Article
Endocrinology & Metabolism
Chao Cao, Han-Chow E. Koh, Stephan Van Vliet, Bruce W. Patterson, Dominic N. Reeds, Richard Laforest, Robert J. Gropler, Bettina Mittendorfer
Summary: This study found that enhanced FFA clearance in people with obesity is negatively correlated with muscle insulin sensitivity, and the stimulatory effect of insulin on FFA clearance is more significant in obese individuals.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Bluher, Andre Kleinridders
Summary: The intake of high-fat diets leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium can protect against the development of diet-induced insulin resistance. However, selenium might not be able to attenuate insulin resistance in the presence of obesity.
Article
Biochemistry & Molecular Biology
Viswanathan Saraswathi, Narendra Kumar, Weilun Ai, Thiyagarajan Gopal, Saumya Bhatt, Edward N. Harris, Geoffrey A. Talmon, Cyrus Desouza
Summary: The intake of myristic acid (MA) exacerbates obesity-associated insulin resistance, partially mediated by increased adipose tissue inflammation and secretion of resistin.
Article
Biochemistry & Molecular Biology
Daniel Castellano-Castillo, Bruno Ramos-Molina, Wilfredo Oliva-Olivera, Luis Ocana-Wilhelmi, Maria Isabel Queipo-Ortuno, Fernando Cardona
Summary: This study aimed to analyze the changes in H3K4me3 histone mark in human adipose tissue under obesity and insulin resistance conditions. The results showed that H3K4me3 enrichment in gene promoters was closely related to higher mRNA levels, and differentially enriched H3K4me3 could regulate genes in adipose tissue, affecting its function during obesity and insulin resistance.
Article
Nutrition & Dietetics
Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu
Summary: The study suggests that PCSK9 expression in adipose tissue may mediate statin-induced adipocyte insulin resistance. PCSK9 deficiency could protect against statin-induced impairments in insulin signaling.
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Andre C. Carpentier
Summary: Insulin plays a significant role in regulating adipose tissue fatty acid metabolism by inhibiting NEFA flux. Insulin resistance in adipose tissue may lead to various metabolic abnormalities and complications of diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Review
Cell Biology
Zhaohua Cai, Yijie Huang, Ben He
Summary: Obesity is a global epidemic associated with chronic low-grade inflammation. Macrophages play a crucial role in obesity-associated inflammation. Recent research has provided insights into the diverse roles of adipose tissue macrophages (ATMs) in obesity and comorbidities. This review summarizes the characterization of different subpopulations of ATMs in obesity, the extensive crosstalk between adipocytes and ATMs, and the extended crosstalk within adipose tissue between perivascular mesenchymal cells and ATMs.
Article
Medicine, Research & Experimental
Benedikt Dietz, Juergen Machann, Vaibhav Agrawal, Martin Heni, Patrick Schwab, Julia Dienes, Steffen Reichert, Andreas L. Birkenfeld, Hans-Ulrich Haering, Fritz Schick, Norbert Stefan, Andreas Fritsche, Hubert Preissl, Bernhard Schoelkopf, Stefan Bauer, Robert Wagner
Summary: The study indicated that diabetes can be detected through whole-body MRI without additional data, with visceral fat playing a crucial role in diabetes classification. The model identified a high-risk group with increased risk for future diabetes and microalbuminuria.
Review
Endocrinology & Metabolism
Xi-Ding Yang, Xing-Cheng Ge, Si-Yi Jiang, Yong-Yu Yang
Summary: Epidemic obesity is a significant public health problem associated with an increase in obesity-related metabolic diseases. Adipose tissue plays a vital role in regulating whole-body energy metabolism, and lipolysis, the degradation of triglycerides in adipocytes, is closely linked to obesity and its metabolic disorders. Natural products, including flavonoids, alkaloids, and terpenoids, can regulate lipolysis and potentially contribute to weight loss and improved metabolic conditions associated with obesity. Identifying specific secondary metabolites that are effective in reducing weight and mitigating the health risks associated with obesity and lipolysis regulation is crucial.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
M. Carmen Navarro-Ruiz, M. Carmen Soler-Vazquez, Alberto Diaz-Ruiz, Juan R. Peinado, Andrea Nieto Calonge, Julia Sanchez-Ceinos, Carmen Tercero-Alcazar, Jaime Lopez-Alcala, Oriol A. Rangel-Zuniga, Antonio Membrives, Jose Lopez-Miranda, Maria M. Malagon, Rocio Guzman-Ruiz
Summary: This study investigated the carbonylome of subcutaneous and omental human adipose tissue in obesity-associated insulin resistance. The results showed differences in carbonylated proteins between different fat depots, highlighting the complexity of oxidative stress at the metabolic level. Furthermore, the study revealed the altered expression and function of carbonylated transferrin, linking oxidative stress to metabolic dysfunction. This research provides insights into the molecular mechanisms underlying adipocyte dysfunction in obesity and identifies potential targets for therapeutic intervention.
Article
Biochemistry & Molecular Biology
Tehila Daniel, Michaella Ben-Shachar, Elyashiv Drori, Sharleen Hamad, Anna Permyakova, Elad Ben-Cnaan, Joseph Tam, Zohar Kerem, Tovit Rosenzweig
Summary: Grape pomace has the potential to improve insulin sensitivity and reduce fat deposition in the liver, which may have beneficial health outcomes for the prevention and treatment of hepatic steatosis and other obesity-related pathologies.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Xiaohui Li, Jia Liu, Biao Zhou, Yinhui Li, Zhengyu Wu, Hua Meng, Guang Wang
Summary: Adipose tissue insulin resistance (adipose-IR) in males is higher than in females with similar BMI levels. Adipose-IR increases progressively from overweight to class III obesity in both genders, but is significantly higher in males than females in the class III obesity group. Testosterone levels are negatively correlated with adipose-IR in males, while positively correlated in females. Low testosterone levels may contribute to more severe adipose-IR in obese males.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Allah Nawaz, Yasuhiro Nishida, Akiko Takikawa, Shiho Fujisaka, Tomonobu Kado, Aminuddin Aminuddin, Muhammad Bilal, Ishtiaq Jeelani, Muhammad Rahil Aslam, Ayumi Nishimura, Takahide Kuwano, Yoshiyuki Watanabe, Yoshiko Igarashi, Keisuke Okabe, Saeed Ahmed, Azhar Manzoor, Isao Usui, Kunimasa Yagi, Takashi Nakagawa, Kazuyuki Tobe
Summary: Astaxanthin has beneficial effects on adipose tissue in obese mice, reducing oxidative stress and macrophage infiltration, maintaining healthy AT function, and preventing pathological remodeling of AT.
Review
Endocrinology & Metabolism
Rana Halloun, Ram Weiss
Summary: Severe obesity among adolescents is a growing concern, and conservative treatments have limited effects. Bariatric surgery has shown promising short-term outcomes in weight loss and resolution of metabolic complications, but long-term follow-up reveals weight regain and potential side effects. Pharmaceutical interventions, such as GLP-1 analogues, offer alternative options for moderate weight loss and metabolic improvement in obese adolescents. Proper selection and follow-up are crucial for the success of bariatric surgery in severe cases.
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Daniella Magen, Rana Halloun, Alfonso Galderisi, Sonia Caprio, Ram Weiss
Summary: This study found that childhood obesity is associated with renal morbidity, and insulin sensitivity affects eGFR. Male sex had higher eGFR values than females, and insulin sensitivity decreased with eGFR. Adjusted eGFR was positively associated with systolic blood pressure and negatively associated with microalbuminuria.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Surgery
Tair Ben-Porat, Shiraz Peretz, Amihai Rottenstreich, Ram Weiss, Auryan Szalat, Ram Elazary, Mahmud Abu Gazala
Summary: This study evaluated the changes in bone mineral density (BMD) in women who underwent sleeve gastrectomy (SG) for 2 years postoperatively. The results showed that despite significant weight loss, patients experienced significant bone loss at the total hip and femoral neck. Future studies should investigate interventions to attenuate skeletal deterioration after SG.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Endocrinology & Metabolism
Resthie R. Putri, Thomas Casswall, Emilia Hagman
Summary: The severity of obesity, metabolic risk parameters, and outcomes of obesity treatment impact the risk of Non-Alcoholic Fatty Liver Disease (NAFLD) in pediatric obesity. Factors such as severe obesity, impaired fasting glucose, and high triglycerides increase the risk for NAFLD, while successful obesity treatment reduces this risk significantly.
Article
Endocrinology & Metabolism
Rana Halloun, Alfonso Galderisi, Sonia Caprio, Ram Weiss
Summary: In children and adolescents with obesity, exposure to hyperinsulinemia, greater insulin secretion, or low postprandial glucose is not associated with greater increases in the degree of obesity over 2-4 years.
Article
Endocrinology & Metabolism
Nehama Zuckerman Levin, Meidan Cohen, Moshe Phillip, Ariel Tenenbaum, Ilana Koren, Yardena Tenenbaum-Rakover, Osnat Admoni, Eli Hershkovitz, Alon Haim, Kineret Mazor Aronovitch, David Zangen, David Strich, Avivit Brener, Yonatan Yeshayahu, Yossi Schon, Marianna Rachmiel, Tal Ben-Ari, Floris Levy-Khademi, Rami Tibi, Ram Weiss, Yael Lebenthal, Orit Pinhas-Hamiel, Naim Shehadeh
Summary: The incidence of youth-onset type 2 diabetes in Israel has significantly increased, with patients mainly being female and Jewish, exhibiting characteristics such as high BMI, hypertension, abnormal blood sugar levels, metabolic syndrome, and fatty liver.
