Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S-Parkinson’s disease

The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies

(2017) Claustre Pont-Sunyer et al.   MOVEMENT DISORDERS

Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants

(2017) Irene Lopez-Fabuel et al.   NEUROCHEMISTRY INTERNATIONAL

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Mitochondrial DNA disturbances and deregulated expression of oxidative phosphorylation and mitochondrial fusion proteins in sporadic inclusion body myositis

(2016) M. Catalan-Garcia et al.   CLINICAL SCIENCE

The Role of Therapeutic Drugs on Acquired Mitochondrial Toxicity

(2016) Constanza Morén et al.   CURRENT DRUG METABOLISM

LRRK2 interferes with aggresome formation for autophagic clearance

(2016) Yeojin Bang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Impaired Mitochondrial Function and Dynamics in the Pathogenesis of FXTAS

(2016) M. I. Alvarez-Mora et al.   MOLECULAR NEUROBIOLOGY

Comparative blood transcriptome analysis in idiopathic and LRRK2 G2019S–associated Parkinson's disease

(2016) Jon Infante et al.   NEUROBIOLOGY OF AGING

Mitochondrial disturbances in HIV pregnancies

(2015) Constanza Morén et al.   AIDS

LRRK2 Pathways Leading to Neurodegeneration

(2015) Mark R. Cookson   Current Neurology and Neuroscience Reports

Cellular processes associated with LRRK2 function and dysfunction

(2015) Rebecca Wallings et al.   FEBS Journal

Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase Inhibition

(2015) G. A. Smith et al.   MOLECULAR NEUROBIOLOGY

UDCA exerts beneficial effect on mitochondrial dysfunction inLRRK2G2019Scarriers and in vivo

(2015) Heather Mortiboys et al.   NEUROLOGY

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Mitocentric View of Parkinson's Disease

(2014) Nele A. Haelterman et al.   Annual Review of Neuroscience

Defining and measuring autophagosome flux—concept and reality

(2014) Ben Loos et al.   Autophagy

LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis

(2014) A. Raquel Esteves et al.   EXPERIMENTAL NEUROLOGY

The Upshot of LRRK2 Inhibition to Parkinson’s Disease Paradigm

(2014) A. R. Esteves et al.   MOLECULAR NEUROBIOLOGY

Does Uncoupling Protein 2 Expression Qualify as Marker of Disease Status in LRRK2-Associated Parkinson's Disease?

(2013) Anne Grünewald et al.   ANTIOXIDANTS & REDOX SIGNALING

Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

(2013) Claudia Manzoni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Study of oxidative, enzymatic mitochondrial respiratory chain function and apoptosis in perinatally HIV-infected pediatric patients

(2013) Constanza Morén et al.   DRUG AND CHEMICAL TOXICOLOGY

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

(2013) Yu-Chin Su et al.   HUMAN MOLECULAR GENETICS

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

LRRK2 Affects Vesicle Trafficking, Neurotransmitter Extracellular Level and Membrane Receptor Localization

(2013) Rossana Migheli et al.   PLoS One

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

(2012) José M. Bravo-San Pedro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

Cellular models to investigate biochemical pathways in Parkinson’s disease

(2012) Tiziana Alberio et al.   FEBS Journal

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

(2012) Tatiana D. Papkovskaia et al.   HUMAN MOLECULAR GENETICS

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers

(2011) Kathrin Brockmann et al.   MOVEMENT DISORDERS

Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers

(2011) C. Marras et al.   NEUROLOGY

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

Galactose Enhances Oxidative Metabolism and Reveals Mitochondrial Dysfunction in Human Primary Muscle Cells

(2011) Céline Aguer et al.   PLoS One

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

A comparative study of Lrrk2 function in primary neuronal cultures

(2010) Justus C. Dächsel et al.   PARKINSONISM & RELATED DISORDERS

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Abnormal mitochondrial dynamics and neurodegenerative diseases

(2009) Bo Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genetic and Functional Mitochondrial Assessment of HIV-Infected Patients Developing HAART-Related Hyperlactatemia

(2009) Glòria Garrabou et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts

(2008) Heather Mortiboys et al.   ANNALS OF NEUROLOGY

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

(2008) Anthony K.F. Liou et al.   NEUROBIOLOGY OF DISEASE

A clinical, neuropsychological and olfactory evaluation of a large family with LRRK2 mutations

(2008) Ebba Lohmann et al.   PARKINSONISM & RELATED DISORDERS