parkinson's Disease
- (2017) Bryan A. Martinez et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants
- (2017) Manish Verma et al. JOURNAL OF NEUROSCIENCE
- Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons
- (2017) Ping-Yue Pan et al. JOURNAL OF NEUROSCIENCE
- MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation
- (2017) Seongmi Lee et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Neuroprotective effect of chondroitin sulfate on SH-SY5Y cells overexpressing wild-type or A53T mutant α-synuclein
- (2017) Chuanxia Ju et al. Molecular Medicine Reports
- The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity
- (2017) Maya Ando et al. Molecular Neurodegeneration
- Alpha-synuclein triggers T-cell response. Is Parkinson's disease an autoimmune disorder?
- (2017) Sara Bandres-Ciga et al. MOVEMENT DISORDERS
- Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients
- (2017) Lucilla Parnetti et al. MOVEMENT DISORDERS
- N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease
- (2017) Patricia García-Sanz et al. MOVEMENT DISORDERS
- Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature
- (2017) Susanne A. Schneider et al. MOVEMENT DISORDERS
- Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model
- (2017) Tetsuhiro Kikuchi et al. NATURE
- T cells from patients with Parkinson’s disease recognize α-synuclein peptides
- (2017) David Sulzer et al. NATURE
- Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model
- (2017) Pia Rivetti di Val Cervo et al. NATURE BIOTECHNOLOGY
- Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
- (2017) Danielle E Mor et al. NATURE NEUROSCIENCE
- Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration
- (2017) Itzia Jimenez-Ferrer et al. NEUROBIOLOGY OF DISEASE
- Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease
- (2017) Alice Biosa et al. NEUROBIOLOGY OF DISEASE
- TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease
- (2017) Seong Su Kang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deconstructing behavioral neuropharmacology with cellular specificity
- (2017) Brenda C. Shields et al. SCIENCE
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
- (2017) Shuchi Mittal et al. SCIENCE
- VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2
- (2017) Seung Pil Yun et al. Cell Death & Disease
- Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy
- (2017) Jia Liu et al. Cell Death & Disease
- Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy
- (2017) Wenming Li et al. Nature Communications
- PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
- (2017) En Huang et al. Nature Communications
- Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models
- (2017) Jason F. Cooper et al. Scientific Reports
- Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice
- (2017) Mantia Karampetsou et al. Scientific Reports
- S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models
- (2017) Chang-Ki Oh et al. Cell Reports
- DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy
- (2017) Chuan-Ying Xu et al. Frontiers in Aging Neuroscience
- 68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment
- (2017) Joseph M. Thomas et al. Frontiers in Aging Neuroscience
- Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
- (2017) Atul Kumar et al. eLife
- Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
- (2017) Martin Steger et al. eLife
- LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
- (2017) Hien Tran Zhao et al. Molecular Therapy-Nucleic Acids
- Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications
- (2017) Fei Gao et al. Frontiers in Neurology
- Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?
- (2017) Junichi Matsumoto et al. Acta Neuropathologica Communications
- Role of LRRK2 in the regulation of dopamine receptor trafficking
- (2017) Mauro Rassu et al. PLoS One
- Proteasome impairment by α-synuclein
- (2017) Lisa Zondler et al. PLoS One
- Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease
- (2017) Fang Fang et al. Scientific Reports
- Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s disease
- (2017) Simone Bido et al. Scientific Reports
- An updated review of Parkinson's disease genetics and clinicopathological correlations
- (2016) M. Ferreira et al. ACTA NEUROLOGICA SCANDINAVICA
- Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice
- (2016) Anna Migdalska-Richards et al. ANNALS OF NEUROLOGY
- Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons
- (2016) Anne Grünewald et al. ANNALS OF NEUROLOGY
- Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders
- (2016) Yu Cai et al. Autophagy
- Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
- (2016) Maria Xilouri et al. Autophagy
- Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation
- (2016) Rebecca J. Mason et al. BIOCHEMISTRY
- Heterozygous PINK1 p.G411S increases risk of Parkinson’s disease via a dominant-negative mechanism
- (2016) Andreas Puschmann et al. BRAIN
- DJ-1 linked parkinsonism (PARK7) is associated with Lewy body pathology
- (2016) Ricardo Taipa et al. BRAIN
- Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
- (2016) Timothy R. Sampson et al. CELL
- Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation
- (2016) Diana Matheoud et al. CELL
- Endoplasmic reticulum and lysosomal Ca2+ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts
- (2016) Bethan S. Kilpatrick et al. CELL CALCIUM
- Long Non-coding RNA HOTAIR Promotes Parkinson';s Disease Induced by MPTP Through up-regulating the Expression of LRRK2
- (2016) Sen Liu et al. CURRENT NEUROVASCULAR RESEARCH
- Beclin1 and HMGB1 ameliorate the α-synuclein-mediated autophagy inhibition in PC12 cells
- (2016) Kaihua Wang et al. Diagnostic Pathology
- Overexpression of DJ-1/PARK7, the Parkinson's disease-related protein, improves mitochondrial function via Akt phosphorylation on threonine 308 in dopaminergic neuron-like cells
- (2016) Yi Zhang et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease
- (2016) Joana Magalhaes et al. HUMAN MOLECULAR GENETICS
- Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation
- (2016) Kyung Ah Han et al. HUMAN MOLECULAR GENETICS
- Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation
- (2016) Jordan Follett et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity
- (2016) Senthilkumar S. Karuppagounder et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Activation of -Glucocerebrosidase Reduces Pathological -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
- (2016) J. R. Mazzulli et al. JOURNAL OF NEUROSCIENCE
- G2019S-LRRK2 Expression Augments -Synuclein Sequestration into Inclusions in Neurons
- (2016) L. A. Volpicelli-Daley et al. JOURNAL OF NEUROSCIENCE
- Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson’s Disease
- (2016) Chien-Wei Feng et al. Marine Drugs
- ER Stress Induced by Tunicamycin Triggers α-Synuclein Oligomerization, Dopaminergic Neurons Death and Locomotor Impairment: a New Model of Parkinson’s Disease
- (2016) Valentín Cóppola-Segovia et al. MOLECULAR NEUROBIOLOGY
- Neuroprotective Effects of a Standardized Flavonoid Extract from Safflower against a Rotenone-Induced Rat Model of Parkinson’s Disease
- (2016) Nuramatjan Ablat et al. MOLECULES
- Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism
- (2016) J. Meiser et al. NEUROBIOLOGY OF DISEASE
- Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson’s disease
- (2016) Joseph C. Gully et al. NEUROSCIENCE LETTERS
- Pathological -synuclein transmission initiated by binding lymphocyte-activation gene 3
- (2016) X. Mao et al. SCIENCE
- Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease
- (2016) I Celardo et al. Cell Death & Disease
- PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control
- (2016) Na Zhuang et al. Cell Death & Disease
- G2385R and I2020T Mutations Increase LRRK2 GTPase Activity
- (2016) Dong Hwan Ho et al. Biomed Research International
- Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease
- (2015) Ziv Gan-Or et al. Autophagy
- Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy
- (2015) Yu-Chin Su et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia
- (2015) Patrick Ejlerskov et al. CELL
- Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, andin Vivo
- (2015) Martial Kamdem Mbefo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model
- (2015) Alevtina D. Zharikov et al. JOURNAL OF CLINICAL INVESTIGATION
- Evaluation of PARKIN gene variants in West Bengal Parkinson’s disease patients
- (2015) Jaya Sanyal et al. JOURNAL OF HUMAN GENETICS
- VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
- (2015) F.-L. Tang et al. JOURNAL OF NEUROSCIENCE
- Structure of the toxic core of α-synuclein from invisible crystals
- (2015) Jose A. Rodriguez et al. NATURE
- Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
- (2015) Wenzhang Wang et al. NATURE MEDICINE
- UDCA exerts beneficial effect on mitochondrial dysfunction inLRRK2G2019Scarriers and in vivo
- (2015) Heather Mortiboys et al. NEUROLOGY
- Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
- (2015) Uma A. Mukherjee et al. PHARMACOLOGY & THERAPEUTICS
- VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function
- (2015) Fu-Lei Tang et al. Cell Reports
- Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease
- (2014) Karen E. Murphy et al. BRAIN
- The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein
- (2014) Riccardo Porcari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction
- (2014) Eric S. Luth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Divergent effects of the H50Q and G51DSNCAmutations on the aggregation of α-synuclein
- (2014) Nicola J. Rutherford et al. JOURNAL OF NEUROCHEMISTRY
- Overexpression of Human E46K Mutant α-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway
- (2014) Jia-Qing Yan et al. MOLECULAR NEUROBIOLOGY
- Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice
- (2014) J. Mark Cooper et al. MOVEMENT DISORDERS
- The Parkinson's Disease-Related Protein DJ-1 Protects Dopaminergic Neurons in vivo and Cultured Cells from Alpha-Synuclein and 6-Hydroxydopamine Toxicity
- (2014) Sara Batelli et al. Neurodegenerative Diseases
- Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders
- (2014) David S. Goldstein et al. PHARMACOLOGY & THERAPEUTICS
- Rifampicin Protects PC12 Cells from Rotenone-Induced Cytotoxicity by Activating GRP78 via PERK-eIF2α-ATF4 Pathway
- (2014) Xiuna Jing et al. PLoS One
- Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
- (2014) P. Valdes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease
- (2014) L Zondler et al. Cell Death & Disease
- MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
- (2014) Carolina Cebrián et al. Nature Communications
- In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila
- (2014) Hua-shan Wang et al. Molecular Brain
- Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson’s disease
- (2013) Heather Mortiboys et al. BRAIN
- The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease
- (2013) Xian-Si Zeng et al. FREE RADICAL BIOLOGY AND MEDICINE
- Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease
- (2013) Eugénie Mutez et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial dysfunction and oxidative stress in Parkinson's disease
- (2013) Sudhakar Raja Subramaniam et al. PROGRESS IN NEUROBIOLOGY
- Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration
- (2012) Fei Yin et al. ANTIOXIDANTS & REDOX SIGNALING
- ER stress inhibits neuronal death by promoting autophagy
- (2012) Antoine Fouillet et al. Autophagy
- Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment
- (2012) Jason R. Cannon et al. EXPERIMENTAL NEUROLOGY
- Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease
- (2012) Michael H. Yan et al. FREE RADICAL BIOLOGY AND MEDICINE
- DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway
- (2012) Joo-Young Im et al. HUMAN MOLECULAR GENETICS
- LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
- (2012) X. Wang et al. HUMAN MOLECULAR GENETICS
- Inactivation ofPink1Genein VivoSensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes,ParkinorDJ-1
- (2012) M. Emdadul Haque et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling
- (2012) Senthil Selvaraj et al. JOURNAL OF CLINICAL INVESTIGATION
- Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease
- (2012) David S. Goldstein et al. JOURNAL OF NEUROCHEMISTRY
- A clinical and family history study of Parkinson's disease in heterozygousglucocerebrosidasemutation carriers
- (2012) Alisdair McNeill et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Endoplasmic Reticulum Stress Is Important for the Manifestations of -Synucleinopathy In Vivo
- (2012) E. Colla et al. JOURNAL OF NEUROSCIENCE
- L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
- (2012) Haigang Ren et al. Molecular Neurodegeneration
- Glucose Regulated Protein 78 Diminishes α-Synuclein Neurotoxicity in a Rat Model of Parkinson Disease
- (2012) Marina S Gorbatyuk et al. MOLECULAR THERAPY
- Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage
- (2012) Michael W.J. Cleeter et al. NEUROCHEMISTRY INTERNATIONAL
- Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia
- (2012) Beomsue Kim et al. PLoS One
- Dopamine Induced Neurodegeneration in a PINK1 Model of Parkinson's Disease
- (2012) Sonia Gandhi et al. PLoS One
- Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons
- (2011) F. H. Sterky et al. HUMAN MOLECULAR GENETICS
- Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model
- (2011) Won-Seok Choi et al. JOURNAL OF CELL BIOLOGY
- Authentically Phosphorylated -Synuclein at Ser129 Accelerates Neurodegeneration in a Rat Model of Familial Parkinson's Disease
- (2011) H. Sato et al. JOURNAL OF NEUROSCIENCE
- Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism
- (2011) Zhaohui Liu et al. PHARMACOLOGICAL RESEARCH
- Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
- (2011) P. M. Rappold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity
- (2010) Sebastian Deeg et al. JOURNAL OF CELL BIOLOGY
- The Genetics of Parkinson Disease
- (2010) Lynn M. Bekris et al. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
- Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism
- (2010) Mali Jiang et al. JOURNAL OF NEUROCHEMISTRY
- L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments
- (2010) Chenere P. Ramsey et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Secrets of the shaking palsy
- (2010) Jim Schnabel NATURE
- The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis
- (2010) W. Michael Panneton et al. PLoS One
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Parkin-induced mitophagy in the pathogenesis of Parkinson disease
- (2009) Derek Narendra et al. Autophagy
- Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6
- (2009) E Giaime et al. CELL DEATH AND DIFFERENTIATION
- Oxidative Status of DJ-1-dependent Activation of Dopamine Synthesis through Interaction of Tyrosine Hydroxylase and 4-Dihydroxy-l-phenylalanine (l-DOPA) Decarboxylase with DJ-1
- (2009) Shizuma Ishikawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation
- (2009) A. Kathrin Lutz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV -Synucleinopathy
- (2009) C. Y. Chung et al. JOURNAL OF NEUROSCIENCE
- Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons
- (2009) Eugene V. Mosharov et al. NEURON
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomic investigation of α-synuclein multiplication and parkinsonism
- (2008) Owen A. Ross et al. ANNALS OF NEUROLOGY
- Retromer
- (2008) Juan S Bonifacino et al. CURRENT OPINION IN CELL BIOLOGY
- Dopamine auto-oxidation aggravates non-apoptotic cell death induced by over-expression of human A53T mutant alpha-synuclein in dopaminergic PC12 cells
- (2008) Zhi Dong Zhou et al. JOURNAL OF NEUROCHEMISTRY
- Mitochondria in the aetiology and pathogenesis of Parkinson's disease
- (2008) Anthony HV Schapira LANCET NEUROLOGY
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- In vivo silencing of alpha-synuclein using naked siRNA
- (2008) Jada Lewis et al. Molecular Neurodegeneration
- Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism
- (2008) Bogdan Brodacki et al. NEUROSCIENCE LETTERS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started