Intracellular sensing of viral genomes and viral evasion

Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production

(2019) Arundhati Ghosh et al.   IMMUNITY

The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance IFN-β response

(2019) Susana Soo-Yeon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

(2019) Jiang Dai et al.   CELL

Double-Stranded RNA Sensors and Modulators in Innate Immunity

(2019) Sun Hur   Annual Review of Immunology

RIG-I and Other RNA Sensors in Antiviral Immunity

(2018) Kwan T. Chow et al.   Annual Review of Immunology

Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

(2018) Yuhei Maruzuru et al.   Cell Host & Microbe

Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion

(2018) Zhe-Fu Huang et al.   Cell Host & Microbe

RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling

(2018) Jean‐Patrick Parisien et al.   EMBO REPORTS

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling

(2018) Rocío Núñez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA

(2018) Puxian Fang et al.   JOURNAL OF VIROLOGY

Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling

(2018) Maria T. Sánchez-Aparicio et al.   JOURNAL OF VIROLOGY

RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses

(2018) Zhao-Shan Liu et al.   Cell and Bioscience

RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes

(2018) Maxime Chazal et al.   Cell Reports

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome

(2018) Soham Gupta et al.   PLoS Pathogens

Latent Membrane Protein 1 of Epstein–Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway

(2018) Chongfeng Xu et al.   Frontiers in Immunology

Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

(2018) Junjie Zhang et al.   Cell Host & Microbe

Positive regulatory role of c-Src-mediated TRIM25 tyrosine phosphorylation on RIG-I ubiquitination and RIG-I-mediated antiviral signaling pathway

(2018) Na-Rae Lee et al.   CELLULAR IMMUNOLOGY

Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1‐caspase‐1 axis

(2018) Yanyan Zheng et al.   EMBO JOURNAL

The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors

(2018) Huan Lian et al.   IMMUNITY

HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection

(2018) Donna A. MacDuff et al.   JOURNAL OF VIROLOGY

Innate Sensing of DNA Virus Genomes

(2018) Zhe Ma et al.   Annual Review of Virology

Encephalomyocarditis virus 2C protein antagonizes interferon-β signaling pathway through interaction with MDA5

(2018) Liang Li et al.   ANTIVIRAL RESEARCH

USP14 promotes K63-linked RIG-I deubiquitination and suppresses antiviral immune responses

(2018) Hongrui Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

G3BP1 promotes DNA binding and activation of cGAS

(2018) Zhao-Shan Liu et al.   NATURE IMMUNOLOGY

Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling

(2018) Junsu Ban et al.   Viruses-Basel

Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses

(2017) Lei Hei et al.   HEPATOLOGY

Cytosolic nucleic acid sensors and innate immune regulation

(2017) Daisuke Ori et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

RNA sensors of the innate immune system and their detection of pathogens

(2017) Nanhua Chen et al.   IUBMB LIFE

Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

(2017) Ming-Ming Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MCPIP1 attenuates the innate immune response to influenza A virus by suppressing RIG-I expression in lung epithelial cells

(2017) Xiaoning Sun et al.   JOURNAL OF MEDICAL VIROLOGY

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

(2017) Joschka Willemsen et al.   MOLECULAR CELL

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling

(2017) Peng Tan et al.   MOLECULAR CELL

PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2

(2017) Yonghong Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational Control of Intracellular Pathogen Sensing Pathways

(2017) Cindy Chiang et al.   TRENDS IN IMMUNOLOGY

Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome

(2017) Yuan Huang et al.   Virology Journal

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

(2017) K. L. Jønsson et al.   Nature Communications

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection

(2017) Rebecca Mahony et al.   Scientific Reports

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I

(2017) Chunyuan Zhao et al.   Cell Reports

Protect this house: cytosolic sensing of viruses

(2017) Michael J McFadden et al.   Current Opinion in Virology

Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation

(2017) Stephen Soonthornvacharin et al.   Nature Microbiology

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

(2017) Sebastian Aguirre et al.   Nature Microbiology

A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation

(2016) Jun Zhao et al.   Cell Host & Microbe

HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I

(2016) S. J. Choi et al.   EMBO JOURNAL

RNF123 has an E3 ligase‐independent function in RIG‐I‐like receptor‐mediated antiviral signaling

(2016) Shuai Wang et al.   EMBO REPORTS

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

(2016) Xueting Lang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression

(2016) Zixiang Zhu et al.   JOURNAL OF VIROLOGY

Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency

(2016) Arunava Roy et al.   JOURNAL OF VIROLOGY

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

(2016) Meixin Chen et al.   MOLECULAR CELL

A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity

(2016) Ying Kai Chan et al.   NATURE IMMUNOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

(2016) Pengyan Xia et al.   NATURE IMMUNOLOGY

Viral evasion of intracellular DNA and RNA sensing

(2016) Ying Kai Chan et al.   NATURE REVIEWS MICROBIOLOGY

RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation

(2016) Wendie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

(2016) Guigen Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

(2016) Tao Liu et al.   Cell Reports

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

(2016) Megan R. Edwards et al.   Cell Reports

Cytosolic Innate Immune Sensing and Signaling upon Infection

(2016) Lilliana Radoshevich et al.   Frontiers in Microbiology

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

(2016) Helene Minyi Liu et al.   EBioMedicine

Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I

(2015) Kai Zhao et al.   JOURNAL OF IMMUNOLOGY

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

(2015) G. Manokaran et al.   SCIENCE

Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I

(2015) Alexander S. Jureka et al.   STRUCTURE

RIOK3-Mediated Phosphorylation of MDA5 Interferes with Its Assembly and Attenuates the Innate Immune Response

(2015) Ken Takashima et al.   Cell Reports

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

(2015) Gil Ju Seo et al.   Cell Reports

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

(2015) Dipanjan Dutta et al.   PLoS Pathogens

HMGB1–DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE

(2014) Liying Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases

(2014) Annelies W. Mesman et al.   Cell Host & Microbe

Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses

(2014) Qiming Liang et al.   Cell Host & Microbe

Negative Regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent Antiviral Innate Immune Responses by Arf-like Protein 5B

(2014) Yuichi Kitai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation

(2014) Changcheng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

(2014) Yihui Fan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enterovirus 2Apro Targets MDA5 and MAVS in Infected Cells

(2014) Q. Feng et al.   JOURNAL OF VIROLOGY

Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses

(2014) F. W. Santiago et al.   JOURNAL OF VIROLOGY

TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production

(2014) K. Narayan et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

(2014) K.-L. Siu et al.   JOURNAL OF VIROLOGY

Paramyxovirus V Protein Interaction with the Antiviral Sensor LGP2 Disrupts MDA5 Signaling Enhancement but Is Not Relevant to LGP2-Mediated RLR Signaling Inhibition

(2014) Kenny R. Rodriguez et al.   JOURNAL OF VIROLOGY

Innate Nuclear Sensor IFI16 Translocates into the Cytoplasm during the Early Stage of In Vitro Human Cytomegalovirus Infection and Is Entrapped in the Egressing Virions during the Late Stage

(2014) V. Dell'Oste et al.   JOURNAL OF VIROLOGY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

(2014) K. Kuniyoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors

(2014) Dahai Luo   RNA Biology

The Ubiquitin-Specific Protease USP15 Promotes RIG-I-Mediated Antiviral Signaling by Deubiquitylating TRIM25

(2014) E.-K. Pauli et al.   Science Signaling

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

(2014) J. Yan et al.   Journal of Molecular Cell Biology

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion

(2013) Tuo Li et al.   Cell Host & Microbe

USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors

(2013) Jun Cui et al.   CELL RESEARCH

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

The Viral Ubiquitin Ligase ICP0 Is neither Sufficient nor Necessary for Degradation of the Cellular DNA Sensor IFI16 during Herpes Simplex Virus 1 Infection

(2013) D. Cuchet-Lourenco et al.   JOURNAL OF VIROLOGY

USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I

(2013) L. Wang et al.   JOURNAL OF VIROLOGY

Negative Regulation of RIG-I-Mediated Innate Antiviral Signaling by SEC14L1

(2013) M.-T. Li et al.   JOURNAL OF VIROLOGY

Toscana Virus NSs Protein Inhibits the Induction of Type I Interferon by Interacting with RIG-I

(2013) G. Gori-Savellini et al.   JOURNAL OF VIROLOGY

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells

(2013) Cristina Amparo Hagmann et al.   PLoS One

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

(2013) Hiroyuki Oshiumi et al.   PLoS Pathogens

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

(2012) Helene Minyi Liu et al.   Cell Host & Microbe

Structural insights into RNA recognition and activation of RIG-I-like receptors

(2012) Daisy W Leung et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Human Respiratory Syncytial Virus Nucleoprotein and Inclusion Bodies Antagonize the Innate Immune Response Mediated by MDA5 and MAVS

(2012) A. W. Lifland et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5

(2012) J. Xing et al.   JOURNAL OF VIROLOGY

Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16

(2012) T. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein

(2011) Akhil Rajput et al.   IMMUNITY

Conventional Protein Kinase C-  (PKC- ) and PKC-  Negatively Regulate RIG-I Antiviral Signal Transduction

(2011) N. P. Maharaj et al.   JOURNAL OF VIROLOGY

The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase

(2011) D. Wang et al.   JOURNAL OF VIROLOGY

DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

(2011) M. Miyashita et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential Roles for the Interferon-Inducible IFI16 and AIM2 Innate Immune Sensors for Cytosolic DNA in Cellular Senescence of Human Fibroblasts

(2011) X. Duan et al.   MOLECULAR CANCER RESEARCH

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through Its Interaction with the Cellular IFI16 Protein

(2010) I. M. Cristea et al.   JOURNAL OF VIROLOGY

Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

MDA5 is SUMOylated by PIAS2β in the upregulation of Type I interferon signaling

(2010) Jihuan Fu et al.   MOLECULAR IMMUNOLOGY

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I

(2010) Penghua Wang et al.   NATURE IMMUNOLOGY

ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

(2010) Sumio Hayakawa et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2

(2009) J.-P. Parisien et al.   JOURNAL OF VIROLOGY

RIG-I is cleaved during picornavirus infection

(2009) Paola M. Barral et al.   VIROLOGY

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

(2008) Kiyohiro Takahasi et al.   MOLECULAR CELL

UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I

(2007) Kei-Ichiro Arimoto et al.   MOLECULAR IMMUNOLOGY