PEDIATRIC DIABETES
(2022)
Article
Pediatrics
Moria Be'er, Shai Bushmitz, Michal Cahal, Efraim Sadot, Sivan Yochpaz, Omri Besor, Israel Amirav, Moran Lavie
Summary: This case-control study aimed to evaluate the association between hospitalization in the PICU due to RSV bronchiolitis and future asthma in early life. The results showed that children admitted to the PICU for RSV bronchiolitis are at higher risk for asthma in subsequent pre-school years and will require close respiratory follow-up.
PEDIATRIC PULMONOLOGY
(2022)
Article
Medicine, General & Internal
Inbal Akavian, Itay Nitzan, Tomer Talmy, Maya Nitecki, Sami Gendler, Omri Besor
Summary: Little is known about the symptoms, their duration, and occupational implications of COVID-19 in the military population. This study aimed to describe the clinical presentation and estimate the loss of workdays due to mild COVID-19 during an Omicron predominant wave among a young, healthy, and mostly vaccinated military population. The findings show that even among a young and fully vaccinated population, COVID-19 caused by the Omicron variant may result in substantial medical leave from military service.
Article
Endocrinology & Metabolism
Rana Halloun, Alfonso Galderisi, Sonia Caprio, Ram Weiss
Summary: This study found that adipose tissue insulin resistance does not protect against increases in the degree of obesity in youth with obesity, and skeletal muscle insulin resistance is not associated with increases in the degree of obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Nicole Prinz, Resthie R. R. Putri, Thomas Reinehr, Pernilla Danielsson, Daniel Weghuber, Mikael Norman, Niels Rochow, Claude Marcus, Reinhard W. Holl, Emilia Hagman
Summary: Background: Children with obesity have an increased risk of cardiometabolic risk factors, but not all children carry a similar risk. Perinatal factors, i.e., gestational age (GA) and birth weight for GA, may affect the risk for metabolic complications. However, there are conflicting data whether the association between birth size and cardiometabolic risk factors is independent among children with obesity. Moreover, differential effects of GA and birth weight for GA on cardiometabolic risk factors in pediatric obesity are still unexplored. We aimed to investigate the association between birth weight for GA and cardiometabolic risk factors in children and adolescents with overweight or obesity and to assess whether the association is modified by prematurity.
Article
Pediatrics
Michal Cahal, Israel Amirav, Mika Rochman, Moria Be'er, Omri Besor, Moran Lavie
Summary: This study examined the effects of repeated lockdowns on children with respiratory disorders. The results showed that while respiratory symptoms and exacerbation frequency were reduced, the third lockdown was associated with greater use of reliever medications, less use of inhaled corticosteroids as routine treatment, and more pediatric emergency room visits and hospitalizations compared to the first lockdown. The study also found an increase in sedentary lifestyle and reduced adherence to lockdown policies.
Article
Endocrinology & Metabolism
Resthie R. Putri, Pernilla Danielsson, Claude Marcus, Emilia Hagman
Summary: This study aimed to investigate the effect of obesity severity and treatment outcome on growth. It was found that obesity severity is positively associated with height and growth velocity, and successful obesity treatment can normalize the growth velocity pattern. Therefore, a hampered growth spurt should be anticipated during puberty, especially in adolescents with severe obesity, and there is no difference in final height between different levels of obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Endocrinology & Metabolism
Ram Weiss
JOURNAL OF DIABETES
(2023)
Article
Orthopedics
Omri Besor, Mark Eidelman, Pavel Kotlarsky
Summary: This study reports the experience of simultaneous ankle arthrodesis and tibial lengthening using external fixation in adolescent and young adult patients. The surgeries included correction of ankle deformity and resection of the distal tibial joint surface and the talar dome. The results showed that this combined procedure provides a stable ankle and restores tibia length even in complex and challenging situations.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Shivang Parikh, Roma Parikh, Keren Michael, Lior Bikovski, Georgina Barnabas, Mariya Mardamshina, Rina Hemi, Paulee Manich, Nir Goldstein, Hagar Malcov-Brog, Tom Ben-Dov, Ohad Glaich, Daphna Liber, Yael Bornstein, Koral Goltseker, Roy Ben-Bezalel, Mor Pavlovsky, Tamar Golan, Liron Spitzer, Hagit Matz, Pinchas Gonen, Ruth Percik, Lior Leibou, Tomer Perluk, Gil Ast, Jacob Frand, Ronen Brenner, Tamar Ziv, Mehdi Khaled, Shamgar Ben-Eliyahu, Segev Barak, Orit Karnieli-Miller, Eran Levin, Yftach Gepner, Ram Weiss, Paul Pfluger, Aron Weller, Carmit Levy
Summary: Ultraviolet exposure on the skin increases food intake and body weight in males, but not in females. This sexual dimorphism is mediated by the expression of ghrelin in skin adipocytes. These findings highlight the significant metabolic differences between males and females and the important role of the skin in energy homeostasis. Furthermore, this research may lead to potential sex-based treatments for endocrine-related diseases.