The NLRP3 Inflammasome in Alzheimer’s Disease

Innate Immunity in Alzheimer’s Disease: A Complex Affair

(2013) Marie-Victoire Guillot-Sestier et al.   CNS & Neurological Disorders-Drug Targets

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

(2012) Fushan Shi et al.   Journal of Neuroinflammation

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

(2012) N Riteau et al.   Cell Death & Disease

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Deregulated inflammasome signaling in disease

(2011) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens

(2011) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation

(2011) Fabrizio Gardoni et al.   Journal of Neuroinflammation

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Inflammasome Inhibition as a Pathogenic Stealth Mechanism

(2010) Debra J. Taxman et al.   Cell Host & Microbe

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Targeting IL-1β in disease; the expanding role of NLRP3 inflammasome

(2010) Ioannis Mitroulis et al.   European Journal of Internal Medicine

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Neuroimmunomodulation in the Pathogenesis of Alzheimer’s Disease

(2010) Inelia Morales et al.   NEUROIMMUNOMODULATION

The Role of Neuroimmunomodulation in Alzheimer's Disease

(2009) Ricardo B. Maccioni et al.   Annals of the New York Academy of Sciences

Evolution and functional divergence of NLRP genes in mammalian reproductive systems

(2009) Xin Tian et al.   BMC EVOLUTIONARY BIOLOGY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

(2009) Greta Guarda et al.   NATURE

Mechanisms of regulated unconventional protein secretion

(2009) Walter Nickel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Inflammasomes

(2009) Mohamed Lamkanfi et al.   PLoS Pathogens

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

(2007) Johanna Ojala et al.   NEUROBIOLOGY OF AGING