Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

Selective turnover of p62/A170/SQSTM1 by autophagy

(2014) Yoshinobu Ichimura et al.   Autophagy

Autophagy in the Central Nervous System: Implications for Neurodegenerative Disorders

(2012) Maria Xilouri et al.   CNS & Neurological Disorders-Drug Targets

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

(2011) Valerie Cullen et al.   ANNALS OF NEUROLOGY

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Autophagic pathways in Parkinson disease and related disorders

(2011) Maria Xilouri et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

(2011) Vinay Choubey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Matrix Metalloproteinase 3-mediated α-Synuclein Cleavage in Dopaminergic Cell Death

(2011) Dong-Hee Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Interacts with Glucocerebrosidase Providing a Molecular Link between Parkinson and Gaucher Diseases

(2011) Thai Leong Yap et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

(2011) Timothy J. Collier et al.   NATURE REVIEWS NEUROSCIENCE

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Ubiquitin ligase Nedd4 promotes  -synuclein degradation by the endosomal-lysosomal pathway

(2011) G. K. Tofaris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein fate is determined by USP9X-regulated monoubiquitination

(2011) R. Rott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNS expression of glucocerebrosidase corrects  -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

(2011) S. P. Sardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1 Cleavage by Matrix Metalloproteinase 3 Mediates Oxidative Stress-Induced Dopaminergic Cell Death

(2010) Dong-Hee Choi et al.   ANTIOXIDANTS & REDOX SIGNALING

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

Overview of macroautophagy regulation in mammalian cells

(2010) Maryam Mehrpour et al.   CELL RESEARCH

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

(2010) Youhei Machiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Protein degradation, aggregation, and misfolding

(2010) Ana Maria Cuervo et al.   MOVEMENT DISORDERS

Extracellular neurosin degrades α-synuclein in cultured cells

(2010) Harutsugu Tatebe et al.   NEUROSCIENCE RESEARCH

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

The 26S proteasome: assembly and function of a destructive machine

(2010) Nerea Gallastegui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein

(2009) Wai Haung Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism

(2009) Amy B. Manning-Boğ et al.   NEUROTOXICOLOGY

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy

(2009) Q. Yang et al.   SCIENCE

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

(2009) Valerie Cullen et al.   Molecular Brain

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Increased α-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

(2008) Johannes Levin et al.   EXPERIMENTAL NEUROLOGY

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells

(2008) Dong Hee Choi et al.   JOURNAL OF NEUROCHEMISTRY

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome

(2008) Evangelia Emmanouilidou et al.   NEUROBIOLOGY OF AGING

Cleavage of normal and pathological forms of α-synuclein by neurosin in vitro

(2008) Takashi Kasai et al.   NEUROSCIENCE LETTERS

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain